Synthesis, characterization and antimicrobial studies on Schiff base derived from 2-aminopyridine and 2-methoxybenzaldehyde and its cobalt (ii) and nickel (ii) complexes

Antibacterial and Antifungal Activities of Schiff Base and Its Metal (Ii) Complexes of Fe (Ii), Ni (Ii) And Co (Ii) Derived From 2-Hydroxy-1-Naphthaldehyde and 2-Amino-3-Methylpyridine.

“…It was also revealed that cobalt complex showed higher activity as compared to iron and nickel complexes [14] which reported that the effect of metal ions on the biological activity of a given bio-active compound is metal specific. Both the complexes are less active than control [4]. The study also revealed that the minimum inhibitory concentration for (Staphylococcus aureus, Escherichia coli, Streptococcus pneumonia, and Klebsiella pneumoniae) of Schiff base and metal complexes was found to be 200ppm, 100ppm, 150ppm and 200ppm respectively as shown in Table 6-9.…”

“…This could be due to the fact that chelation of free ligands with metals ions selectively enhanced the biological activity of the compound [23]. The activity increases with increase in concentration of both Schiff base ligand and metal (II) complexes [4]. The activity of both Schiff base and metal (II) complexes at all concentration is less than that of control with inhibitory zone of 16mm.…”

“…The metal co mplexes on the other hand showed higher activities compared to Schiff base ligand because of chelation and π-electron delocalization, which increase the lipophilic character, favoring its permeation into the bacterial membrane, causing the death of the organisms [28]. The activities of both Schiff base and its metal (II) complexes increase as the concentration increases [4] as shown in figure 1-4. It was also revealed that cobalt complex showed higher activity as compared to iron and nickel complexes [14] which reported that the effect of metal ions on the biological activity of a given bio-active compound is metal specific.…”

“…Exactly 0.03mol (5.1654g) of 2-hydroxy-1naphthaldehyde was mixed with 0.03mol (3.023ml) of 2-amino-3-methylpyridine in 50 cm 3 of ethanol. The mixture was heated under reflux at 70 o C-80 o C for 3hours and the solid product formed was separated by filtration, purified by recrystallization from ethanol, washed with ethanol, and then dried in desiccators over calcium chloride (cacl2) for 18hrs [4].…”

“…Schiff base is an imine or azomethine containing compound which was first reported by Hugo Schiff in 1864. It is considered as ligand due to its ability to donate a lone pair of electron to the central metal atom and it could be mono, Di,or polydentate ligand depending on the number of donor site it contain [4].…”