Synthesis, Characterization and Crystal Structures of Cobalt(II), Zinc(II) and Cadmium(II) Complexes Derived from 2-Hydroxy-N’-(pyridin-2-ylmethylene)benzohydrazide with Antimicrobial Activity

Abstract

Three new cobalt(II), zinc(II) and cadmium(II) complexes, [CoL 2 ] • 2CH 3 OH • H 2 O (1), [ZnL 2 ] (2) and [Cd(HL) 2 (NO 3)] N 3 (3), were prepared from 2-hydroxy-N'-(pyridin-2-ylmethylene)benzohydrazide (HL). The complexes have been characterized by IR, UV-Vis and single-crystal X-ray diffraction techniques. X-ray analysis indicates that the complexes are mononuclear species, with the metal atoms in octahedral coordination. The hydrazone compound and its complexes were evaluated for their antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescence) and antifungal (Candida albicans and Aspergillus niger) activities. The complexes have effective activities against the bacteria.

Synthesis, Crystal Structure, Hirshfeld Surface Analysis, and DFT Calculations of the New Binuclear Copper(I) Complex Containing 2-Benzimidazolethiole and Triphenylphosphine Ligands

“…The medium intensity peak at 3155 cm -1 in the IR spectrum of the ligand (2-BIT) can be attributed to the stretching vibration of the NH group, which is shifted by 17 cm -1 to a lower frequency due to hydrogen bonding because hydrogen bonding weakens the N-H bond, resulting in its absorption frequency being lower. 34 The infrared spectrum of the Cu(I) complex lacked the stretching vibration of the thiol (SH) group at 2562 cm -1 , indicating that the sulfur atom is coordinated to the metal center and the thione tautomer is more dominant than the thiol tautomer. 35 The strong band at 1458 cm -1 related to v(P-C) of the triphenylphosphine ligand.…”

Zinc(II) Complex Containing Oxazole Ring: Synthesis, Crystal Structure, Characterization, DFT Calculations, and Hirshfeld Surface Analysis

“…27 Free 5-chloro-2-methylbenzoxazole shows strong intensity bands at 1608 cm -1 and 1253 cm −1 , with the two bands being assigned to the C=N and C-O stretching vibrations of the oxazole group, respectively. 28,29 The C=N band in the Zn(II) complex (Fig. S2) is shifted to lower wavenumber (1600 cm -1 ) indicating the participation of benzoxazole nitrogen in coordination with the Zn(II) ion.…”

Anion Induced Synthesis, Structural Characterization and Antibacterial Activity of Zinc(II) Complexes Derived from 5-Bromo-2-((2-(diethylamino)ethylimino)methyl) phenol

“…While for Klebsielle pneumonia, complex 2 has stronger activity than the other two. All the complexes have better activities on Staphylococcus aureus and Escherichia coli than the zinc complexes with the ligands 4-methoxybenzoic acid (1-pyridin-2-ylmethylidene) hydrazide and benzoic acid (1-pyridin-2-ylethylidene)hydrazide, 19 the oxovanadium complexes derived from N'-(3-bromo-2-hydroxybenzylidene)picolinohydrazide and 2-chloro-N'-(2-hydroxy-3-methoxybenzylidene)benzohydrazide, 20 the cobalt, zinc and cadmium complexes derived from 2-hydroxy-N'-(pyridin-2-ylmethylene)benzohydrazide, 21 and the nickel complex with the ligand N,N'-bis(5-chloro-2-hydroxybenzylidene)-1,3-propanediamine. 22 Complexes 1 and 3 have better activities on and 2, 4-difluoro-6-((3-morpholinopropylimino)methyl)phenolate, 23 and similar activities with the copper complex derived from 2-hydroxy-5-methylbenzaldehyde oxime.…”