Synthesis, Characterization and Biological Activity of DimethyltinDicarboxylates Containing Germanium

Choudhary, Muhammad Aziz; Mazhar, Muhammad; Ali, Syed Danish; Song, Xueqing; Eng, George

doi:10.1155/mbd.2002.275

Cited by 23 publications

(31 citation statements)

References 10 publications

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“…The isomer shifts and line widths of the complexes are typical of single tin(IV) site. 40 A comparison between the quadrupole splitting data for organotin(IV) derivatives and those reported in the literature for analogous compounds, 41 leads to the conclusion that, diorganotin(IV) complexes show hexa-coordination, 42 while the triorganotin(IV) adducts show penta-coordination. 43 Biological studies Antibacterial activity.…”

Section: Sn Mössbauer Spectramentioning

confidence: 91%

Comparative study of structure: activity relationship of di and triorganotin (IV) complexes of monomethyl glutarate

Rehman¹,

Baloch²,

Badshah³

2005

J. Braz. Chem. Soc.

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Uma série de complexos di-e tri-organoestanho(IV) de metilglutarato foram sintetizados e caracterizados por espectroscopia de RMN de 1 H, 13 C e 119 Sn, no infravermelho e Mössbauer de 119 Sn. Baseado nestas técnicas propõe-se que o ligante se encontra ligado ao estanho através do oxigênio da carbonila. Os dados revelam também que os complexos diorganoestanho(IV) são hexacoordenados, com geometria octaedrica, enquanto que os complexos triorganoestanho(IV) são pentacoordenados e possuem geometria bipiramidal trigonal. A avaliação biológica contra vários microorganismos indica que os complexos diorganoestanho(IV) são menos ativos que os triorganoestanho(IV).A series of di and triorganotin(IV) complexes of monomethyl glutarate have been synthesized and characterized through 1 H 13 C 119 Sn NMR, FT-IR and 119 Sn Mössbauer spectroscopy. On the basis of these techniques, it is proposed that the ligand molecule is bound to the tin atom through the carbonyl oxygen. The data reveal that diorganotin(IV) complexes exhibit hexa-coordination with octahedral geometry, while triorganotin(IV) complexes have penta-coordination with trigonal bipyramidal geometry. Biological evaluation against various microorganisms indicate that diorganotin(IV) complexes are less active than the triorganotin(IV) complexes.Keywords: organotin(IV), monomethyl glutarate, biological activity IntroductionOrganotin(IV) complexes have wide applications as catalysts, stabilizers as biocides, as antifouling agents, and for wood preservers. [1][2][3][4][5][6][7][8][9][10] In recent years, investigations have been carried out to test their antitumor activity, and it has been observed that indeed several di and triorganotin(IV) species were found to be active against various types of cancer. 11-13. Biological activity of organotin complexes is believed to be independent on the structure of molecule and coordination number of the metal. [4][5][6] It has also been noted that many di and triorganotin(IV) carboxylates display interesting anti tumor activities. [13][14][15][16][17][18][19][20] However the solubility of di and tri-organotin(IV) carboxylates in water and water-ethanol is poor, therefore many organotin(IV) complexes with carboxylate ligands containing polar subsitituents (hydroxo and oxo groups) have been prepared and studied. [13][14][15][16][17][18][19][20] In a previous paper we described the synthesis of organotin(IV) complexes of maleimidoacetic acid. 21 In the present work we report the synthesis, spectroscopic characterization, antibacterial and various biological activities of a series of di and triorganotin(IV) complexes of monomethyl glutarate. ExperimentalAll the di and triorganotin(IV) compounds except for dibenzyl and tribenzyl tin chlorides were purchased from Fluka and were used as such. Di and tribenzyltin chlorides were synthesized from the literature method. 22 All the reactions were carried out under anhydrous and oxygen free nitrogen atmosphere. The solvents used were dried before use according to the literature method. 23 The...

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Section: Sn Mössbauer Spectramentioning

confidence: 91%

Comparative study of structure: activity relationship of di and triorganotin (IV) complexes of monomethyl glutarate

Rehman¹,

Baloch²,

Badshah³

2005

J. Braz. Chem. Soc.

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“…Some of these compounds were found to be more active for certain bacteria, such as Bacillus cerus and Klebsiella pneumoniae, than the reference drugs were. 7 In a continuation of our previous reports, 8,9 we have synthesized some triorganotin carboxylates containing triorganogermyl groups as part of the carboxylate ligands and report their structures, antibacterial, antifungal and lethality bioassays.…”

Section: Introductionmentioning

confidence: 89%

Some tricyclohexyltin carboxylates containing germanium: synthesis, spectral and crystallographic characterization

Imtiaz‐ud‐Din

Molloy

Mazhar

et al. 2003

Applied Organom Chemis

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“…Several new band appearing in the complexes at ∼460, ∼545, ∼660, ∼460, and ∼540 cm −1 are probably due to ν(Sn-O) [15,24], ν(Sn←N) [15,25], ν(Sn-C) [15,26], ν(Pb-O) [13,27], and ν(Pb←N) [13,27], respectively.…”

Section: Resultsmentioning

confidence: 95%

Synthesis and Characterization of New Lead(II) and Organotin(IV) Complexes of Schiff Bases Derived from Histidine and Methionine

Singh

2012

International Journal of Inorganic Chemistry

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New Schiff base (HL) ligand is prepared via condensation of isatins and amino acids in 1:1 molar ratio. Metal complexes are prepared and characterized by elemental analysis, molar conductance, electronic, infrared, and multinuclear magnetic resonance ( 1 H NMR, 13 C NMR, and 119 Sn NMR). The analytical data showed that the ligand acts as bidentate toward metal ions via azomethine nitrogen and carboxylate oxygen by a stoichiometric reaction of metal : ligand (1 : 2) to from metal complexes (Pb(II)(L) 2 and Bu 2 Sn(L) 2 , where L is the Schiff base ligands of histidine and methionine). The conductivity values between 15 and 25 Ω −1 cm 2 mol −1 in DMF imply the presence of nonelectrolyte species. On the basis of the above spectral studies, distorted octahedral and tetrahedral geometry have been proposed for the resulting organotin(IV) and lead(II) complexes.

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Synthesis, Characterization and Biological Activity of DimethyltinDicarboxylates Containing Germanium

Cited by 23 publications

References 10 publications

Comparative study of structure: activity relationship of di and triorganotin (IV) complexes of monomethyl glutarate

Comparative study of structure: activity relationship of di and triorganotin (IV) complexes of monomethyl glutarate

Some tricyclohexyltin carboxylates containing germanium: synthesis, spectral and crystallographic characterization

Synthesis and Characterization of New Lead(II) and Organotin(IV) Complexes of Schiff Bases Derived from Histidine and Methionine

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