Synthesis, characterization and crystal structures of two pentagonal-bipyramidal Fe(III) complexes with dihydrazone of 2,6-diacetylpyridine and Girard's T reagent. Anticancer properties of various metal complexes of the same ligand

Abstract

Pentagonal-bipyramidal Fe(III) complexes with dihydrazone of 2,6-diacetylpyridine and Girard's T reagent have been synthesized and characterized. Cytotoxic activity of Fe(III) complexes and Co(II), Ni(II), Mn(II), Zn(II) and Cd(II) complexes with the same ligand was tested. The best activity was observed in the case of Fe(III), Co(II) and Cd(II) complexes.

Cobalt(II), Zinc(II), Iron(III), and Copper(II) Complexes Bearing Positively Charged Quaternary Ammonium Functionalities: Synthesis, Characterization, Electrochemical Behavior, and SOD Activity

“…The field of their application is quite broad and includes the design of coordination polymers, supramolecular assemblies, and nanostructures, nanomagnets, as well as investigations of spin‐crossover and magnetic relaxation processes,, photo‐induced transformations, and magnetic anisotropy . Even more, the PBP 3 d metal complexes of diacetylpyridine bis(hydrazone) ligands also emerged as bioactive compounds and superoxide dismutase (SOD) mimetics . Importantly, related PBP complexes of pyridine‐containing pentaazamacrocycles belong to one of the most prominent classes of SOD mimetics that entered clinical trials, with a representative complex that exceeds the SOD activity of the natural enzyme .…”

Molecular Structures and Spin‐States of Pseudohalide Metal Complexes with Hydrazones of Girard's T Reagent

“…Isothiocyanato complexes of Mn II {[Mn( H 2 L 4 )(NCS) 2 ](SCN) 2 · CH 3 OH} ( 10 ), Co II {[Co( H 2 L 4 )(NCS) 2 ](SCN) 2 · 2 H 2 O ( 11 ) and [Co( H 2 L 4 )(NCS) 2 ][Co(NCS) 4 ] · 2 H 2 O ( 12 )}, Ni II {[Ni( H 2 L 4 )(NCS) 2 ](SCN) 2 · 2 H 2 O ( 13 )}, Zn II {[Zn( H 2 L 4 )(NCS) 2 ][Zn(NCS) 4 ] · 2 H 2 O ( 14 )}, and Cd II {[Cd( H 2 L 4 )(NCS) 2 ][Cd(NCS) 4 ] · 2 H 2 O ( 15 )} with the condensation product of 2,6‐diacetylpyridine and the Girard T reagent ( H 2 L 4 Cl 2 , Scheme ) were obtained from the dihydrazone ligand, NH 4 SCN, and the corresponding metal(II) salts [chloride in the cases of Mn II ( 10 ), Ni II ( 13 ), Co II ( 11 and 12 ), and Zn II ( 14 ) complexes or nitrate in the case of Cd II complex ( 15 )]. X‐ray analysis of the Mn II , Ni II , and Zn II complexes 10 , 13 , and 14 , respectively, and of the two Co II complexes 11 and 12 showed pentagonal‐bipyramidal (PBPY‐7) coordination in the surroundings of the metal(II), consisting of dihydrazone ligand symmetrically coordinated through N 3 O 2 donor atoms in the equatorial plane and two N‐coordinated NCS – monodentate ligands in axial positions . In contrast with complexes 10 , 11 , and 13 , in complexes 12 , 14 , and 15 the counterion of the PBPY‐7 complex cation is anionic tetrahedral [M(NCS) 4 ] 2– instead of two SCN – ligands …”

“…Complex 16 is a 1:1 electrolyte in DMSO solution. The value of molar conductivity for complex 17 in DMSO solution indicates solvolysis of complex anion [Fe(H 2 O)(NCS) 5 ] 2– in which one or two coordinated SCN – ligands are replaced with molecules of solvent …”

“…That review also covers some pseudohalide metal complexes with Girard T reagent hydrazones reported up until 2012 , . In recent years our two research groups (K. Anđelković and co‐workers and I. Turel and co‐workers) have made significant contributions in research into coordination chemistry of pseudohalide metal complexes with Girard T reagent hydrazones . A summary of pseudohalide metal complexes with Girard T reagent hydrazones reported until now is given in Table .…”

Synthesis, characterization and antimicrobial activity of isothiocyanato Fe(III) Girard's t hydrazone complex

“…Recently, isothiocyanato Fe(III) complexes with dihydrazone of 2,6-diacetylpyridine and Girard's T reagent (H 2 L 1 Cl 2 ) were synthesized. 7 Both iron(III) complexes…”