SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF RUTHENIUM(III) (E)-2-((6-METHYLBENZO[d]THIAZOL-2-YLIMINO)METHYL)PHENOLCOMPLEXES

doi:10.7324/rjc.2017.1041922

Cited by 3 publications

(4 citation statements)

References 6 publications

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“…The standard agar diffusion method was used to evaluate the cytotoxic activity of the thiosemicarbazone ligand and the complexes against bacteria. 2 The data were collected as triplicate runs. IR Spectra IR spectroscopy is an important analytical technique in order to determine the coordination mode of the metal atom.…”

Section: Antibacterial Activitymentioning

confidence: 99%

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SYNTHESIS, CHARACTERIZATION AND CYTOTOXIC ANTIBACTERIAL ACTIVITY OF Ru(II) ETHOXYSALAL THIOSEMICARBAZONE COMPLEXES

Sampath¹,

Ashokkumar²,

Venkatachalam³

et al. 2019

RJC

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A set of complexes, [RuCl(CO)(B)(EPh3)L] (where E=P/As; B=PPh3/AsPh3/py; L = ligand), of ruthenium have been synthesized by solution method. The structure of the ruthenium(II) complexes were determined by microanalytical techniques and spectral techniques (CHNS, Infrared, ultraviolet-visible and NMR spectroscopic techniques). FT-IR results reveal that thiosemicarbazone is coordinated to Ru(II)via ONS. In addition, the structure of the compounds, thiosemicarbazone ligand and complexes, was confirmed by Nuclear Magnetic Resonance Spectroscopy. Further, the synthesized ligand and its complexes were analyzed against human pathogens.

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Section: Antibacterial Activitymentioning

confidence: 99%

“…Moreover, the ability to resemble the binding properties towards biological significance. 2 Schiff bases bearing N, O and S donor atoms are a kind of versatile ligands in coordination chemistry. Thiosemicarbazones are a class of ligands have emerged as relatively non-innocent ligands with varied biological properties.…”

Section: Introductionmentioning

confidence: 99%

SYNTHESIS, CHARACTERIZATION AND CYTOTOXIC ANTIBACTERIAL ACTIVITY OF Ru(II) ETHOXYSALAL THIOSEMICARBAZONE COMPLEXES

Sampath¹,

Ashokkumar²,

Venkatachalam³

et al. 2019

RJC

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“…[8][9][10][11][12][13][14] Ruthenium complexes having phenanthroline/bipyridyl along with other co-ligands such as hydride, halides and CO have been studied extensively. [15][16][17] Ruthenium phen and/or bpy complexes have been extensively investigated because of their interesting biological properties. The success of cisplatin and related platinum complexes as anticancer agents has created interest of search for more effective and curative transition metal complexes and ruthenium, in particular, has attracted the researchers due to its less toxicity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Dna Binding, Anticancer and Cytotoxic Evaluation of Novel Ruthenium(ii) Isatin Based Schiff Base Complex

Puthilibai¹,

Vasudhevan²

2019

RJC

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Cancer is a leading cause of death worldwide, currently the cancer treatments are radiation therapy, surgery or chemotherapy with the well-known side effects. So far there is no curative therapy available for most of disseminated cancer and thereby the development and discovery of novel therapeutic agents are largely needed. From the development of cisplatin, many scientific groups are actively worked/working for the inorganic anticancer drugs. and have developed a number of Ru(II) complexes with lower systemic toxicity. Ruthenium complexes can penetrate effectively with the tumor cells and bind with DNA. In view of this, we have synthesized novel Ru(II) isatin complex cis-[Ru II (Phen)2 FPIMI] ClO4.2H2O from the reactions between cis-[Ru (Phen)2 Cl2].2H2O and 4fluoro phenyl imino methyl isatin(FPIMI). The new complex was analyzed by elemental analysis and spectral (UV-Vis, FTIR, and 1 H NMR) studies. Further, the complex was subjected to DNA intercalation studies, in vitro anticancer studies and cytotoxic activities. DNA intercalative assay was followed by UV-Vis spectral titration studies with relatively high DNA binding constant, Kb=4.1±2 10 5 M -1 at room temperature. The above studies showed intercalative mode of cleavage with Calf thymus(CT) DNA. The newly synthesized ruthenium(II) complex exhibited more effective in vitro cytotoxic activity against selected cell lines with IC50 value 26±0.5 µM. Also, the anticancer activity of the compound is apparently four times more potent than one of the presently used clinical drug Cisplatin against human tumor cell lines with less cytotoxicity.

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“…The heterometallic system containing multinuclear transition metal complexes leading to the formation of supra-molecular material needs to be explored. These systems are found to be well suited for medical applications which are developed on the properties like good exchange ligand rate, different accessible oxidation states and its capability to mimic iron in binding to biological molecules 1,2 .The Ruthenium complexes due to their extreme stability and catalytic behavior have enunciated an interest in converting the molecule into material leading to several applications 1 .These are also found to exhibit photochromism-a photochemical phenomena 3 . Investigation with ferrocene and its derivatives has led their application as color pigments and also as a high burning rate catalyst 4,5 .Its application as a chemotherapeutic drug has found to have less lethal dosage (LD50)compared to others, which are in vogue 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Heterotrimetallic Ferrocenethiosemicarbozoneru(iii) Complexes With Asph3 for Application as an Chemotherapeutic Drug

R¹,

Aranganayagam²,

Samson³

et al. 2019

RJC

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Developing a heterometallic system enclosing three different spin carriers has enunciated a wider interest in research as it possesses characteristic features for being photo magnets and with combined features like magnetoluminescence and magneto-chirality. These results in greater prospects in developing molecular "prototypes" for quantum computing and drug delivery. This study aims to synthesize the Heterotrimetallic complexes [RuCl(AsPh3)(L)2](where L=bidentate Schiff base ligand of Ferrocenyl thiosemicarbazone and Ferrocenyl-Nphenylthiosemicarbazone) and characterize them using physicochemical analysis and spectroscopic techniques. The results confirm that in the synthesized complexes, ligands are coordinated with Ruthenium atom via NS. Also, the biological studies ascertain its activity towards biomolecules as a potential antibacterial material and could also find its use as a precursor for some chemotherapeutic drugs and also in supramolecular material research.

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SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF RUTHENIUM(III) (E)-2-((6-METHYLBENZO[d]THIAZOL-2-YLIMINO)METHYL)PHENOLCOMPLEXES

Cited by 3 publications

References 6 publications

SYNTHESIS, CHARACTERIZATION AND CYTOTOXIC ANTIBACTERIAL ACTIVITY OF Ru(II) ETHOXYSALAL THIOSEMICARBAZONE COMPLEXES

SYNTHESIS, CHARACTERIZATION AND CYTOTOXIC ANTIBACTERIAL ACTIVITY OF Ru(II) ETHOXYSALAL THIOSEMICARBAZONE COMPLEXES

Synthesis, Dna Binding, Anticancer and Cytotoxic Evaluation of Novel Ruthenium(ii) Isatin Based Schiff Base Complex

Synthesis and Characterization of Heterotrimetallic Ferrocenethiosemicarbozoneru(iii) Complexes With Asph3 for Application as an Chemotherapeutic Drug

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