Synthesis, characterization and biological evaluation of 7-substituted- 4-((1-aryl-1H-1,2,3-triazol-4-yl) methyl)-2H-benzo[b][1,4]oxazin- 3(4H)-ones as anticancer agents

Microwave-assisted synthesis, molecular docking studies of 1,2,3-triazole-based carbazole derivatives as antimicrobial, antioxidant and anticancer agents

“…Some of the known indole-containing triazole-based moieties have been found to exhibit wide variety of biological activities such as antibacterial, 14 antioxidant, 15 anticancer, [16][17][18] and antitubercular 19 (Fig. 1).…”

Photoredox catalysis leading to triazolo-quinoxalinones at room temperature: selectivity of the rate determining step

“…[1][2][3][4][5][6][7][8] Most importantly, they also constitute the core of relevant bioactive molecules that have been used as drugs since they show a variety of pharmacological activities such as antibacterial, antifungal, anti-HIV or cardiovascular. [9][10][11][12] A lot of methodologies have been developed to grant access to these scaffolds. [13][14][15] Among them, the most efficient synthetic approach to prepare the 1,2,3-triazole core, and also 1,2,3-triazole ring fused heterocycles, is the Huisgen cycloaddition or click chemistry.…”

Design, Synthesis, and Bioactivity of Eighteen Novel 2H‐1,4‐Benzoxazin‐3(4H)‐one Containing a Propanolamine Moiety

“…[8,9] The biological activity of heterocyclic compounds is an important focus in the exploration of new inhibitory backbone templates. Considerable research has been carried out on 2H-1,4-benzoxazin-3(4H)-one in the medical field, while related pesticides have exhibited antifungal, [10,11] antibacterial, [12 -14] herbicidal, [15,16] anticancer, [17,18] antitumor, [19] antileukaemia, [20] antagonist, [21] antioxidant, [22] and platelet aggregation inhibitor activities [23] (Figure 1). Moreover, many reports demonstrate that compounds containing propanolamine moiety have wide-ranging biological activities, including antifungal, [24] antibacterial, [25,26] anti-HIV, [27] anticancer [28] and antihypertensive [29] properties.…”