Synthesis, characterization and biocompatibility of polypyrrole/Cu(II) metal-organic framework nanocomposites

Neisi, Zeinab; Ansari-Asl, Zeinab; Jafarinejad-Farsangi, Saeideh; Tarzi, Mojdeh Esmaeili; Sedaghat, Tahereh; Nobakht, Valiollah

doi:10.1016/j.colsurfb.2019.03.032

Cited by 35 publications

(17 citation statements)

References 64 publications

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“…The expression of proinflammatory genes was decreased in groups treated with PPy/x%Co-MOF nanocomposites, but it was not statistically significant compared to control. As reported in previous work, PPy/x%Cu-MOF nanocomposites did not change the expression of COX-2 and iNOS in J774.A1 cell line [41]. In response to inflammation challenge, expression of 2 important proinflammatory enzymes increased in macrophages as an important part of an innate immune system.…”

Section: The Effect Of Nanocomposites On the Mrna Levels Of Cox-2 Andsupporting

confidence: 74%

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Fabrication and biocompatibility assessment of polypyrrole/cobalt(II) metal-organic frameworks nanocomposites

Mehrabani¹,

Ansari-Asl²,

Rostamzadeh³

et al. 2020

Turk J Chem

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Nowadays, metal-organic frameworks (MOFs) have emerged as promising tools for different biological applications and therefore, efforts are ongoing to develop more biocompatible MOFs-based nanocomposites. We aimed to fabricate some new conductive nanocomposites of polypyrrole and cobalt-MOF with different weight percentages (PPy/x%Co-MOF) using the solution mixing method and characterize them through FT-IR (Fourier-transform infrared), PXRD (powder X-ray diffraction), SEM (scanning electron microscope), and TEM (transmission electron microscope) techniques. The biocompatibility of nanocomposites was assessed by haemolytic, cytotoxic, and quantitative reverse transcription PCR (qRT-PCR) assays. FT-IR and PXRD results revealed that nanocomposites consisted of pure MOFs and PPy. Moreover, SEM results indicated their spherical morphology along with an average diameter of 190 nm. (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed a concentration, and percentagedependent cytotoxic effect of the nanocomposites on some cell lines including 3T3 fibroblasts, MCF-7, and J774.A1 macrophages. Haematological toxicity of PPy/x%Co-MOF composites was less than 7% in most concentrations. Furthermore, PPy/x%Co-MOF composites did not show any significant effect on the expression of cyclooxygenase − 2 (COX-2) and inducible nitric oxide synthase (iNOS) genes. In sum, regarding the haemolytic, proinflammatory, and cytotoxic tests, prepared nanocomposite demonstrated the reasonable in vitro biocompatibility which may be considered as a hopeful platform for further investigations including clinical applications.

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Section: The Effect Of Nanocomposites On the Mrna Levels Of Cox-2 Andsupporting

confidence: 74%

“…Polypyrrole was prepared based on our previous study [41]. Nanocomposites were obtained through the same synthetic procedure.…”

Section: Preparation and Characterization Of Ppy And Ppy/x% Co-mof Namentioning

confidence: 99%

Fabrication and biocompatibility assessment of polypyrrole/cobalt(II) metal-organic frameworks nanocomposites

Mehrabani¹,

Ansari-Asl²,

Rostamzadeh³

et al. 2020

Turk J Chem

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“…Metal-organic frameworks are a new hybrid materials family, based on coordinated complexes of molecules, with interesting properties for anti-inflammatory drug loading such as high porosity and crystallinity. [126] However, the toxicity of those materials remains high because of the presence of organic linkers that are not biocompatible. [127] Abuçafy et al [127] synthetized a new metalorganic framework with cyclodextrin as organic linker in order to improve the biocompatibility of those coordinated particles.…”

Section: Nanoparticlesmentioning

confidence: 99%

“…Other drugs and systems based on nanoparticles that are biocompatible and anti-inflammatory were proposed in the last years. [126,128] For instance, Neisi et al [126] used polypyrrole as organic linkers to create a copper metallic-organic framework biomaterial with good in vitro and in vivo biocompatibility. Moreover, the loading of curcumin into the pores delivered an anti-inflammatory activity.…”

Section: Nanoparticlesmentioning

confidence: 99%

Recent Advances in Antiinflammatory Material Design

Lebaudy

Fournel

Lavalle

et al. 2020

Adv Healthcare Materials

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Implants and prostheses are widely used to replace damaged tissues or to treat various diseases. However, besides the risk of bacterial or fungal infection, an inflammatory response usually occurs. Here, recent progress in the field of anti‐inflammatory biomaterials is described. Different materials and approaches are used to decrease the inflammatory response, including hydrogels, nanoparticles, implant surface coating by polymers, and a variety of systems for anti‐inflammatory drug delivery. Complex multifunctional systems dealing with inflammation, microbial infection, bone regeneration, or angiogenesis are also described. New promising stimuli‐responsive systems, such as pH‐ and temperature‐responsive materials, are also being developed that would enable an “intelligent” antiinflammatory response when the inflammation occurs. Together, different approaches hold promise for creation of novel multifunctional smart materials allowing better implant integration and tissue regeneration.

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“…24 Hybridization of polypyrrole (PPy) with various MOFs has been extensively studied in last few years, providing working materials as electrodes for sensors (CuTRZMoO 4 @PPy-n), electrocatalysts in CO 2 reduction (MgNi-MOF-74/PPy), water deionization membranes (ZIF-67/PPy), metal ion-selective membranes (HKUST-1/PPy), imaging and chemo-thermal cancer therapy (MIL-100(Fe)/PPy), optoelectronics ([Cd(NDC) 0.5 (PCA)]/PPy), various biomedical applications, and energy storage (ZIF-67-S/ PPy). [24][25][26][27][28][29][30][31] Particularly, in the past two years, MOF-reinforced PPy have been tested as electrode materials in supercapacitors. Taking advantage of both their large surface area and good electrical conductivity, these combined materials demonstrated very promising characteristics.…”

Section: Introductionmentioning

confidence: 99%