Synthesis, characterization and biological studies of diorganotin(IV) complexes with tris[(hydroxymethyl)aminomethane] Schiff bases

Bioinspired and eco-friendly high efficacy cinnamaldehyde antibacterial surfaces

“…Previously it has been reported that tris(hydroxymethyl)aminomethane can undergo Schiff base reaction with carbonyl-containing compounds, yielding CQN infrared stretching frequencies in the region of 1640-1630 cm À1 . 71,72 Tris(hydroxymethyl)aminomethane and cinnamaldehyde are present in almost equimolar amounts in the tannic acid-cinnamaldehyde coating solution, whereas in the polydopamine-cinnamaldehyde coating solution there is a significant excess of cinnamaldehyde relative to tris(hydroxymethyl) aminomethane (which masks the imine bond region of the infrared absorption). Tannic acid is also capable of reacting with amines via the Schiff base reaction to form an iminehowever, the wavenumber for such imine group stretching should be much lower (1585 cm À1 ), thus making it unlikely that this new peak is due to the reaction of tannic acid with tris(hydroxymethyl)aminomethane to form an imine.…”

Synthesis, spectroscopic, and computational studies on molecular charge-transfer complex of 2-((2-hydroxybenzylidene) amino)-2-(hydroxymethyl) propane-1, 3-diol with chloranilic acid: Potential antiviral activity simulation of CT-complex against SARS-CoV-2

“…The solid CT complex is prepared as follow: Synthesis of Schiff`s base [ SAL-THAM] derived from salicylaldehyde and Tris-(hydroxymethyl)aminomethane, THAM, as previously described [34] . Addition of 1.25 mmol of ethanolic solution of CLA (0.0261 g, in 25 mL of EtOH) to 1.25 mmol of [SAL-THAM] (0.0281g, in 25 mL of EtOH), and applying reflux for 3 hours at 80 ○ C. The solution was allowed to gently evaporate at room temperature, yielding a pink solid.…”

“…Synthesis of Schiff`s base [ SAL-THAM] derived from salicylaldehyde and Tris-(hydroxymethyl)aminomethane, THAM, as previously described [34] .…”

“…In the current study, we aim to (1) Synthesis of a novel charge transfer complex derived from the previously prepared THAM-SAL Schiff's base [34] and chloranilic acid (CLA), (2) Investigate the behavior of the new prepared CT complex in different polar solvents as ethanol, methanol, and acetonitrile using UV-Vis absorption spectra, (3) Study the influence of increasing the concentration of the electron donor on the formed CT-complex and deducing its formation constants in the three solvents. (4) Apply computational studies; (a) to determine the stabilization energy for the formed CT complex as well as its geometrical parameters (bond lengths and bond angles) using PCM as solvation model for energy minimization together with TD-DFT (b) presenting the molecular potential energy surface, as well as the HOMO and LUMO molecular orbitals of the produced complex, (c) visualizing non-covalent interaction (NCI) in the molecules, and (d) The antiviral activity of CT - complex against SARS-CoV-2 coronavirus protease with the target of COVID-19 protease enzymes was demonstrated utilizing DFT and molecular docking simulation.…”

Crystal structure of 2-[(1E)-{[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]iminiumyl}methyl]-5-(dodecyloxy)benzen-1-olate, C23H39NO5

“…In connection with recent studies of diorganotin Schiff bases derived from tris[(hydroxymethyl)aminomethane] [6,7], largely motivated by the promising cytotoxicities they exhibit [6], the structure of the title tris[(hydroxymethyl) aminomethane] Schiff base derivative, featuring an appended n-dodecyl substituent, was prepared and studied crystallographically. The molecular structure is shown in the figure (50% displacement ellipsoids) and crystallography confirms the molecule existing as a zwitterion in the solid-state.…”