Synthesis, characterization and anticancer evaluation of novel tri-arm star shaped 1,3,5-triazine hydrazones

Triazine as a promising scaffold for its versatile biological behavior

“…9). Symmetrical trisubstituted trishaped triazine hydrazones [48] have been evaluated for their in vitro anticancer activity against the human liver carcinoma cell line HepG2 and human cervix carcinoma cell line HeLa and also acted as cytotoxic agents with the ability to prevent cell progression in cancerous cells [49]. Compounds 23a and 23b bearing p-fluoro and p-chloro substituents, exhibited a broad spectrum of antitumor activity against HepG2cells with percent inhibition of 4.32% and 6.41% respectively, while in case of HeLa cell line compounds 23c and 23d bearing p-nitro and p-methoxy substituents showed percent inhibition of 8.36% and 9.37% respectively.…”

Synthesis, Characterization and Anti-Inflammatory Activity of Hydrazones Bearing 5-Nitro-Furan Moiety and 5-Iodo-Vanillin Hybrid

“…[5,6] Hydrazide-hydrazones represent a class of organic compounds embedded with azomethine group (-NH-N=CH-) linked with carbonyl group that have occupied a prominent place in the branch of medicinal chemistry and exhibits various pharmaceutical applications [7] Some of the examples of chemotherapeutic agents that are known to contain hydrazide-hydrazone moiety are nitrofurazone, [8] furazolidone [9,10] and nitrofurantoin. [11,12] In addition to the above example, a lot of biologically important hydrazide-hydrazone derivatives were found to possess antiprotozoal, [13] anticonvulsant, [14] anticancer, [15][16][17][18] antiviral [19] and antiinflammatory [20] activities.…”

Structural and spectroscopic characterization oF N’-[(1E)-(4-fluorophenyl)methylidene]thiophene-2-carbohydrazide, a potential precursor to bioactive agents

“…As a result of an extensive search based on homocyclic and heterocyclic hydrazides and hydrazones, several derivatives were developed and proved to be superior to INH [2][3][4][5][6][7][8]. In addition, several hydrazide and hydrazine derivatives were reported to possess marked antifungal [9][10][11][12], antileishmanial [13,14], antiviral [15], anticancer [16][17][18], anti-inflammatory [19] and antioxidant [20] activities. Moreover, carbohydrazide-hydrazones are utilized as efficient intermediates for the synthesis of several biologically-active heterocyclic compounds.…”