Synthesis, characterization, and biological properties of composites of hydroxyapatite and hexagonal boron nitride

Unal, Semra; Ekren, Nazmi; Şengil, A. Zeki; Oktar, Faik N.; Irmak, Ster; Oral, Özlem; Şahin, Yeşim Müge; Kılıç, Osman; Agathopoulos, Simeon; Gündüz, Oğuzhan

doi:10.1002/jbm.b.34046

Cited by 20 publications

(3 citation statements)

References 24 publications

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“…The selection of 1.5, 3, 4.5, and 6 wt% hBN as specific proportions was based on a careful consideration of the literature [31][32][33] and preliminary experiments. Extensive research and prior studies [34][35][36] have shown that varying the wt% of hBN within these ranges can significantly influence the properties of the resulting composite. Lower concentrations like 1.5 wt% were chosen to observe if even a small addition of hBN could impart noticeable enhancements.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of ADC-12 hybrid composites utilizing lemon grass ash and boron nitride through stir-squeeze casting method

Palanivendhan,

Chandradass

2023

Mater. Res. Express

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In recent years, there has been increased interest in hybridizing metal matrix composites using agro-based-waste materials as sustainable choices. Despite the poor tribo-mechanical properties of conventional reinforcement materials, there is immense potential for using alternate reinforcing elements to enhance the mechanical features of matrix composite. In addition, conventional casting procedures present several challenges, including high costs and a lack of adequate mechanical qualities in the finished product. To combat these issues, the authors herein produce the well-known aluminium matrix composite (AMC), ADC 12 alloy, using waste Malabar lemon grass (MLG) ash at a fixed rate (6 wt%) and hexagonal Boron Nitride (hBN) at variable proportions (0, 1.5, 3, 4.5, and 6 wt%) as reinforcing element against traditional reinforcement particles to enhance the tribo-mechanical properties of casted hybrid AMC. In addition, the squeeze casting method produces the hybrid AMC, dramatically decreasing production costs and enhancing final product qualities. The hybrid AMC formed by squeeze casting is examined for its mechanical, corrosion, and tribological characteristics, with the findings indicating that the addition of MLG and hBN improved the mechanical, corrosion, and tribological properties of the ADC-MLG-hBN composites, with 6wt% MLG and 4.5wt% hBN reinforcements producing the optimal result. The experimental density of ADC-MLG- hBN composites was reduced by 8% when compared to the ADC 12 alloy, while the composites' tensile, hardness, and compressive strength were increased by 118.9%, 36.7%, and 33.6%, respectively. Similarly, the developed composite showed an improved corrosion resistance of 43.8% for 24 hours, and the wear rate decreased by 90.4%.

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Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of ADC-12 hybrid composites utilizing lemon grass ash and boron nitride through stir-squeeze casting method

Palanivendhan,

Chandradass

2023

Mater. Res. Express

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“…Similarly, CeO 2 -CdO nanocomposites also had antimicrobial activity against Gram-negative bacteria (Magdalane et al, 2017). Furthermore, nanocomposite Mn and Fe ion-doped ZnO NPs have been observed to have higher antibacterial activity against a wide range of bacteria such as S. aureus, Bacillus subtilis, Proteus mirabilis, and E. coli compared with ZnO (Unal et al, 2018;Bahari et al, 2019). It was also seen that nanocomposites with metal oxides significantly improve the antimicrobial action through some external factor induction (Hsueh, 2010).…”

Section: Nanocomposites Targeting Gram-positive Bacterial Biofilmmentioning

confidence: 91%

The role of nanocomposites against biofilm infections in humans

Varma¹,

Warghane

Dhiman

et al. 2023

Front. Cell. Infect. Microbiol.

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The use of nanomaterials in several fields of science has undergone a revolution in the last few decades. It has been reported by the National Institutes of Health (NIH) that 65% and 80% of infections are accountable for at least 65% of human bacterial infections. One of their important applications in healthcare is the use of nanoparticles (NPs) to eradicate free-floating bacteria and those that form biofilms. A nanocomposite (NC) is a multiphase stable fabric with one or three dimensions that are much smaller than 100 nm, or systems with nanoscale repeat distances between the unique phases that make up the material. Using NC materials to get rid of germs is a more sophisticated and effective technique to destroy bacterial biofilms. These biofilms are refractory to standard antibiotics, mainly to chronic infections and non-healing wounds. Materials like graphene and chitosan can be utilized to make several forms of NCs, in addition to different metal oxides. The ability of NCs to address the issue of bacterial resistance is its main advantage over antibiotics. This review highlights the synthesis, characterization, and mechanism through which NCs disrupt Gram-positive and Gram-negative bacterial biofilms, and their relative benefits and drawbacks. There is an urgent need to develop materials like NCs with a larger spectrum of action due to the rising prevalence of human bacterial diseases that are multidrug-resistant and form biofilms.

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“…Besides the polymeric ones, various formulations of non-polymeric nanoparticles (silica-based, metallic) have also been used as nano-delivery systems for bone regeneration. For example, calcium phosphate-based non-polymeric nanoparticles are mostly used due to their similarities to human bone [241][242][243]. Delivering several growth factors is one of the nanoparticle-based therapeutic strategies based on the stimulation of osteoblasts for bone formation [244][245][246][247].…”

Section: Regenerative Therapymentioning

confidence: 99%

Therapeutic Nanoparticles and Their Targeted Delivery Applications

et al. 2020

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Nanotechnology offers many advantages in various fields of science. In this regard, nanoparticles are the essential building blocks of nanotechnology. Recent advances in nanotechnology have proven that nanoparticles acquire a great potential in medical applications. Formation of stable interactions with ligands, variability in size and shape, high carrier capacity, and convenience of binding of both hydrophilic and hydrophobic substances make nanoparticles favorable platforms for the target-specific and controlled delivery of micro- and macromolecules in disease therapy. Nanoparticles combined with the therapeutic agents overcome problems associated with conventional therapy; however, some issues like side effects and toxicity are still debated and should be well concerned before their utilization in biological systems. It is therefore important to understand the specific properties of therapeutic nanoparticles and their delivery strategies. Here, we provide an overview on the unique features of nanoparticles in the biological systems. We emphasize on the type of clinically used nanoparticles and their specificity for therapeutic applications, as well as on their current delivery strategies for specific diseases such as cancer, infectious, autoimmune, cardiovascular, neurodegenerative, ocular, and pulmonary diseases. Understanding of the characteristics of nanoparticles and their interactions with the biological environment will enable us to establish novel strategies for the treatment, prevention, and diagnosis in many diseases, particularly untreatable ones.

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Synthesis, characterization, and biological properties of composites of hydroxyapatite and hexagonal boron nitride

Cited by 20 publications

References 24 publications

Fabrication and characterization of ADC-12 hybrid composites utilizing lemon grass ash and boron nitride through stir-squeeze casting method

Fabrication and characterization of ADC-12 hybrid composites utilizing lemon grass ash and boron nitride through stir-squeeze casting method

The role of nanocomposites against biofilm infections in humans

Therapeutic Nanoparticles and Their Targeted Delivery Applications

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