Synthesis Characterization and Biological Activities of Coordination Compounds of 4-Hydroxy-3-nitro-2<i>H</i>-chromen-2-one and Its Aminoethanoic Acid and Pyrrolidine-2-carboxylic Acid Mixed Ligand Complexes

Aiyelabola, Temitayo O.; Akinkunmi, Ezekiel Olugbenga; Obuotor, Efere Martins; Olawuni, Idowu Julius; Isabirye, David A.; Jordaan, Johannes H.

doi:10.1155/2017/6426747

Cited by 18 publications

(15 citation statements)

References 52 publications

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“…Although there are a number of anti-inflammatory drugs currently in the market, however, they exhibit significant adverse effects. In this respect, coordi-nation chemistry may be deemed as a useful tool in curbing this [36] [37] [38] [39]. Earlier investigations have revealed that coordination of metal ions to biologically active agents may improve their efficiency and bioavailability and in some cases, reduce their well-recognized side effects [36] [37] [38] [39].…”

Section: Introductionmentioning

confidence: 99%

Syntheses, Characterization and Biological Activity of Novel Thiazoylazo Dye and Its Coordination Compounds

Aiyelabola¹

2021

ABC

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The present work describes the synthesis of a novel heterocyclic azo dye by general diazonization of 2-amino-4,5-dimethylthiazole followed by the diazocoupling of the resulting diazonium ion with 5-methyl-2-(propan-2-yl)phenol to obtain ligand L. This was characterized using Fourier-transformed infrared and electronic spectrophotometry. Ligand L was further coordinated with five metal ions, M:L, 1:2 [M = Cu(II), Mn(II), Zn(II), Ni(II) and Co(II)]. The coordination compounds obtained were characterized by electronic, IR spectrophotometry, magnetic susceptibility and percentage metal analyses. The results obtained suggested that a thiazoylazo dye was obtained as ligand L. It was proposed that two molecules of the solvent coordinated to the metal ion in addition with the ligands to give an octahedral geometry for copper(II), manganese(II) and nickel(II) complexes. On the other hand, square planar geometry was suggested for zinc(II) and cobalt(II) complexes. The anti-inflammatory activity of the ligand and coordination compounds was evaluated using four in vitro-based assays viz: xanthine oxidase and lipoxygenase inhibition assay, membrane stability and protein denaturation assay. The synthesized compounds generally exhibited good anti-inflammatory activity in all the assays carried out. However, the reference standards, in this instance, were more effective in the case of xanthine oxidase, lipoxygenase and protein denaturation inhibitory assays. For the membrane stability study, the coordination compounds and ligand L elicited more potent anti-inflammatory activity than the standard drug.

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Section: Introductionmentioning

confidence: 99%

Syntheses, Characterization and Biological Activity of Novel Thiazoylazo Dye and Its Coordination Compounds

Aiyelabola¹

2021

ABC

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“…Therefore, one present strategy in the field of pharmacological research is coordinating 1,10-phenanthroline with transition metal ions to make its nitrogen atoms unavailable for denaturation [ 12 – 15 ]. Furthermore, this activity enhances the medicinal activity of transition metal complexes [ 16 , 17 ]. Based on this, many transition metal complexes of 1,10-phenanthroline have been found exhibiting numerous biological activities such as antiviral [ 18 , 19 ], anti-inflammatory, antitumor [ 20 ], anti-Candida [ 21 ], antimycobacterial [ 22 ], and antimicrobial [ 23 ] activity upon binding to DNA.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of N-Tetradecyl-1,10-phenathrolinium-Based New Salts for Biological Applications

Abebe

Atlabachew

Liyew

et al. 2018

Bioinorganic Chemistry and Applications

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New organic salts were synthesized by quaternizing 1,10-phenanthroline using 1-bromotetradecane. The first step yielded an organic salt of formula [C26H37N2]Br. Anion exchange reaction using Li[(CF3SO2)2N] resulted in a more stable salt of formula [C26H37N2][(CF3SO2)2N]. The organic salts were investigated by spectrometry (1H, 13C, 19F NMR, X-ray photoelectron spectroscopy (XPS), UV-Vis, and matrix-assisted laser desorption/ionization mass spectroscopy (MALDI MS), CHNSBr elemental analysis, and thermal analysis (TGA and DSC). The thermal characterization showed the melting and decomposition points of [C26H37N2][(CF3SO2)2N] to be 48°C and 290°C, respectively, which indicates it is an ionic liquid with large liquidus range. The biological activities of the salts were investigated against two Gram-positive (Staphylococcus aureus and Streptococcus pyogenes) and two Gram-negative (Escherichia coli and Klebsiella pneumoniae) bacteria, and they are found to be active against all of them. They were compared with [Cu(1,10-phenanthroline)2Cl]Cl. They are found more active against the Gram-negative bacteria. The salts demonstrated minimum inhibitory concentration as low as 50 µg/L. These results suggest the synthesized salts can be considered as a better alternative to certain transition metal complex drugs. This minimizes the concern of introducing metal ions into the organism.

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“…This is because these compounds have shown significant potential in the production of therapeutic products. They are known for a variety of uses: physiological, antimicrobial 1,2 , antioxidant 3,5 , anti-inflammatory 6,7 , anticoagulant and antitumor 8 activities. In recent years, there is much attention in the search for antioxidants from natural, industrial sources.…”

Section: Introductionmentioning

confidence: 99%

Macro Coumarins as Novel Antioxidants

et al. 2018

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The present work pointed at the design and synthesis of novel coumarin compounds as antioxidants. The alteration of 4-hydroxycoumarin by several reaction levels was performed to generate destination compounds. Spectroscopic methods like Infrared Spectra FT-IR, 1H-NMR and 13CNMR, elemental analysis techniques, melting point, and thin layer chromatography defined the structure of the prepared compounds. The antioxidant activities of individual compounds were tested against stable free radical 1,1-Diphenyl-2-picrylhydrazyl radical (DPPH), hydrogen peroxide (H2O2) and FRAP (ferric reducing antioxidant power) and the results were related to the Gallic acid, ascorbic acid and Trolox as standards. The effects revealed that most of the syntheses presented greater activity as an antioxidant than the standards in different concentration range. The distinguished competence inactivating action was observed for compound 2 (86.3±1%) followed by compounds 3 (85±0.5%) using DPHH method. The antioxidant mode of action of the prepared compounds was also investigated.

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Synthesis Characterization and Biological Activities of Coordination Compounds of 4-Hydroxy-3-nitro-2H-chromen-2-one and Its Aminoethanoic Acid and Pyrrolidine-2-carboxylic Acid Mixed Ligand Complexes

Cited by 18 publications

References 52 publications

Syntheses, Characterization and Biological Activity of Novel Thiazoylazo Dye and Its Coordination Compounds

Syntheses, Characterization and Biological Activity of Novel Thiazoylazo Dye and Its Coordination Compounds

Synthesis of N-Tetradecyl-1,10-phenathrolinium-Based New Salts for Biological Applications

Macro Coumarins as Novel Antioxidants

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