Synthesis, Characterization and Biological Activity of Mixed Ligand (Imine of Benzidine and 1,10-Phenanthroline) Complexes with Fe(II), Co(II), Ni(II) and Cu(II) Ions

Abstract

In this paper, binuclear metal complexes of the metal ions Fe(II), Co(II), Ni(II) and Cu(II) were synthesized by the reaction of the primary ligand (imine of benzidine) (H2L) and the secondary ligand (1,10-phenanthroline) (L`) with these metal ions in a molar ratio of 1:2:2, respectively. The complexes were characterized using CHN elemental analysis, FT-IR, UV-Vis, magnetic susceptibility, molar conductivity, 1H NMR, and TGA-DTA thermogravimetric analysis. According to the results obtained from the elemental analysis and spectral measurements where complexes of Fe(II), Co(II) and Ni(II) have octahedral geometry, while the complex with Cu(II) has a square planar geometry. All the prepared complexes are wholly stable and can keep for months without any significant change. The antibacterial activities of the prepared compounds were evaluated with regard to two bacteria species, gram-negative Proteus and Kelbsiella, by using diffusion agar plates. The inhibition zone diameter around the holes indicated the sensitivity of the bacteria to these compounds, where the Klebsiella bacteria were revealed to be more highly sensitive to these compounds than Proteus bacteria. All synthesized complexes showed more significant effects against Kelbsiella and Protea than the antibiotic (Amikacin).

Synthesis, Characterization and Antibacterial Activity of Sn(II) and Sn(IV) Ions Complexes Containing N-Alkyl-N-Phenyl Dithiocarbamate Ligands

“…The peaks were observed at 251 nm, which corresponds to the electronic transmission (π→π*) in pi system in a benzene ring and N-C=S systems, and at 321 nm, which corresponds to the electronic transmission (n→π*) in nitrogen and sulfur sys-tems (n→π*). [27][28][29][30] The electronic spectra of complexes (C1L1) and (C2L1), showed the same bands at 294 nm, 364 nm, 492 nm (Figs. [16][17], but the difference is in the strength of the bands.…”

“…The results of (Figs. [23][24][25][26][27][28] show that the pH λ max for the L1 and L2 was at pH=9, whereas the λ max of their complexes was at pH=2 for (C1L1) and (C3L2), and at pH=4 for (C2L1) and (C4L2). Job's method was adopted for continuous changes in order to determine the positional formula of the complexes.…”

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“…The 1 HNMR spectrum of the ligands showed the hydroxyl protons appeared at δ = 3.23 ppm for water. The chemical shifts of the DMSO appeared in 2.45-2.53 ppm [35,36].…”

New Series of Ni(II), Cu(II), Zr(IV), Ag(I), and Cd(II) Complexes of Trimethoprim and Diamine Ligands: Synthesis, Characterization, and Biological Studies

“…Due to its composition of N and O atoms, trimethoprim acts as a multi-dentate ligand, forming comprehensive compounds with metal ions [5]. In combination with other ligands like bipy and 1,10-phen, it forms mixed ligands that demonstrate stability in biological, organic, and thermal contexts [6]. Notably, there's potential for antitumor cytotoxicity [7].…”