Synthesis, characterization and cytotoxicity of new gold(III) complexes with 1,2-diaminocyclohexane: Influence of stereochemistry on antitumor activity

Al-Jaroudi, Said S.; Fettouhi, Mohammed; Wazeer, Mohamed I. M.; Isab, Anvarhusein A.; Altuwaijri, Saleh

doi:10.1016/j.poly.2012.11.034

Cited by 31 publications

(29 citation statements)

References 49 publications

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“…It was also observed that Tu reacted faster than DIAZ toward these complexes. A faster rate of reaction for [Au( cis ‐DACH)Cl 2 ]Cl justifies its greater anticancer activity compared to that of [Au( cis ‐DACH) 2 ]Cl 3 .…”

Section: Resultsmentioning

confidence: 99%

“…Gold complexes are emerging as a new class of metal‐based drugs with promising antitumor properties, since a number of gold(I) and gold(III) complexes have been reported to possess significant cytotoxic effects against various human cancer cell lines . In some cases, they are more effective than cisplatin, a typical anticancer drug .…”

Section: Introductionmentioning

confidence: 99%

“…We recently reported the synthesis and characterization of gold(III) complexes with DACH and examined the effect of stereochemistry of DACH on tumor activity . Additionally, the interaction of gold(III) complexes with cyanide and some thiolates has been studied.…”

Section: Introductionmentioning

confidence: 99%

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Spectroscopic and Electrochemical Studies of the Interaction of Some Gold(III) Complexes with Biologically Relevant Thiones

Sulaiman

Omer

Kawde

et al. 2018

Int J of Chemical Kinetics

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The interaction of gold(III) complexes, [Au(cis‐DACH)Cl2]Cl and [Au(cis‐DACH)2]Cl3 complexes (DACH = cis‐1,2‐diaminocyclohexane), with 13C, 15N‐enriched thiourea (Tu) and 1,3‐diazinane‐2‐thione ligands was investigated. The progress of these reactions was monitored by NMR (1H, 13C, and 15N) and UV–vis spectroscopy as well as square wave stripping voltammetry. The kinetic studies of the substitution reactions between the above‐mentioned complexes with thiones in aqueous solutions containing 30 mM KCl, which is used to suppress the hydrolysis of the chloride complexes, were conducted. These reactions were followed under pseudo–first‐order conditions as functions of ligand concentration, pH, and temperature. The activation parameters (ΔH#, ΔS#) were calculated from Eyring plots, and the negative values of ΔS≠ lend support for an associative mechanism. The kinetic data also indicated a relatively higher reactivity of [Au(cis‐DACH)Cl2]Cl than that of [Au(cis‐DACH)2]Cl3 toward the thiones.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Spectroscopic and Electrochemical Studies of the Interaction of Some Gold(III) Complexes with Biologically Relevant Thiones

Sulaiman

Omer

Kawde

et al. 2018

Int J of Chemical Kinetics

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“…Their cytotoxic activity was claimed against human prostate and gastric cancer. In this context, two papers involving similar compounds with bis-chelated Ndonor ligands (DACH-DACH or DACH-ethylenediamine) were recently published [104,105].…”

Section: Gold(iii)-based Derivatives: Fields Of Application Structurmentioning

confidence: 99%

Gold Complexes for Therapeutic Purposes: an Updated Patent Review (2010-2015)

Nardon¹,

Pettenuzzo²,

Fregona

2016

CMC

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Gold has always aroused great interest in the history of mankind. It has been used for thousands of years for jewelry, religious cult valuables, durable goods and in the art world. However, few know that such a precious and noble metal was exploited in the past by the ancients also for its therapeutic properties. More recently, in the twentieth century some complexes containing gold centers in the oxidation state +1 were studied for the treatment of the rheumatoid arthritis and the orally-administered drug Auranofin was approved by the FDA in 1985. From the chemical point of view, gold derivatives deserve special attention due to the unique position of this metal within the periodic table, which results in unconventional relativistic effects and, ultimately, in the highest electronegativity, electron affinity and redox potential among all metals. In this review, after an introduction concerning the use of gold complexes in medicine, we have examined all the patents internationally or nationally published in the years 2010-2015 (until December 31, 2015) and describing new inorganic compounds containing gold(I) and gold(III) with proved therapeutic properties. These patents were filed to mainly protect compounds with promising anticancer and anti-inflammatory activities (total 18 and 4, respectively). In particular, this work explores both coordination compounds containing ligands with various donor atoms (e.g., N-, O-, S- and -P) and organo-gold derivatives with at least one Au-C bond. The toxicological profile and the intracellular targets reported for some among the patented gold derivatives are discussed.

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“…In our research group, we focused on design and exploration of precious metal complexes as anticancer agents [31][32][33]. This communication deals with the synthesis, crystal structure and anticancer activity of a new platinum (II) complex [Pt(Diaz) 4 ]Cl 2 • H 2 O of the heterocyclic thione, 1-3-diazinane-2-thione (Diaz) (See Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

Tetrakis(1-3-diazinane-2-thione)platinum(II) chloride monohydrate complex: Synthesis, spectroscopic characterization, crystal structure and in vitro cytotoxic activity against A549, MCF7, HCT15 and HeLa human cancer lines

Mustafa

Altaf

Monim-ul-Mehboob

et al. 2014

Inorganic Chemistry Communications

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Synthesis, characterization and cytotoxicity of new gold(III) complexes with 1,2-diaminocyclohexane: Influence of stereochemistry on antitumor activity

Cited by 31 publications

References 49 publications

Spectroscopic and Electrochemical Studies of the Interaction of Some Gold(III) Complexes with Biologically Relevant Thiones

Spectroscopic and Electrochemical Studies of the Interaction of Some Gold(III) Complexes with Biologically Relevant Thiones

Gold Complexes for Therapeutic Purposes: an Updated Patent Review (2010-2015)

Tetrakis(1-3-diazinane-2-thione)platinum(II) chloride monohydrate complex: Synthesis, spectroscopic characterization, crystal structure and in vitro cytotoxic activity against A549, MCF7, HCT15 and HeLa human cancer lines

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