Synthesis, Characterization and Biological Screening of Novel Imidazolylpyrazole Scaffolds

Abstract

A novel series of 3-(4-aryl)-4-(4,5-diphenyl-1H-imidazol-2-yl)-1-phenyl-1H-pyrazole was synthesized by employing the well-known Debus-Radziszewski reaction. Structures of all the newly synthesized compounds have been characterized by various spectroscopic techniques viz. FTIR, 1H and 13C NMR, LC-MS and elemental analysis. All these compounds were also screened for antimicrobial potential against bacterial strains of S. aureus, K. pneumoniae and fungal strains of A. niger and T. rubrum.

Synthesis, In Silico Study, and In Vitro Antifungal Activity of New 5-(1,3-Diphenyl-1H-Pyrazol-4-yl)-4-Tosyl-4,5-Dihydrooxazoles

“…The characteristic signals of the H4 and H5 protons of the dihydrooxazole ring were found between 5. 79 a Reactions of entries 1-10 were performed with 1.0 equiv mol of 4, 1.8 equiv mol of TosMIC 5, and 2.5 equiv mol of K 2 CO 3 in THF at rt for 3 h. b Reactions of entries 11-20 were performed with 1.0 equiv mol of 4, 1.2 equiv mol of TosMIC 5, and 1.2 equiv mol of KOH in MeOH at rt for 3 h. c Isolated yield after column chromatography.…”

“…mdpi.com/article/10.3390/ijms25105091/s1. References [76][77][78][79][80][81][82][83][84] are cited in the Supplementary Materials.…”