Synthesis, characterization and biological activity in vitro of FeCrAl(f)/HA asymmetrical biological functionally gradient materials

Yang, Hailin; Li, Jing; Fang, Huajing; Zhou, Zhiyong; Tong, Xiao-yang; Ruan, Jianming

doi:10.1007/s11771-014-1958-8

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…The n-HA powder was prepared by chemical precipitation using diammonium phosphate, calcium nitrate and ammonia (Shenzhen Heaven) as the raw materials. According to the chemical formula [8] 2 O, the n-HA powder was milled for 24 hours in a ceramic jar after the white sedimentation cake had dried. The n-HA powder was calcined at 850°C for 1 hour to increase degree of crystallinity.…”

Section: Preparation Of Poly-l-lactic Acid and N-hamentioning

confidence: 99%

Evaluation of the novel three-dimensional porous poly (L-lactic acid)/nano-hydroxyapatite composite scaffold

Huang

Xiong

Liu

et al. 2015

BME

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Abstract.To determine the optimal ratio of nano-hydroxyapatite (n-HA) to polylactic acid (PLLA) in the novel three-dimensional porous PLLA/n-HA composite scaffolds, low-temperature rapid prototyping technology was employed to fabricate the composite materials with different n-HA contents. Mechanical properties and degradation behaviors of the composites were examined, and the scaffold microstructure and n-HA dispersion were observed by scanning electron microscope (SEM). Mechanical tests demonstrated that the tensile strength of the composite material gradually decreased with an increase in n-HA content. When the n-HA content reached 20 wt%, the bending strength of the composite material peaked at 138.5 MPa. SEM images demonstrated that the optimal content of n-HA was 20 wt% as the largest interconnected pore size that can be seen, with a porosity as high as 80%. In vitro degradation experiments demonstrated that the pH value of the material containing solution gradually decreased in a time-dependent manner, with a simultaneous weakening of the mechanical properties. In vitro study using rat osteoblast cells showed that the composite scaffolds were biocompatible; the 20 wt% n-HA scaffold offered particular improvement to rat osteoblast cell adhesion and proliferation compared to other compositions. It was therefore concluded that 20 wt% n-HA is the optimal nano-hydroxyapatite (n-HA) to polylactic acid (PLLA) ratio, with promise for bone tissue engineering.

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Section: Preparation Of Poly-l-lactic Acid and N-hamentioning

confidence: 99%