Synthesis, Characterization, and Application of Iodoacetamide Derivatives Utilized for the ALiPHAT Strategy

Williams, D. Keith; Meadows, Corey W.; Bori, Ibrahim D.; Hawkridge, Adam M.; Comins, Daniel L.; Muddiman, David C.

doi:10.1021/ja076849y

Cited by 45 publications

(56 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2-Iodo-N-octylacetamide was firstly synthesized and further used for the derivatization of cysteine-containing peptides and the ESI response of laminin nonapeptide and B-type natriuretic peptides-32 were respectively increased by 3 and 2-fold [26] . Subsequently, 2-iodo-N-(4-phenylbutyl)-acetamide was synthesized and the ESI ionization efficiency of peptides Ac-ALCDDPRVDRWY CQFVEG-NH 2 and CYFQNCPRG-NH 2 were respectively improved over 400 and 2000-fold via derivatization, outperforming carboxyamidomethyl-modified counterparts [27] .…”

Section: Derivatization Of Thiol Groupmentioning

confidence: 99%

Recent Advancement of Chemical Derivatization and Its Applications to High Sensitive Analysis of Peptide in Mass Spectrometry

Qiao¹,

Wang²,

Zhang³

et al. 2013

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY (CHINESE VERSION)

View full text Add to dashboard Cite

Abstract:Shotgun based strategy is a widely used method in proteome research. However, due to the high complexity and wide dynamic range, the detection sensitivity of peptides, especially for those with low abundance and low ionization efficiency, still can hardly meet the requirements. Chemical derivatization has been proved to be one of the most promising methods. Herein, the recent progress in the development of derivatization reagents targeting for the peptides as well as those with post-translational modifications, and its applications in high sensitive analysis in mass spectrometry are reviewed. Furthermore, the future research directions and the potential application in proteome research are discussed.

show abstract

Section: Derivatization Of Thiol Groupmentioning

confidence: 99%

Recent Advancement of Chemical Derivatization and Its Applications to High Sensitive Analysis of Peptide in Mass Spectrometry

Qiao¹,

Wang²,

Zhang³

et al. 2013

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY (CHINESE VERSION)

View full text Add to dashboard Cite

show abstract

Section: Derivatization Of Thiol Groupmentioning

confidence: 99%

Recent Advancement of Chemical Derivatization and Its Applications to High Sensitive Analysis of Peptide in Mass Spectrometry

Qiao

Rui

Zhang

et al. 2012

Chinese Journal of Analytical Chemistry

View full text Add to dashboard Cite

“…In addition, it was observed that an increase in the aliphatic chain length increased mass spectral signal intensity, although this enhancement was peptide sequence dependent (data not shown). This was likely due to the increased hydrophobicity of modified peptides [31][32][33][34]. Enhanced signals should also be beneficial to mass spectrometry of phosphopeptides, which are often substoichiometric and of low abundance.…”

Section: Effects Of Esterification On the Specificity Of Phosphoryl Fmentioning

confidence: 99%

Shifting unoccupied spectral space in mass spectrum of peptide fragment ions

Bajrami

Shi

Lapierre

et al. 2009

J. Am. Soc. Mass Spectrom.

View full text Add to dashboard Cite

Synthesis, Characterization, and Application of Iodoacetamide Derivatives Utilized for the ALiPHAT Strategy

Cited by 45 publications

References 9 publications

Recent Advancement of Chemical Derivatization and Its Applications to High Sensitive Analysis of Peptide in Mass Spectrometry

Recent Advancement of Chemical Derivatization and Its Applications to High Sensitive Analysis of Peptide in Mass Spectrometry

Recent Advancement of Chemical Derivatization and Its Applications to High Sensitive Analysis of Peptide in Mass Spectrometry

Shifting unoccupied spectral space in mass spectrum of peptide fragment ions

Contact Info

Product

Resources

About