Synthesis, characterization and biological activity of 2-acetylpyridine-α-naphthoxyacetylhydrazone its metal complexes

El‐Gammal, O.A.; Bekheit, M. M.; Tahoon, Mai

doi:10.1016/j.saa.2014.05.071

Cited by 21 publications

(12 citation statements)

References 42 publications

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“…The g iso (2.04) value less than 2.3 indicates the covalent character of the metal ligand bond and the α 2 value (1.87) suggestive of in‐plane covalency. The calculated value (g || /A || ) 124 cm −1 for the complex is consistent with slightly distorted structure and showed poor in‐plane π bonding …”

Section: Resultssupporting

confidence: 66%

Azo dye with nitrogen donor sets of atoms and its metal complexes: Synthesis, characterization, DFT, biological, anticancer and Molecular docking studies

Mahmoud

Sayed

2018

Applied Organom Chemis

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An azo derivative was synthesized by coupling diazotized 2,6-diaminopyridine with p-dimethyl amino benzaldehyde and this new ligand formed a series of metal complexes with Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) salts. These complexes were characterized on the basis of elemental analyses, molar conductance, infrared spectroscopy, UV-Vis, 1 H NMR, mass spectrometry, electronic spectra, magnetic susceptibility and ESR spectral studies, conductivity measurements, thermogravimetric analyses (TG-DTG). The molecular and electronic structure of the azo ligand was optimized theoretically and the quantum chemical parameters were calculated. The ligand and its metal complexes were subjected to X-ray powder diffraction study. The thermal stability of the ligand and its metal complexes was examined by thermogravimetry. The ligand and its complexes were tested for their in vitro antimicrobial activity, some of the complexes showed good antimicrobial activities against some selected bacterial and fungal strains. Anticancer activity of the ligand and its metal complexes are evaluated against human cancer (MCF-7 cells viability). Molecular docking was used to predict the binding between azo ligand and the receptors of nucleoside diphosphate kinase of Staphylococcus aureus (3Q8U) and (3HB5) which is breast cancer mutant oxidoreductase. The docking study provided useful structural information for inhibition studies.

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Section: Resultssupporting

confidence: 66%

Azo dye with nitrogen donor sets of atoms and its metal complexes: Synthesis, characterization, DFT, biological, anticancer and Molecular docking studies

Mahmoud

Sayed

2018

Applied Organom Chemis

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“…Furthermore, triazole complexes showed very good antimicrobial [ 15 ] and antitumor [ 16 ] activities. The combination of metals and azoles is a promising strategy to develop new efficient drugs, even against drug-resistant pathogens [ 17 , 18 , 19 , 20 , 21 , 22 ]. The development of these new drugs is related to the complexation of azole derivatives with transition metals that have low toxicity and are biocompatible [ 18 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…In line with our results, Sumrra et al recently reported that complexes derived from triazole had antibacterial and antifungal activities higher than the corresponding ligands [ 28 ]. Two well-known theories have been presented to explain the increase in the activity in the complexes with respect to the free ligands (the overtone’s concept [ 17 ] and Tweedy’s chelation theory [ 29 ]). The coordination of triazoles to metal centers could be an interesting approach for achieving antibacterial and antifungal activities with lower concentrations of the complexes.…”

Section: Introductionmentioning

confidence: 99%

Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes: Synthesis and Biological Activity Evaluations

et al. 2018

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In this work, six complexes (2–7) of Cr(III) and Co(II) transition metals with triazole ligands were synthesized and characterized. In addition, a new ligand, 3,5-bis(1,2,4-triazol-1-ylmethyl)toluene (1), was synthesized and full characterized. The complexes were obtained as air-stable solids and characterized by melting point, electrical conductivity, thermogravimetric analysis, and Raman, infrared and ultraviolet/visible spectroscopy. The analyses and spectral data showed that complexes 3–7 had 1:1 (M:L) stoichiometries and octahedral geometries, while 2 had a 1:2 (M:L) ratio, which was supported by DFT calculations. The complexes and their respective ligands were evaluated against bacterial and fungal strains with clinical relevance. All the complexes showed higher antibacterial and antifungal activities than the free ligands. The complexes were more active against fungi than against bacteria. The activities of the chromium complexes against Candida tropicalis are of great interest, as they showed minimum inhibitory concentration 50 (MIC50) values between 7.8 and 15.6 μg mL−1. Complexes 5 and 6 showed little effect on Vero cells, indicating that they are not cytotoxic. These results can provide an important platform for the design of new compounds with antibacterial and antifungal activities.

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“…The 1 H NMR spectrum of the H 6 EPH derivative in d 6 -DMSO ( Fig. 2a) reveals signals at δ: 10.02, 9.29 and 9.26 ppm may be referred to N 4 H, N 2 H and N 1 H protons, respectively [28]. These signals diminished on the addition of D 2 O.…”

Section: Nmr Spectramentioning

confidence: 97%

Binuclear metal complexes of a symmetric polydentate donor hydrazone: synthesis, spectral characterization, DNP DFT computational and biological studies

2019

Biointerface Res Appl Chem

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Co(II), Ni(II)and Cu(II) complexes of a new chelate namely 2,2'-((9S,10S,11R,12R)-9,10-dihydro-9,10-ethanoanthracene-11,12-dicarbonyl)bis(N-phenylhydrazine-1-carboxamide) (H6EPH) were synthesized and were characterized by using analytical and spectral techniques suggesting tetrahedral geometry for Ni(II) and Cu(II) complexes and an octahedral for Co(II) complex. The ESR spectral data showed one broad band with g|| > 2.0036 indicating the axial symmetry with the unpaired electron residing in the dx2-y2 orbital with appreciable covalent character of the metal-ligand bond. The molecular modeling a using DFT method was drawn and the bond lengths, bond angles, chemical reactivity and energy components (kcal/mol) for all the title compounds were evaluated. Also, all compounds were examined for DNA cleavage ability and antioxidant using superoxide dismutase like- activity.

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Synthesis, characterization and biological activity of 2-acetylpyridine-α-naphthoxyacetylhydrazone its metal complexes

Cited by 21 publications

References 42 publications

Azo dye with nitrogen donor sets of atoms and its metal complexes: Synthesis, characterization, DFT, biological, anticancer and Molecular docking studies

Azo dye with nitrogen donor sets of atoms and its metal complexes: Synthesis, characterization, DFT, biological, anticancer and Molecular docking studies

Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes: Synthesis and Biological Activity Evaluations

Binuclear metal complexes of a symmetric polydentate donor hydrazone: synthesis, spectral characterization, DNP DFT computational and biological studies

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