Synthesis, Characterization and Antitumor Mechanism Investigation of Heterometallic Ru(Ⅱ)-Re(Ⅰ) Complexes

Ma, Xiu-Rong; Lu, Junjian; Yang, Peixin; Huang, Bo; Li, Rong‐Tao; Ye, Rui-Rong

doi:10.3389/fchem.2022.890925

Cited by 7 publications

(4 citation statements)

References 72 publications

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“…A series of heterometallic gold(I) and platinum(II) complexes with a new bipyridylamine-phosphine ligand display antiproliferative properties in vitro in human cancer cells in the range of cisplatin or higher, 4 while heterometallic complexes based on Ru(II) and Re(I) units exhibit higher anticancer activity than cisplatin, and exert certain selectivity toward human cancer cells over normal cells. 5 Interaction studies of carbonyl heterometallic Ru(II) and Fe(II) complexes containing polypyridyl ligands have not shown correlation between the increase of the π framework extension of the polypyridyl ligand on the effect on cell viability in tumorigenic and non-tumorigenic cell lines. 6 The ruthenium-gold (Ru-Au) heterometallic complexes based on Au-N-heterocyclic carbene (NHC) were investigated in vitro in human clear cell renal carcinoma cell line (Caki-1).…”

Section: Introductionmentioning

confidence: 99%

Heterometallic bridged Pt(II)‐Zn(II) complexes: Influence of the substituent in 4′‐position in inert terpy ligand on antigenotoxicity, potential antitumor activity and mechanism of interactions of the complexes with biomolecules

Serezlić,

Hasić,

Ašanin

et al. 2024

Applied Organom Chemis

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The synthesis and characterization of novel hetrometallic complexes [{cis‐PtCl(NH3)2(μ‐4,4′‐bipyridyl)ZnCl(terpy‐Cl)}](ClO4)2 (C1a), [{trans‐PtCl(NH3)2(μ‐4,4′‐bipyridyl)ZnCl(terpy)}](ClO4)2 (C2a), [{cis‐PtCl(NH3)2(μ‐pyrazine)ZnCl(terpy‐Cl)}](ClO4)2 (C3a) and [{trans‐PtCl(NH3)2(μ‐pyrazine)ZnCl(terpy‐Cl)}](ClO4)2 (C4a) (where terpy‐Cl = 4′‐chloro‐2,2′:6′,2′′‐terpyridine) was done. Acid–base titrations were performed by UV–Vis spectrophotometric method to evaluate the pKa values of corresponding aqua complexes. Interactions between complexes and important biomolecules, guanosine‐5′‐monophosphate (5′‐GMP) and glutathione (GSH) were examined by 1H NMR spectroscopy. The chloride substituent at the 4′ position on the middle pyridine ring of terpyridine ligand significantly affects the coordination of biomolecules, as well as overall stability of complexes. The complexes were evaluated in vitro for the antioxidant prevention of DNA damages. All tested novel complexes demonstrated a significant reduction in DNA damage against oxidative modifications of DNA caused by the hydroxyl and peroxyl radicals. Also, cytotoxicity evaluation showed that significant cytotoxicity occurs only after long‐term effect of C1a, C2a and C3a, complexes in HCT‐116 cells. Molecular docking studies predict results in agreement with experimental research.

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Section: Introductionmentioning

confidence: 99%

Heterometallic bridged Pt(II)‐Zn(II) complexes: Influence of the substituent in 4′‐position in inert terpy ligand on antigenotoxicity, potential antitumor activity and mechanism of interactions of the complexes with biomolecules

Serezlić,

Hasić,

Ašanin

et al. 2024

Applied Organom Chemis

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“…Cytotoxicity assay shows that ruthenium(II)/rhenium(I) also exhibits higher anticancer activity than cisplatin. The complexes induce apoptosis through the regulation of the cell cycle, depolarization of mitochondrial membrane potential elevation of intracellular reactive oxygen species, and caspase cascade [ 14 ]. The new platinum(IV)/ruthenium(II) complexes, which combine the cytotoxic properties of cisplatin with the antimetastatic characteristics of ruthenium–arene complexes, were found to exhibit higher cytotoxicity compared to cisplatin.…”

Section: Introductionmentioning

confidence: 99%

Modes of Interactions with DNA/HSA Biomolecules and Comparative Cytotoxic Studies of Newly Synthesized Mononuclear Zinc(II) and Heteronuclear Platinum(II)/Zinc(II) Complexes toward Colorectal Cancer Cells

Vučelj,

Hasić,

Ašanin

et al. 2024

IJMS

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A series of mono- and heteronuclear platinum(II) and zinc(II) complexes with 4,4′,4″-tri-tert-butyl-2,2′:6′,2″-terpyridine ligand were synthesized and characterized. The DNA and protein binding properties of [ZnCl2(terpytBu)] (C1), [{cis-PtCl(NH3)2(μ-pyrazine)ZnCl(terpytBu)}](ClO4)2 (C2), [{trans-PtCl(NH3)2(μ-pyrazine)ZnCl(terpytBu)}](ClO4)2 (C3), [{cis-PtCl(NH3)2(μ-4,4′-bipyridyl)ZnCl(terpytBu)}](CIO4)2 (C4) and [{trans-PtCl(NH3)2(μ-4,4′-bipyridyl)ZnCl(terpytBu)}](CIO4)2 (C5) (where terpytBu = 4,4′,4″-tri-tert-butyl-2,2′:6′,2″-terpyridine), were investigated by electronic absorption, fluorescence spectroscopic, and molecular docking methods. Complexes featuring transplatin exhibited lower Kb and Ksv constant values compared to cisplatin analogs. The lowest Ksv value belonged to complex C1, while C4 exhibited the highest. Molecular docking studies reveal that the binding of complex C1 to DNA is due to van der Waals forces, while that of C2–C5 is due to conventional hydrogen bonds and van der Waals forces. The tested complexes exhibited variable cytotoxicity toward mouse colorectal carcinoma (CT26), human colorectal carcinoma (HCT116 and SW480), and non-cancerous mouse mesenchymal stem cells (mMSC). Particularly, the mononuclear C1 complex showed pronounced selectivity toward cancer cells over non-cancerous mMSC. The C1 complex notably induced apoptosis in CT26 cells, effectively arrested the cell cycle in the G0/G1 phase, and selectively down-regulated Cyclin D.

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“…Besides the mentioned inhibitors above, metal complexes have been applied to reduce side effects and improve the selectivity of molecules to MMPs. Along with the multiple metal complexes that have anti-tumor ability targeting DNA/RNA or mitochondria and anti-Aβ aggregation ability to reduce the risk of onset and/or progression of cancers and AD [ 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 ], various metal complexes (e.g., Pt-, Ru-, Fe-, Cu-, Au-, Ni-, Zn, Sn-complexes) could be applied as regulators for both expression and enzymatic activity of MMPs. Those metal complexes could be applied as cancer and AD treatments later.…”

Section: Introductionmentioning

confidence: 99%

Metal Complexes as Promising Matrix Metalloproteinases Regulators

Nguyen

Kim

Lee

2023

IJMS

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Nowadays, cancers and dementia, such as Alzheimer’s disease, are the most fatal causes of death. Many studies tried to understand the pathogenesis of those diseases clearly and develop a promising way to treat the diseases. Matrix metalloproteinases (MMPs) have been reported to be involved in the pathology of cancers and AD through tumor cell movement and amyloid degradation. Therefore, control of the levels and actions of MMPs, especially MMP-2 and MMP-9, is necessary to care for and/or cure cancer and AD. Various molecules have been examined for their potential application as regulators of MMPs expression and activity. Among the molecules, multiple metal complexes have shown advantages, including simple synthesis, less toxicity and specificity toward MMPs in cancer cells or in the brain. In this review, we summarize the recent studies and knowledge of metal complexes (e.g., Pt-, Ru-, Au-, Fe-, Cu-, Ni-, Zn-, and Sn-complexes) targeting MMPs and their potentials for treating and/or caring the most fatal human diseases, cancers and AD.

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Synthesis, Characterization and Antitumor Mechanism Investigation of Heterometallic Ru(Ⅱ)-Re(Ⅰ) Complexes

Cited by 7 publications

References 72 publications

Heterometallic bridged Pt(II)‐Zn(II) complexes: Influence of the substituent in 4′‐position in inert terpy ligand on antigenotoxicity, potential antitumor activity and mechanism of interactions of the complexes with biomolecules

Heterometallic bridged Pt(II)‐Zn(II) complexes: Influence of the substituent in 4′‐position in inert terpy ligand on antigenotoxicity, potential antitumor activity and mechanism of interactions of the complexes with biomolecules

Modes of Interactions with DNA/HSA Biomolecules and Comparative Cytotoxic Studies of Newly Synthesized Mononuclear Zinc(II) and Heteronuclear Platinum(II)/Zinc(II) Complexes toward Colorectal Cancer Cells

Metal Complexes as Promising Matrix Metalloproteinases Regulators

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