Synthesis, characterization and cytotoxicity evaluation of some new platinum(II) complexes of tetrazolo[1,5-a]quinolines

Synthesis of 6-N-R-Tetrazolo[1,5-c]quinazolin-5(6H)-ones and Their Anticancer Activity

“…[2][3][4][5] Also, the anticancer activity of tetrazol was recently reported. [6][7] Thus, platinum(II) complexes ( 8 Moreover, fibrinolytic and bronchodilating activities of such compounds were claimed by several US patents. 9,10 Our latest investigations of substituted condensed tetrazolo [1,5-c]quinazolines have also proved their potential as pharmaceutical agents, namely anticancer (N-(benzo[d]thiazol-2-yl)-2-(tetrazolo [1,5-c]quinazolin-5-ylthio)acetamides against cells of melanoma), antimicrobial (1-(2,5-dimethoxyphenyl)-2-(tetrazolo [1,5-c]quinazolin-5-ylthio)ethanone against Staphylococcus aureus), antifungal (5-(3-chloropropylthio)tetrazolo [1,5-c]quinazoline against Candida albicans), and bioluminescence inhibition properties.…”

Synthesis, molecular docking and biological evaluation of some novel tetrazolo[1,5-a]quinoline incorporated pyrazoline and isoxazoline derivatives

“…Tetrazoles are bioisosteres of the carboxyl group and act as ligand-binding functionality for CYP450-derived oxidative metabolic processes (Herr, 2002). The tetrazole group possesses wide range of biological activities such as cytotoxic (Bekhit et al, 2004a), anti-inflammatory (Bekhit et al, 2004b), antimicrobial (Kategaonkar et al, 2010) and even recognized as inhibitor of hepatitis C virus (HCV) (Thota et al, 2008). This prompted us constructing novel compounds containing fused quinoline and tetrazole ring systems in the same matrix to serve as a new pharmacophore.…”

Synthesis, structural investigation, thermal decomposition mechanism and sensitivity properties of an energetic compound [Cd(DAT)6](ClO4)2 (DAT=1,5-diaminotetrazole)

“…Tetrazole derivatives have gained more and more attention as ligands to transition metals [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. The high positive enthalpies of formation and high nitrogen content of tetrazoles have made their complexes interesting for energetic materials.…”