Synthesis, characterization and cytotoxicity of some palladium(II), platinum(II), rhodium(I) and iridium(I) complexes of ferrocenylpyridine and related ligands. Crystal and molecular structure of trans-dichlorobis(3-ferrocenylpyridine)palladium(II)

Bis(ferrocenylimine)palladium(II) and platinum(II) complexes: Synthesis, molecular structures and evaluation as antitumor agents

“…This coordination mode is confirmed in the crystal structures of complexes 3 and 6 ( Fig.s 1 and 2). The binding is similar to that of related ferrocenylpyridine complexes reported in the literature [12].…”

“…This observation suggests that the complex precipitated back to its undissolved state thus limiting its bioavailability. Similarly, some complexes containing ferrocenyl ligands have also been reported and the attempt to evaluate their cytotoxicity was hindered by this insolubility phenomenon [12].…”

“…Ferrocene derivatives containing atoms with good donor abilities have attracted research interest because coordination of a metal to these heteroatoms produces multicentre molecules with metals in close proximity, but in different environments, which may influence the mutual cooperation of the metals in a variety of processes [9][10][11]. Furthermore, some ferrocenyl complexes have also been investigated for their anti-cancer activity, and exhibited promising cytotoxic activities [12][13]. The starting point in the development of new ferrocenyl derivatives as anticancer agents could be traced back to the discovery of the ferrocenium cation as an anticancer agent [14][15][16].…”

“…The starting point in the development of new ferrocenyl derivatives as anticancer agents could be traced back to the discovery of the ferrocenium cation as an anticancer agent [14][15][16]. However literature reviews show conflicting conclusions about the important features in ferrocenyl compounds which could be responsible for their cytotoxic activities [12][13].…”

Synthesis, physical and antimicrobial studies of ferrocenyl-N-(pyridinylmethylene)anilines and ferrocenyl-N-(pyridinylmethyl)anilines

“…7,8 The ferrocenyl unit is also known to modify the shapes of molecules as well as the physical properties such as colour, polarizability and magnetism. 9 Generally, studies on ferrocene revolve around generation of compounds that are used in materials science, 10 electrochemistry 11,12 catalysis, [13][14][15] medicinal applications [16][17][18][19][20][21][22][23][24] and nonlinear optics 25,26 amongst others. Ferrocene derivatives containing organic fragments bearing one or more heteroatoms such as sulphur, 27 nitrogen, 28 oxygen, 29 and phosphorous 30 have gained prominence.…”