Synthesis, Characterization and Bioactivity of 1,1-bis(2-Carbamoylguanidino)furan-2-ylmethane

Don-Lawson, Dr. Chioma; Nweneka, Daniel Okechukwu; Okah, Reminus; Orie, Kingsley John

doi:10.4236/ajac.2020.116020

Cited by 4 publications

(5 citation statements)

References 5 publications

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“…The well in Agar diffusion method with Dextrose Agar was used for this test and is in-line with Don-lawson et al [26]. The medium was prepared according to the manufacturer's standard.…”

Section: Fungal Sensitivity Testmentioning

confidence: 99%

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Characterization and Antimicrobial Profiling of Ethanol-Toluene Extract of Pentaclethra macrophylla Benth Pod

Nsude

Orie

2023

AJACR

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The research reports the characterization and antimicrobial profiling of an ethanol-toluene extract of the Pentaclethra macrophylla Benth pod. The sample was powdered and extracted with a solvent system of ethanol-toluene (2:1). The extract was characterized with Fourier transform infrared (FTIR) spectroscopy and Gas Chromatographic-Mass Spectrometric (GC-MS) analysis, as well as a wet analysis investigation. The qualitative and quantitative analysis reveals the presence of flavonoids (0.307), phenols (0.4545), alkaloids (1.7165), tannins (6.118), saponins (5.700), and glycosides (0.2375). The FTIR revealed the presence of 1723cm-1, which was assigned to carbonyl groups, and the peaks within the range of 3416.10–3777.54cm-1 were attributed to hydroxyl groups. The GC-MS reveals the presence of 34 molecules in the chromatogram, which is consistent with the mass spectra. The ethanol-toluene extract contains 19 guaiacyl and its derivatives, as well as 15 syringyl and its derivatives. The molecule, propenylsyringol (cis)b has the highest yield based on the height of the peak. Other lignin-derived molecules with a good percentage of extraction were vanillin, syringaldehyde and synapylalcohol (cis). The antimicrobial analysis of the extract was tested on nine pathogens (Staphylococcus aureus, Proteus bacilli, Streptococcus pyogenes, Escherichia coli, Candida species, Aspergillus Niger, Penicillium spp., Fusarium spp., and Aspergillus fumigates). The result therefore reveals that the ethanol-toluene extract of PMBP was more effective on S. pyogenes (0.9mm), P. bacilli (0.5 mm), and Fusarium spp. (0.9mm) at the MIC of 6.25mg/mL. The standard antimicrobial agents, Focknazol (antifungal) and Ciprotab (antibacterial), have the highest zone inhibition at an MIC of 6.25mg/mL, when compared with the ethanol-toluene extract of Pentaclethra macrophylla Benth pod. The ethanol-toluene extract of the Pentaclethra macrophylla Benth pod can be used as a source of guaiacyl or syringyl derivatives and also clinically since it is sensitive to some pathogens.

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“…The well in Agar diffusion method with Dextrose Agar was used for this test and is in-line with Don-lawson et al [26]. The medium was prepared according to the manufacturer's standard.…”

Section: Fungal Sensitivity Testmentioning

confidence: 99%

“…The peak at 1030cm , was assigned to aromatic CH deformation, etc. The peak at 1723cm -1 was assigned to carbonyl groups [26][27][28]. This might be due to the increase of products like 5, 21, 22, 23, and 24 (Table 2).…”

Section: Ftir Analysis Of Ethanol-toluene Extract Of Pentaclethra Mac...mentioning

confidence: 99%

Characterization and Antimicrobial Profiling of Ethanol-Toluene Extract of Pentaclethra macrophylla Benth Pod

Nsude

Orie

2023

AJACR

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“…The phytochemical screening of the root extract of Phyllanthus mellerianus (nvo nkwu) was investigated using the same adopted by Edeoga et al [1], Larayetan et al [3], Don-Lawson et al [6], Nsude and Orie [10] and Ogbuanu et al [18]…”

Section: Phytochemical Srceening Of the Inhibitor Phyllanthus Melleri...mentioning

confidence: 99%

“…Phytochemicals are important compounds found in medicinal plants that are not essential for the normal functioning of the human body, but are active and exert beneficial effects on health or in the amelioration of diseases. Although many phytochemicals are already known, many are yet to be identified [5,6].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Constituent and Anti-corrosion Properties of the Root Extract of Phyllanthus mellerianus (Nvo-nkwu) Plant on Mild Steel in 1.5M HCl Medium

Nsude

Orie

2022

CSIJ

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The research reports on the phytochemical constituents and anti-corrosion properties of the root extract of Phyllanthus mellerianus on mild steel in 1.5M HCl. The powdered root was extracted with ethanol and concentrated with a rotary evaporator. The phytochemical constituents’ were achieved through GC-MS, FTIR and wet analysis. The anticorrosion properties were investigated via weight loss, hydrogen evolution techniques, and SEM analysis. The phytochemical investigation reveals the presence of tannins, flavonoids, phenols, and terpenoids at reasonable percentages. At different temperatures of 303K, 313K, and 323K, the inhibition efficiency, enthalpy, entropy, activation energy, Gibbs free energy, and adsorption isotherms were extrapolated with some models. The inhibition efficiency increased with an increase in the concentration of the extract, an indication of the inhibitive property of the root extract. This was supported through the extrapolation of Gibbs free energy, activation energy, enthalpy, and entropy change. The thermodynamic variable shows that the mechanism of inhibition was physisorption, whereas the kinetics study confirmed a first-order kinetic on the corrosion of mild steel in hydrochloric acid. The values of the linear regression R2 confirm the inhibitive impact of the root extract on mild steel in an acid medium. The presence of the heteroatoms N, O, and S in the root extracts of Phyllanthus mellerianus has been attributed to their inhibitory effectiveness.

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“…Currently, there are more than 10 furan drugs in clinical application. 19 In 2021, Liu et al presented a novel synthesis method of polyhydroxyalkyl furans, which is based on the lipase-catalyzed Knoevenagel/oxo-Michael/Thorpe-Ziegler cascade reaction in pure water. 20 This method used reducing sugars and malononitrile as substrates, selected various lipases, such as lipase B from Candida antarctica (CALB), Pseudomonas cepacia lipase (PSL), Novozym435 (immobilized CALB), PPL as well as CRL, as catalysts, and acquired moderated to good yield (55-88%) (►Scheme 4A).…”

Section: Synthesis Of Five-membered Heterocyclic Compounds Containing Oxygenmentioning

confidence: 99%

Progress in the Synthesis of Heterocyclic Compounds Catalyzed by Lipases

Wang

Shen

et al. 2021

Pharmaceutical Fronts

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Heterocyclic compounds are representative of a larger class of organic compounds, and worthy of attention for many reasons, chief of which is the participation of heterocyclic scaffolds in the skeleton structure of many drugs. Lipases are enzymes with catalytic versatility, and play a key role in catalyzing the reaction of carbon–carbon bond formation, allowing the production of different compounds. This article reviewed the lipase-catalyzed aldol reaction, Knoevenagel reaction, Michael reaction, Mannich reaction, etc., in the synthesis of several classes of heterocyclic compounds with important physiological and pharmacological activities, and also prospected the research focus in lipase-catalyzed chemistry transformations in the future.

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Synthesis, Characterization and Bioactivity of 1,1-bis(2-Carbamoylguanidino)furan-2-ylmethane

Cited by 4 publications

References 5 publications

Characterization and Antimicrobial Profiling of Ethanol-Toluene Extract of Pentaclethra macrophylla Benth Pod

Characterization and Antimicrobial Profiling of Ethanol-Toluene Extract of Pentaclethra macrophylla Benth Pod

Phytochemical Constituent and Anti-corrosion Properties of the Root Extract of Phyllanthus mellerianus (Nvo-nkwu) Plant on Mild Steel in 1.5M HCl Medium

Progress in the Synthesis of Heterocyclic Compounds Catalyzed by Lipases

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