Synthesis, Characterization and Antioxidant Activity of Carvacrol Based Sulfonates

Bagul, Suresh D.; Rajput, Jamatsing D.; Patil, Manohar; Bendre, Ratnamala S.

doi:10.4172/2161-0444.1000470

Med chem

2017

DOI: 10.4172/2161-0444.1000470

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Synthesis, Characterization and Antioxidant Activity of Carvacrol Based Sulfonates

Suresh D. Bagul¹,

Jamatsing D. Rajput²,

Manohar Patil³

et al.

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2024

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Cited by 2 publications

References 28 publications

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Synthesis and Antiproliferative Properties of Some Spirocyclic Pyrimidine Hydrazones

Ragab,

Sweed,

Srour

2024

ChemistrySelect

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A new series of hydrazone derivatives incorporating spirocyclic aminopyrimidine with aryl alkanesulfonates were synthesized. The targeted products were obtained in excellent yields via an acid catalyzed reaction of spirocyclic hydrazinopyrimidine with aryl aldehyde sulfonates. The structures of the synthesized hydrazones were studied by the different spectroscopic tools, in addition to the high resolution mass analysis. The antiproliferative activities of the compounds were tested in vitro against the National Cancer Institute (NCI) 60 cell panel by the Developmental Therapeutics Program. Amongst the tested hydrazone compounds, the methansulfonate derivatives showed the highest activities against lung, brain, kidney, and breast cancers.

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Synthesis and Antiproliferative Properties of Some Spirocyclic Pyrimidine Hydrazones

Ragab,

Sweed,

Srour

2024

ChemistrySelect

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Synthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers

et al. 2022

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In the present study, the various 28 hybrid molecules containing hydrazone and sulfonate moiety were synthesized and characterized by FTIR, 1 H-NMR, 13 C-NMR spectroscopy and LC-MS spectrometry, besides elemental analysis. The compounds were evaluated for their antiproliferative effects against six cancer cell lines, namely A549 (non-small cell lung cancer), MCF-7 (breast cancer), HT-29 (colorectal adenocarcinoma cancer), PC-3 (androgen-independent prostate adenocarcinoma), Hep3B (hepatocellular carcinoma cancer), and HeLa (epitheloid cervix carcinoma cancer). Among all the target compounds, compounds 4g and 4h exhibited more promising effects on MCF-7 cell lines (IC 50 =17.8 mM and 21.2 mM, respectively) with high selectivity. Further mechanistic studies proposed that compounds 4g and 4h induced apoptosis is mediated through the intrinsic apoptotic pathway with changes in mitochondrial membrane potential by nally activating caspase-9 and caspase-3. The results have been encouraging enough to merit further investigation.

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Synthesis, Characterization and Antioxidant Activity of Carvacrol Based Sulfonates

Cited by 2 publications

References 28 publications

Synthesis and Antiproliferative Properties of Some Spirocyclic Pyrimidine Hydrazones

Synthesis and Antiproliferative Properties of Some Spirocyclic Pyrimidine Hydrazones

Synthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers

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