Synthesis, characterization and controlled drug release of thermosensitive IPN–PNIPAAm hydrogels

Zhang, Xian‐Zheng; Wu, Daqing; Chu, Chih‐Chang

doi:10.1016/j.biomaterials.2003.10.065

Cited by 441 publications

(306 citation statements)

References 51 publications

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“…The use of the difunctional monomer MBA in the reacting mixture promotes the formation of a tridimensional interpenetrated polymer network reinforcing the mechanical properties of the hydrogel as well as restraining its swelling capacity [28]. During the alkaline treatment, amide groups are hydrolyzed into carboxylate ions.…”

Section: Synthesis and Spectral Characterizationmentioning

confidence: 99%

Interpenetrated Chitosan-Poly(Acrylic Acid-Co-Acrylamide) Hydrogels. Synthesis, Characterization and Sustained Protein Release Studies

Povea¹,

Argüelles‐Monal²,

Cauich-Rodríguez³

et al. 2011

MSA

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Interpenetrated polymer networks of chitosan (CHI), polyacrylic acid (PAA) and polyacrylamide (PAM) were prepared by free radical polymerization. These hydrogels were either washed with double distilled water (CHI/PAA/PAM) A or hydrolyzed with 1M sodium hydroxide (NaOH), (CHI/PAA/PAM) S. Both types of hydrogels were characterized by infrared spectroscopy, microstructural techniques and compressive mechanical testing. Finally, hydrogels were loaded with bovine serum albumin (BSA) and release followed at different pHs. Infrared spectra analysis showed correspondence between hydrogels and monomer feed compositions. Hydrolyzed hydrogels, had increased water content and pH swelling dependence. Compression modulus of swelled hydrolyzed hydrogels decreased with increasing equilibrium water content. Higher BSA loadings were achieved on hydrolyzed hydrogels due to their high water content and porosity. Protein release from hydrogels was low ( 20% after 10 hours) at pH 1.2, but sustained release was observed at pH 6.8 and 7.4. The integrity of the protein released at 6.8 and 7.4 by hydrolyzed hydrogels was unaffected. The hydrogles showed no cytotoxic effects on human skin dermal fibroblasts as determined by MTT assay except for two compositions of (CHI/PAA/PAM) A samples, which after seven days presented a viability lower than 80% respect to the control.

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Section: Synthesis and Spectral Characterizationmentioning

confidence: 99%

Interpenetrated Chitosan-Poly(Acrylic Acid-Co-Acrylamide) Hydrogels. Synthesis, Characterization and Sustained Protein Release Studies

Povea¹,

Argüelles‐Monal²,

Cauich-Rodríguez³

et al. 2011

MSA

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show abstract

“…Poly(NIPA) hydrogels with an IPN structure exhibit slightly improved mechanical strength: The compression modulus and tensile modulus of IPN-poly(NIPA) hydrogels are, respectively, 3.5 and 16.8 times higher than those of conventional poly(NIPA) hydrogels. 26 A semi-IPN created by combining poly (acrylic acid) and a porous poly(NIPA) hydrogel also shows fast responses to both temperature and pH changes. 27 If a small amount of hydrophilic moieties is introduced into the hydrogel network, hydrophobic aggregation on the hydrogel surface decreases; consequently, the formation of a thick, impermeable skin layer is protected to give fast thermoresponsiveness.…”

Section: Fast Stimuli-sensitive Hydrogelsmentioning

confidence: 99%

Recent advances in hydrogels in terms of fast stimuli responsiveness and superior mechanical performance

Imran

Seki

Takeoka

2010

Polym J

139

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This review addresses the potential development of polymer hydrogels in terms of fast stimuli responsiveness and superior mechanical properties. The slow response and mechanical weakness of stimuli-sensitive hydrogels have been considered as the main barriers for their further development and practical application. It has been a dream of scientists to have fast stimuliresponsive hydrogels with superior mechanical performance. In this review, the principal reasons behind the poor stimulus sensitivity and mechanical strength of polymer gels are highlighted, and we present some pioneering physical and chemical efforts aimed at fabricating hydrogels with high stimuli sensitivities and/or superior mechanical properties. Polymer Journal ( Keywords: butterfly pattern; fast stimuli sensitivity; hydrogel; LCST; mechanical property INTRODUCTION Polymer hydrogels (hereafter called 'hydrogels') are three-dimensional polymer networks in which the voids are filled with water. These hydrogels are widely used in a variety of industrial and consumer products such as oil dewatering systems, mechanical absorbers, diapers and contact lenses. One of the most remarkable areas of research on hydrogels in the past few decades has been their stimulus sensitivity. Hydrogels composed of stimuli-responsive polymers reversibly alter their shape and volume in response to small variations in the environment, such as pH, temperature, light and electric and magnetic fields, thereby changing their physico-chemical characteristics. 1 Among all of the available environmentally responsive hydrogels, temperature-responsive hydrogels have attracted the most attention because of the facile tuning of their properties. In particular, poly(Nisopropylacrylamide) (poly(NIPA)) hydrogels have been widely investigated as thermosensitive hydrogels. Poly(NIPA) has a low critical solution temperature (LCST) at around 32 1C in water. The flexible coil of poly(NIPA) (soluble) converts into a compact globular state (insoluble) at the LCST, and this conformational change is reversible. 2 Thus, hydrogels composed of poly(NIPA) undergo a reversible volume change at a similar transition temperature in water. Poly(NIPA) hydrogels have potential applications in drug delivery systems, therapeutic agents, diagnostic devices, biomaterials, cell cultivation, biocatalysts, sensors, microfluidic devices, actuators, optical devices and size-selective separation among others. [3][4][5] A recent subject that has attracted much attention in the field of gel science is the fabrication of hydrogels with the rapid stimuli responsiveness and superior mechanical properties required for many applications of stimuli-responsive hydrogels. The creation of durable

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“…e lower critical solution temperature (LCST) of poly(PNIPAAm) can therefore be adjusted by performing copolymerization conjugation with other reactive monomers [106].…”

Section: Ermosensitive Hydrogel Materialsmentioning

confidence: 99%

Hydrogels for the Application of Articular Cartilage Tissue Engineering: A Review of Hydrogels

Chuang

Chiang

Wong

et al. 2018

Advances in Materials Science and Engineering

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e treatment of articular cartilage damage is a major task in the medical science of orthopedics. Hydrogels possess the ability to form multifunctional cartilage grafts since they possess polymeric swellability upon immersion in an aqueous phase. Polymeric hydrogels are capable of physiological swelling and greasing, and they possess the mechanical behavior required for use as articular cartilage substitutes. e chondrogenic phenotype of these materials may be enhanced by embedding living cells. Artificial hydrogels fabricated from biologically derived and synthesized polymeric materials are also used as tissue-engineering scaffolds; with their controlled degradation profiles, the release of stimulatory growth factors can be achieved. In order to make use of these hydrogels, cartilage implants were formulated in the laboratory to demonstrate the bionic mechanical behaviors of physiological cartilage. is paper discusses developments concerning the use of polymeric hydrogels for substituting injured cartilage tissue and assisting tissue growth. ese gels are designed with consideration of their polymeric classification, mechanical strength, manner of biodegradation, limitations of the payload, cellular interaction, amount of cells in the 3D hydrogel, sustained release for the model drug, and the different approaches for incorporation into adjacent organs. is article also summarizes the different advantages, disadvantages, and the future prospects of hydrogels.

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Synthesis, characterization and controlled drug release of thermosensitive IPN–PNIPAAm hydrogels

Cited by 441 publications

References 51 publications

Interpenetrated Chitosan-Poly(Acrylic Acid-Co-Acrylamide) Hydrogels. Synthesis, Characterization and Sustained Protein Release Studies

Interpenetrated Chitosan-Poly(Acrylic Acid-Co-Acrylamide) Hydrogels. Synthesis, Characterization and Sustained Protein Release Studies

Recent advances in hydrogels in terms of fast stimuli responsiveness and superior mechanical performance

Hydrogels for the Application of Articular Cartilage Tissue Engineering: A Review of Hydrogels

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