Synthesis, Characterization and Biological Activities of Hydrazone Schiff Base and its Novel Metals Complexes

Hussain, İqbal; Ullah, Aaqib; Khan, Atta Ullah; Khan, Wali Ullah; Ullah, Riaz; Shahat, Abdelaaty A.; Mahmood, Hafiz Majid

doi:10.17576/jsm-2019-4807-13

Cited by 13 publications

(5 citation statements)

References 12 publications

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“…Another advantage of Au use in medicine is its low toxicity for humans [13]. The possibility of using gold(III) complexes for the treatment of bacterial, fungal infections, and malaria is much less studied (a review [14] still accumulates most of the known data on gold(III) complexes as antibiotics; see also papers [15][16][17][18][19][20]). However, the most recent paper by Ratia et al [21] shows the potential of gold(III) complexes in the most convincing manner.…”

Section: Introductionmentioning

confidence: 99%

Geometry and UV-Vis Spectra of Au3+ Complexes with Hydrazones Derived from Pyridoxal 5′-Phosphate: A DFT Study

Pimenov

Grazhdan

Завалишин

et al. 2023

IJMS

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Gold(III) complexes with different ligands can provide researchers with a measure against pathogenic microorganisms with antibiotic resistance. We reported in our previous paper that the UV-Vis spectra of different protonated species of complexes formed by gold(III) and five hydrazones derived from pyridoxal 5′-phosphate are similar to each other and to the spectra of free protonated hydrazones. The present paper focuses on the reasons of the noted similarity in electron absorption spectra. The geometry of different protonated species of complexes of gold(III) and hydrazones (15 structures in total) was optimized using the density functional theory (DFT). The coordination polyhedron of gold(III) bond critical points were further studied to identify the symmetry of the gold coordination sphere and the type of interactions that hold the complex together. The UV-Vis spectra were calculated using TD DFT methods. The molecular orbitals were analyzed to interpret the calculated spectra.

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Section: Introductionmentioning

confidence: 99%

Geometry and UV-Vis Spectra of Au3+ Complexes with Hydrazones Derived from Pyridoxal 5′-Phosphate: A DFT Study

Pimenov

Grazhdan

Завалишин

et al. 2023

IJMS

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“…In the IR spectrum of H 2 L, the C=O, C=N and NH vibrations were identified at 1729, 1692, 3336, and 3188 cm −1 , respectively. Vibrations in the range of 1713–1737, 1685, 3273, and 3193 cm −1 were reported for other compounds of isatin hydrazone derivatives with similar environment (Hussein et al 2019 ; Jabbar 2018 ). Additional spectral data are available in the supplementary data (Figs S7–S10).…”

Section: Resultsmentioning

confidence: 70%

5-chloro-3-(2-(2,4-dinitrophenyl) hydrazono)indolin-2-one: synthesis, characterization, biochemical and computational screening against SARS-CoV-2

Majoumo-Mbe,

Sangbong,

Tadjong Tcho

et al. 2024

Chem. Pap.

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Chemical prototypes with broad-spectrum antiviral activity are important toward developing new therapies that can act on both existing and emerging viruses. Binding of the SARS-CoV-2 spike protein to the host angiotensin-converting enzyme 2 (ACE2) receptor is required for cellular entry of SARS-CoV-2. Toward identifying new chemical leads that can disrupt this interaction, including in the presence of SARS-CoV-2 adaptive mutations found in variants like omicron that can circumvent vaccine, immune, and therapeutic antibody responses, we synthesized 5-chloro-3-(2-(2,4-dinitrophenyl)hydrazono)indolin-2-one (H2L) from the condensation reaction of 5-chloroisatin and 2,4-dinitrophenylhydrazine in good yield. H2L was characterised by elemental and spectral (IR, electronic, Mass) analyses. The NMR spectrum of H2L indicated a keto–enol tautomerism, with the keto form being more abundant in solution. H2L was found to selectively interfere with binding of the SARS-CoV-2 spike receptor-binding domain (RBD) to the host angiotensin-converting enzyme 2 receptor with a 50% inhibitory concentration (IC50) of 0.26 μM, compared to an unrelated PD-1/PD-L1 ligand–receptor-binding pair with an IC50 of 2.06 μM in vitro (Selectivity index = 7.9). Molecular docking studies revealed that the synthesized ligand preferentially binds within the ACE2 receptor-binding site in a region distinct from where spike mutations in SARS-CoV-2 variants occur. Consistent with these models, H2L was able to disrupt ACE2 interactions with the RBDs from beta, delta, lambda, and omicron variants with similar activities. These studies indicate that H2L-derived compounds are potential inhibitors of multiple SARS-CoV-2 variants, including those capable of circumventing vaccine and immune responses.

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“…The number of combinations that can be made is therefore very large and the attribution of absorption bands to specific transitions is usually derived from literature databases and pure component spectra (“fingerprint spectra”) . For instance, the π–π* transition of a Schiff base Ni complex is observed between 339 and 350 nm, whereas for the Au complex, the transition is found in the range of 291–331 nm. , On the other hand, for a Ru Schiff base complex, the π–π* transition lies at 203–223 nm, and the n-π* and d-d transitions lie in the 355–406 nm and 616–630 nm ranges, respectively. Replacing the ligand by tridentate pyridinediimine (pydim), shifts the transition bands to 278–318 nm, 425–449 nm, and 536–566 nm …”

Section: Research In Catalysis With In Situ Uv–vis–nir Spectroscopymentioning

confidence: 99%

“…276 For instance, the π−π* transition of a Schiff base Ni complex is observed between 339 and 350 nm, whereas for the Au complex, the transition is found in the range of 291−331 nm. 279,280 On the other hand, for a Ru Schiff base complex, the π−π* transition lies at 203−223 nm, and the n-π* and d-d transitions lie in the 355−406 nm and 616−630 nm ranges, respectively. Replacing the ligand by tridentate pyridinediimine (pydim), shifts the transition bands to 278−318 nm, 425−449 nm, and 536−566 nm.…”

Section: Homogeneous Thermal Catalysismentioning

confidence: 99%

In Situ UV–Vis–NIR Absorption Spectroscopy and Catalysis

Bols,

Ma,

Rammal

et al. 2024

Chem. Rev.

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This review highlights in situ UV–vis–NIR range absorption spectroscopy in catalysis. A variety of experimental techniques identifying reaction mechanisms, kinetics, and structural properties are discussed. Stopped flow techniques, use of laser pulses, and use of experimental perturbations are demonstrated for in situ studies of enzymatic, homogeneous, heterogeneous, and photocatalysis. They access different time scales and are applicable to different reaction systems and catalyst types. In photocatalysis, femto- and nanosecond resolved measurements through transient absorption are discussed for tracking excited states. UV–vis–NIR absorption spectroscopies for structural characterization are demonstrated especially for Cu and Fe exchanged zeolites and metalloenzymes. This requires combining different spectroscopies. Combining magnetic circular dichroism and resonance Raman spectroscopy is especially powerful. A multitude of phenomena can be tracked on transition metal catalysts on various supports, including changes in oxidation state, adsorptions, reactions, support interactions, surface plasmon resonances, and band gaps. Measurements of oxidation states, oxygen vacancies, and band gaps are shown on heterogeneous catalysts, especially for electrocatalysis. UV–vis–NIR absorption is burdened by broad absorption bands. Advanced analysis techniques enable the tracking of coking reactions on acid zeolites despite convoluted spectra. The value of UV–vis–NIR absorption spectroscopy to catalyst characterization and mechanistic investigation is clear but could be expanded.

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Synthesis, Characterization and Biological Activities of Hydrazone Schiff Base and its Novel Metals Complexes

Cited by 13 publications

References 12 publications

Geometry and UV-Vis Spectra of Au3+ Complexes with Hydrazones Derived from Pyridoxal 5′-Phosphate: A DFT Study

Geometry and UV-Vis Spectra of Au3+ Complexes with Hydrazones Derived from Pyridoxal 5′-Phosphate: A DFT Study

5-chloro-3-(2-(2,4-dinitrophenyl) hydrazono)indolin-2-one: synthesis, characterization, biochemical and computational screening against SARS-CoV-2

In Situ UV–Vis–NIR Absorption Spectroscopy and Catalysis

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