Synthesis, characterization, and antimicrobial evaluation of novel spiropiperidones

Abstract

Novel spiro derivatives of piperidone 4a-f were synthesized, characterized, and screened against a panel of different bacterial and fungal strains. The study revealed the potential of these molecules for further development as antimicrobial agents.

Ultrasound Assisted Synthesis of 1,5-Diaryl and 1,3,5-Triaryl-2-pyrazolines by Using KOH/EtOH System with Cu(I) Catalyst

“…, anti-inflammatory [17], antiviral [18], antifungal [19], antiarthritic [20] properties. In reported method, substituted pyrazolines were synthesized using catalyst and solvent such as glacial acetic acid under heating or ultrasound irradiation [21], sodium hydroxide in ethyl alcohol under ultrasound irradiation [22], K2CO3-mediated microwave irradiation [23], glacial acetic acid in EtOH under microwave irradiation [24,25], EtOH [26], SOCl2 in benzene [27] under conventional heating, H3PW12O40 [28], Amberlyst 15 in refluxing toluene [29], triethanolamine [30], pyridine in refluxing ethanol [31], ethyl lactate [32] and cerium chloride heptahydrate in refluxing ethyl lactate [33]. Benzene and DMSO are the conventional solvents that have the impacts on the environment [34].…”