Synthesis, Characterization and Antimicrobial Studies of Some New Tellurium(IV) Complexes Derived from 2-[(2-Hydroxyphenyl)imino methyl]-1-naphthol Schiff Base

Abstract

This article reports the synthesis, characterization and antimicrobial screening of a tridentate 2-[(2-hydroxyphenyl)imino methyl]-1-naphthol ligand (H2AP) and its organotellurium(IV) complexes. Structural characterization of the synthesized ligand and complexes was confirmed by using FT-IR, 1H NMR, 13C NMR, UV-vis, mass spectrometry, molar conductance and elemental analysis. Geometry of all the synthesized compounds has been optimized and their DFT based chemical reactivity descriptors were calculated. DFT and spectral data studies revealed distorted square pyramidal geometry for the tellurium(IV) complexes. In vitro antimicrobial activities of the synthesized ligand and its tellurium(IV)complexes were evaluated against two Gram-positive, two Gram-negative bacterial strains and three fungal strains. The tellurium(IV) complexes exhibited promising activity as compared to the Schiff base ligand.

Exploring the antimicrobial, antioxidant and cytotoxic activities of organyltellurium (IV) complexes incorporating 2‐hydroxy‐1‐naphthaldehyde schiff base ligand: Synthesis, spectroscopic investigations and theoretical studies

“…We assessed the structure-activity relationship to understand the impact of the synthesized compounds on pharmacological activity (supplementary Figure S29). Literature study [35][36][37][38]40,80 revealed that the attached groups of the moiety significantly affect the antimicrobial, antioxidant and anti-cancer activities. Therefore, we synthesized various group based organyltellurium complexes for comparing their pharmacological activities.…”

“…[20][21][22] In addition to synthetic applications, 1,3-diaminopropane has been reported to possess antibiotic activities, 23,24 making it a useful building block for the synthesis of bioactive molecules, including drugs and enzyme inhibitors. Moreover, the complexation of Schiff base ligands with metals, especially with tellurium (IV) metal has attracted researcher because of their wide range of applications, including their use as medicine, [25][26][27][28][29][30] chemical sensors, 31,32 porous materials and as a colorimetric probe for metal ion detection 33 because tellurium halides exhibit Lewis acid character and form stable chelates 34,35 with a variety of Schiff base ligands. The incorporation of tellurium (IV) metal ion into Schiff base ligands has been observed to enhance their bioactivities which demonstrated a broad spectrum of biological activities such as anthelminthic, 36 anti-tubercular, 37 immuno-modulatory 38 and antioxidant 39 etc.…”