Synthesis, characterization and biological evaluation of some pyridine and quinoline fused chromenone derivatives

Patel, Mohan N.; Bhila, Varun G.; Patel, Niraj H.; Patel, Anil Kumar; Brahmbhatt, D. I.

doi:10.1007/s00044-012-9978-0

Cited by 32 publications

(21 citation statements)

References 19 publications

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“…Agar-diffusion method (Sridhar et al, 2004;Patel et al, 2012) was used for the determination of the preliminary antibacterial and antifungal activity. Ciprofloxacin and itrazole were used as reference drugs for antibacterial and antifungal activity, respectively.…”

Section: Antimicrobial Evaluationmentioning

confidence: 99%

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Synthesis, characterization and molecular docking studies of novel 2-amino 3-cyano pyrano[2,3H]chrysin derivatives as potential antimicrobial agents

et al. 2015

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A series of novel 2-amino 3-cyano 4-aryl pyrano[2,3H]chrysin derivatives (3a-m) were efficiently synthesized by one-pot three-component reaction of aromatic aldehydes, malononitrile and chrysin and characterized by 1 H NMR, 13 C NMR and mass spectral data. All the newly synthesized compounds were evaluated for their in vitro antimicrobial activity (antibacterial and antifungal). Among the tested compounds, 3a, 3g, 3h, 3j and 3k showed potent antibacterial activity compared to ciprofloxacin and the compounds 3a, 3g, 3h, 3i and 3k showed excellent antifungal activity compared to itrazole. The compounds 3a, 3g, 3h and 3k exhibited potent antimicrobial activity against all the selected pathogenic bacteria and fungi and emerged as potential molecules for further development. In addition, molecular modeling studies also performed to delineate the putative binding mode of these compounds. All of these chrysin derivatives (3a-m) obeyed the Lipinski's ''rule of five'' and have drug-likeness. Docking scores with appreciable binding energy values also exactly correlated with the experimental antimicrobial activity. The chemscore estimated by GOLD software was found to have a good correlation with the experimental inhibitory activity. Graphical Abstract Docking of compound 3g with protein A series of novel 2-amino 3-cyano pyrano[2,3H]chrysin derivatives (3a-m) has been synthesized and evaluated for their antimicrobial activity along with molecular modeling studies

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Section: Antimicrobial Evaluationmentioning

confidence: 99%

“…The plates were incubated at 37°C for 1-3 days. Antimicrobial activity was determined by measuring the diameter of the zone of inhibition surrounding microbial growth (Sridhar et al, 2004;Patel et al, 2012). Compounds that showed significant growth inhibition zones were further evaluated for their MICs.…”

Section: Biological Assaysmentioning

confidence: 99%

Synthesis, characterization and molecular docking studies of novel 2-amino 3-cyano pyrano[2,3H]chrysin derivatives as potential antimicrobial agents

et al. 2015

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“…The plates were incubated at 35°C for 1–2 days. Antibacterial activity was determined by measuring the diameter of the zone of inhibition surrounding microbial growth .…”

Section: Methodsmentioning

confidence: 99%

Synthesis of Isoxazole, 1, 2, 4‐Oxadiazole and (1H‐Pyrazol‐4‐yl)‐methanone Oxime Derivatives from N‐Hydroxy‐1H‐pyrazole‐4‐carbimidoyl Chloride and their Biological Activity

Bhavanarushi

Gandu

Anupoju

et al. 2015

Journal of Heterocyclic Chem

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“…[34,35] For this study, standard sterilized filter paper disks (5 mm diameter) had been impregnated with a solution of dimethyl sulfoxide (1 mg/mL) containing the test compound, and placed in agar plate seeded with the suitable test organism in triplicate.…”

Section: Antimicrobial Assaymentioning

confidence: 99%

“…For comparative evaluation, ciprofloxacin was used as standard antibacterial drug and nystatin was used as standard antifungal drug. [34,35]…”

Section: Antimicrobial Assaymentioning

confidence: 99%

F(1H‐Pyrazol‐4‐yl)methylene‐Hydrazide derivatives: Synthesis and antimicrobial activity

Bhavanarushi

Luo

Gandu

et al. 2019

Journal of Heterocyclic Chem

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This paper investigates the seismic and collapse performance of shape memory alloy (SMA) braced steel frame structures considering the effects of various brace design parameters and ultimate state of SMAs. An SMA braced steel frame building is designed to have comparable strength and stiffness with a steel-moment resisting frame selected as case study building. Then, the stiffness and ultimate deformation capacity of the SMA braces in the initially designed reference SMA braced frame are systematically varied. First, the static pushover analysis and incremental dynamic analysis (IDA) are employed to illustrate the significance of SMA brace failure consideration in seismic performance assessment of steel frames with SMA elements. Then, the influence of SMA brace initial stiffness and ultimate deformation capacity on the seismic and collapse performance of SMA braced frames are studied through pushover analyses, nonlinear response history analyses, and IDA. The results show that the SMA brace initial stiffness does not affect the interstory drift and floor absolute acceleration response at design and maximum considered earthquake (MCE) level seismic hazard or collapse capacity of the frame. However, it has considerable influence on post-event functionality of the frame. It is also found that the SMA brace ultimate deformation capacity should be at least 80% of maximum inter-story drift demand at MCE level for satisfactory seismic performance, while larger values provide higher collapse capacity for the SMA braced frame.

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Synthesis, characterization and biological evaluation of some pyridine and quinoline fused chromenone derivatives

Cited by 32 publications

References 19 publications

Synthesis, characterization and molecular docking studies of novel 2-amino 3-cyano pyrano[2,3H]chrysin derivatives as potential antimicrobial agents

Synthesis, characterization and molecular docking studies of novel 2-amino 3-cyano pyrano[2,3H]chrysin derivatives as potential antimicrobial agents

Synthesis of Isoxazole, 1, 2, 4‐Oxadiazole and (1H‐Pyrazol‐4‐yl)‐methanone Oxime Derivatives from N‐Hydroxy‐1H‐pyrazole‐4‐carbimidoyl Chloride and their Biological Activity

F(1H‐Pyrazol‐4‐yl)methylene‐Hydrazide derivatives: Synthesis and antimicrobial activity

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