Synthesis, characterization and bioactivities of a new covalent copper(II) compound derived from {P2Mo5O23}6− and thiosemicarbazones

Zhao, Haiyan; Li, Jie; Fang, Yan; Chang, Bowen; Meng, Qingxi; Li, Mingxue; Wang, Chunzhang; Zhu, Xuemei

doi:10.1016/j.bmcl.2019.126781

Cited by 6 publications

(1 citation statement)

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“…Quite recently, a Cu(II) hybrid system containing a polyoxometalate moiety and a 2-acetylpyrazine-TSC NN S chelator was proven to exhibit antibacterial activity against Escherichia coli and Staphilococcus aureus and a better cytotoxicity against human hepatic cancer cells (SMMC-7721) than Mitoxantone, the current chemical anticancer drug, with an IC 50 value of about 1.6 µg/mL [84].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Biological Activity of Novel Cu(II) Complexes of 6-Methyl-2-Oxo-1,2-Dihydroquinoline-3-Carbaldehyde-4n-Substituted Thiosemicarbazones

et al. 2020

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Three new 6-methyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde-thiosemicarbazones-N-4-substituted pro-ligands and their Cu(II) complexes (1, -NH2; 2, -NHMe; 3, -NHEt) have been prepared and characterized. In both the X-ray structures of 1 and 3, two crystallographically independent complex molecules were found that differ either in the nature of weakly metal-binding species (water in 1a and nitrate in 1b) or in the co-ligand (water in 3a and methanol in 3b). Electron Paramagnetic Resonance (EPR) measurements carried out on complexes 1 and 3 confirmed the presence of such different species in the solution. The electrochemical behavior of the pro-ligands and of the complexes was investigated, as well as their biological activity. Complexes 2 and 3 exhibited a high cytotoxicity against human tumor cells and 3D spheroids derived from solid tumors, related to the high cellular uptake. Complexes 2 and 3 also showed a high selectivity towards cancerous cell lines with respect to non-cancerous cell lines and were able to circumvent cisplatin resistance. Via the Transmission Electron Microscopy (TEM) imaging technique, preliminary insights into the biological activity of copper complexes were obtained.

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Section: Introductionmentioning

confidence: 99%