Synthesis, characterization and antifungal studies of metalloquinolone [Cd₂(nal)₂(phen)₂(Cl)₂]

Abstract

A novel dinuclear, distorted octahedral complex of nalidixic acid (nal) with Cd(II) metal ion with the formula [Cd 2 (Nal) 2 (Phen) 2 (Cl) 2 ] has been synthesized in the presence of N-containing heterocyclic ligand, 1,10-phenanthroline (phen). The synthesized metal complex was characterized using CHN analysis, Fourier transformed infra-red, thermo gravimetric analysis, differential scanning chalorimetry, nuclear magnetic resonance, ultra violet-visible and single-crystal X-ray diffraction. The newly synthesized complex shows more pronounced antifungal activity compared with the parent quinolone against four fungi, namely Pythium aphanidermatum, Sclerotinia rolfsii, Rhizoctonia solani and Rhizoctonia bataticola.

N2O2‐chelate metal complexes with Schiff base ligand: Synthesis, characterisation and contribution as a promising antiviral agent against human cytomegalovirus

“…[ 34–39 ] The shift of the ν(C=N) group in the spectra of metal complexes to a lower values in a range of 1500–1572 cm −1 implied that the C=N coordinated with the metal ion via nitrogen atom. [ 40,41 ] The existence of such a band at 1711 cm −1 and the existence of asymmetrical stretching vibration (ν as ) in a region of 1626–1631 cm −1 along with the symmetrical stretching vibration (ν s ) bands of a carboxyl group in a region 1340–1399 cm −1 with ∆ν > 200 cm −1 of the ligated carboxylate group indicated that the carboxyl group reacted as a mono‐dentate via one of oxygen atoms (Scheme 2). [ 42–44 ] Complex ( 3 ) spectrum showed two bands values at 1380 and 791 cm −1 attributed to the existence of NO 3 − group as counter ions [ 40 ] and for complex ( 6 ) the vibrational motion v (Zr = O) value existed at 806 cm −1.…”

Synthesis, Characterization, and Antifungal Studies of Cr(III) Complex of Norfloxacin and Bipiridyl Ligand

“…FT-IR spectra of free ligand in KBr disk show that the peak at 1617 cm −1 , assigned for pyridine stretch ν (C=O)py , was slightly shifted to the 1630 cm −1 in the complex (Supplementary Figure S1 in Supplementary Materials available online at http://dx.doi.org/10.1155/2014/457478). In case of free ligand, a characteristic absorption band at ~1733 cm −1 which is assigned for carboxylic stretch ν (C=O)carb , was replaced in the complex by two characteristic bands at 1587 cm −1 and at 1381 cm −1 , assigned as asymmetric ν (O–C–O)a and symmetric ν (O–C–O)s stretching vibrations, respectively [6]. This indicates the involvement of the pyridone oxygen and carboxylate oxygen in the coordination with Cr(III) ion.…”

“…It has been observed that metal complexes with appropriate ligands are biologically more significant and specific than the metal ions and the ligand itself [6–8]. Utilization of metal ions in treatment of various diseases has been thoroughly studied and a large number of quinolone metal complexes with diverse metal ions have been reported [9].…”

Newly synthesised Schiff base metal complexes, characterisation, and contribution as enhancers of colon cancer cell apoptosis by overexpression of P53 protein

“…48 Owing to π-π* and n-π* transitions, groups of ultraviolet spectra to H 2 Enro-o-phdn and its chelates, respectively, are found to range from 269 to 336 nm (Figure S2). 31,49 The shift of π-π* and n-π* transition in the spectra of the complexes demonstrating that the chelation of H 2 Enro-o-phdn to metal ions. 36,50 The new bands in the range 457-489 nm in the chelates' electronic absorption spectra were recognizable to ligand's metal charge transfer ability.…”