Synthesis, characterization and cytocompatibility of ZrO2 doped borosilicate bioglasses

Samudrala, Raj Kumar; Reddy, Gajulapalli V.N.; Manavathi, Bramanandam; Azeem, P. Abdul

doi:10.1016/j.jnoncrysol.2016.05.001

Cited by 25 publications

(7 citation statements)

References 41 publications

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“…The band at around 506 cm −1 is attributed to the bending vibrations (PO 4 3− ) of O–P–O [ 15 , 16 , 22 ] The absorption bands at 752 cm −1 and 978 cm −1 are due to the (P–O–P) symmetric stretching vibrations of phosphate group [ 10 , 23 ]. The peak observed at 1642 cm −1 is assigned due to the stretching vibrations of P–O–H groups (water molecule) [ 9 ]. A minor peak at around 2382 cm −1 is due to CO 3 2− and HCO 3 − groups [ 23 , 24 ] and a wide intense band at 3464 cm −1 is ascribed to the symmetric stretching of O–H groups [ 9 ].…”

Section: Resultsmentioning

confidence: 99%

“…The peak observed at 1642 cm −1 is assigned due to the stretching vibrations of P–O–H groups (water molecule) [ 9 ]. A minor peak at around 2382 cm −1 is due to CO 3 2− and HCO 3 − groups [ 23 , 24 ] and a wide intense band at 3464 cm −1 is ascribed to the symmetric stretching of O–H groups [ 9 ].…”

Section: Resultsmentioning

confidence: 99%

“…The band at around 506 cm −1 is attributed to the bending vibrations (PO 4 3− ) of O-P-O [15,16,22] The absorption bands at 752 cm −1 and 978 cm −1 are due to the (P-O-P) symmetric stretching vibrations of phosphate group [10,23]. The peak observed at 1642 cm −1 is assigned due to the stretching vibrations of P-O-H groups (water molecule) [9].…”

Section: Ftir Spectroscopic Analysismentioning

confidence: 98%

“…Out of all these glasses, phosphate-based glasses have many advantages, due to solubility, high biocompatibility and low melting temperature etc., which made them suitable to be used as biomaterials [ 7 ]. The strong glass former P 2 O 5 contributes in the glass network, as PO 4 structural units [ 6 , 8 , 9 ] are due to covalent bonding by the bridging oxygens. This bioglass material upon immersion in the simulated body fluid (SBF) solution shows a state where the ionic and pH conditions perfectly simulate with human blood plasma [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…This can be resolved by incorporating suitable transition metal ions, such as TiO 2 , MgO, ZnO, CuO, Fe 2 O 3 , etc., to phosphate glass network in appropriate amounts. The first generations of biomaterials are directly related to the bone and tissue engineering by the implantation of ZrO 2 and TiO 2 -based materials [ 9 , 10 , 11 ]. The first research paper on zirconia was published by Helmer and Driskel in 1969 and mentioned that ZrO 2 can be used as a biomaterial [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Influence of ZrO2 Addition on Structural and Biological Activity of Phosphate Glasses for Bone Regeneration

et al. 2020

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Zirconium doped calcium phosphate-based bioglasses are the most prominent bioactive materials for bone and dental repair and regeneration implants. In the present study, a 8ZnO–22Na2O–(24 − x)CaO–46P2O5–xZrO2 (0.1 ≤ x ≤ 0.7, all are in mol%) bioglass system was synthesized by the conventional melt-quenching process at 1100 °C. The glass-forming ability and thermal stability of the glasses were determined by measuring the glass transition temperature (Tg), crystallization temperature (Tc), and melting temperature (Tm), using differential thermal analysis (DTA). The biological activity of the prepared samples was identified by analyzing X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy-energy dispersive spectra (SEM-EDS), before and after immersion in simulated body fluid (SBF) for various intervals of 0, 1 and 5 days, along with the magnitude of pH and the degradation of glasses also evaluated. The obtained results revealed that the glass-forming ability and thermal stability of glasses increased with the increase in zirconia mol%. The XRD, FTIR, and SEM-EDS data confirmed a thin hydroxyapatite (HAp) layer over the sample surface after incubation in SBF for 1 and 5 days. Furthermore, the development of layer found to be increased with the increase of incubation time. The degradation of the glasses in SBF increased with incubation time and decreased gradually with the increase content of ZrO2 mol% in the host glass matrix. A sudden rise in initial pH values of residual SBF for 1 day owing to ion leaching and increase of Ca2+ and PO43− ions and then decreased. These findings confirmed the suitability of choosing material for bone-related applications.

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