Synthesis, characterization and antimicrobial studies on 13-membered-N6-macrocyclic transition metal complexes containing trimethoprim

Shalini, A.S. Stella; Amaladasan, M.; Prasannabalaji, N.; Revathi, J.; Muralitharan, Gangatharan

doi:10.1016/j.arabjc.2014.11.033

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…NiTM complex has a characteristic band at 23809 cm −1 for 1 A 1 g→ 1 A 2 g transition. CuTM complex showed bands at 15847.86 cm −1 and 15600.62 cm −1 for 2 B 1 g→ 2 A 1 g, 2 B 1 g→ 2 Eg transitions so that square planar geometry suggested for Cu 2+ and Ni 2+ complexes, see Table 1 [6,[23][24]. Thermal analysis of metal complexes Table 3.…”

Section: Ultraviolet-visible Spectroscopymentioning

confidence: 99%

Synthesis and characterization of Trimethoprim metal complexes used as corrosion inhibitors for carbon steel in acid media

2019

Int. J. Corros. Scale Inhib.

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Trimethoprim (TM) is an antibiotic used to treat bacterial infections as well as it is a heterocyclic compound, whose structure consists of 1,2,3-trimethoxybenzene and pyrimidine-2,4-diamine, therefore it can be used as a corrosion inhibitor due to easy production and low price on carbon steel in acidic media by adsorption process. Cr(III), Mn(II), Co(II), Ni(II) and Cu(II) complexes of Trimethoprim were synthesized and also used as a corrosion inhibitor. The Trimethoprim drug and its complexes were characterized by different spectroscopic methods: Ultraviolet-visible, Fourier transform infrared, conductivity measurements, thermal analysis (TG) and magnetic susceptibility measurement. Adsorption process can be attributed to changes in concentration of inhibitors with the acidity of a solution as well as the surface of the metal (carbon steel). The results of the experiment have shown the coordination of the Trimethoprim drug with the transition metal ions through nitrogen of pyrimidinyl ring so that square planar geometry was suggested for Mn(II), Ni(II), Cu(II) complexes while the Cr(III), Co(II) complexes have an octahedral geometry and these complexes have electrolyte properties. Corrosion inhibition on carbon steel was studied using weight loss method in one molar hydrochloric acid solution by organic inhibitor Trimethoprim and inorganic inhibitors (complexes) at different concentrations with different periods of time. The measurements have shown that Trimethoprim reduced the corrosion of the carbon steel surface and also the inhibition efficiency of the complexes increased with increasing concentration. The inhibition efficiency followed the order Co > Cu > Cr in one molar acidic solution.

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Section: Ultraviolet-visible Spectroscopymentioning

confidence: 99%

Synthesis and characterization of Trimethoprim metal complexes used as corrosion inhibitors for carbon steel in acid media

2019

Int. J. Corros. Scale Inhib.

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Synthesis, Spectral Characterization, Antimicrobial Activity, DFT Calculations, Molecular Docking and ADME Studies of Novel Schiff Base Co(II), Ni(II), Cu(II) and Zn(II) Complexes Derived from 4‐nitro‐ortho‐phenylenediamine

Sindhu,

Singh,

Deswal

et al. 2024

Chemistry & Biodiversity

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A condensation reaction was carried out between 4‐nitro‐ortho‐phenylenediamine and 5‐bromosalicyaldehyde to synthesize a novel Schiff base ligand 2,2′‐[(1E,1′E)‐(4‐nitro‐1,2‐phenylene) bis (azaneylylidene) bis (methaneylylidene)] bis (4‐bromophenol) [NB] in the current investigation. This was followed by the synthesis of metallic complexes comprising the Co(II), Ni(II), Cu(II) and Zn(II) transition metal ions. A hexadentate environment encircling metal complexes was corroborated by the results of varied spectroscopic methods that were employed to unravel the structure of the ligand and metal complexes. The Tauc's plot and Urbach energy were utilized for quantifying the optical energy band gap to provide insight into optical characteristics. The Coats‐Redfern method of thermal analysis was implemented to do the kinetic and thermodynamic calculations. Furthermore, DFT studies were performed to predict geometrical structures and the stability of the compounds. Thorough investigation to evaluate their biological efficacies, docking studies was executed against COVID‐19 main protease (PDB‐7VAH), Dengue virus NS2B/NS3 protease (PDB‐2FOM) and Mycobacterium Tuberculosis (PDB‐5AF3). Apart from this, in silico ADMET studies were also accomplished for elucidation of drug likeness characteristics and the results attained disclose the significant proficiency of synthesized compounds. Besides this, antimicrobial studies were assessed with different microbial strains and result validates cobalt and zinc complexes as most potent against the selected bacterial and fungal strains.

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Nitro Substituted Co(II), Ni(II) and Cu(II) Schiff Base Metal complexes: design, spectral analysis, antimicrobial and in-silico molecular docking investigation

Sindhu,

Singh

2024

Biometals

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Synthesis, characterization and antimicrobial studies on 13-membered-N6-macrocyclic transition metal complexes containing trimethoprim

Cited by 4 publications

References 28 publications

Synthesis and characterization of Trimethoprim metal complexes used as corrosion inhibitors for carbon steel in acid media

Synthesis and characterization of Trimethoprim metal complexes used as corrosion inhibitors for carbon steel in acid media

Synthesis, Spectral Characterization, Antimicrobial Activity, DFT Calculations, Molecular Docking and ADME Studies of Novel Schiff Base Co(II), Ni(II), Cu(II) and Zn(II) Complexes Derived from 4‐nitro‐ortho‐phenylenediamine

Nitro Substituted Co(II), Ni(II) and Cu(II) Schiff Base Metal complexes: design, spectral analysis, antimicrobial and in-silico molecular docking investigation

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