Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives

Physical and Structural Characterization of Biofield Treated Imidazole Derivatives

“…GC-MS data revealed that isotopic abundance ratio of either 13 good inhibition against various tested microbial strains. Vijesh et al reported that some of the imidazole derivatives (3-aryl-1H-imidazole-4-carbaldehyde thiosemicarbazones) have excellent activity even better than standard drug, i.e., streptomycin against Pseudomonas aeruginosa and Clostridium perfringens [4]. Ucucu et al had reported that synthetic 1-benzyl-2-substituted-4,5-diphenyl-1H-imidazole derivative worked well as analgesic on Swiss albino mice of both sexes.…”

2-(chromon-3-yl)imidazole derivatives as potential antimicrobial agents: synthesis, biological evaluation and molecular docking studies

“…The 1 H NMR spectrum of compound (4a) showed doublet of doublets of the chromone ring proton C5′-H at δ 8.30 and signal of -NH of imidazole ring appeared as singlet at δ 9.18, which was further corroborated through a sharp band at 3342 cm −1 in its IR spectrum. 13 C NMR spectrum of 4a showed resonance at δ 176.2 ppm attributed to carbonyl group of chromone ring, which was further confirmed by IR spectrum through band at 1643 cm −1 . The mass spectrum of 4a showed peak at m/z 365 (M + H) + 13 C NMR spectrum of compound 6a showed resonance at δ 174.7 ppm attributed to carbonyl group of chromone ring, which is further confirmed by its IR spectrum through band appeared at 1650 cm −1 ; its mass spectrum showed the molecular ion peak at m/z 405.1 (M + H) + , which corresponds to the molecular formula of 6a.…”

“…According to literature reports, clinically used azoles such as clotrimazole, miconazole and econazole containing imidazole nucleus exhibit significant antimicrobial spectrum though inhibition of enzyme lanosterol 14α-demethylase [12]. Various imidazole-based lead compounds such as 3-aryl-4-(4,5-diphenyl-1H-imidazol-2-yl)-1H-pyrazole [13], N-(4-aryl-1H-imidazol-2-yl)cinnamamide [14] and substituted 1-[2-(1H-imidazol-1-yl)acetyl]-2,6-diarylpiperidin-4-one [15] have also been screened for in vitro antibacterial and antifungal activities against various pathogenic microbial strains and displayed promising inhibitory potential.…”

Synthesis, Characterization, and Biological Evaluation of Some Tri‐Substituted Imidazole/thiazole Derivatives

“…The well-acknowledged examples of imidazole derivatives are amino acid histidines and their usage of their representatives such as the hypnotic agent etomidate [1], the anti-ulcerative agent cimetidine [2], the proton pump inhibitor omeprazole [3], the fungicide ketoconazole [4], and the benzodiazepine antagonist flumazenil [5]. In addition to that, imidazole derivatives are also known as antibacterial [6][7][8][9], anti-TB [10,11], anticonvulsant [12], antileishmanial [13], anticancer [14,15], anti-inflammatory agent [16,17], and also as pesticide [18,19]. In present times, substituted imidazoles are considerably used for the synthesis of ionic liquids [20].…”

“…H NMR spectra of the compound (3b), a singlet peak appeared at d = 12.4, which was due to the presence of ─NH group in imidazole ring, and another singlet peak at d = 8.2 was due to the C (34) = ─CH in the pyrazole structure. The spectra show multiplet peaks at d = 7.969 to 7.243 for the different pairs of carbons, for example, C (34) -C (29) , C (25) -C (23) , C (18) -C (14) , and C (7) , which has chemically equivalent protons. Singlet peak at d = 2.3 indicates the presence of C (35) as ─CH 3 group.…”