Synthesis, characterization and DNA binding properties of oligopyridine-ruthenium(II)-amino acid conjugates

Custom‐Fit Ruthenium(II) Metallopeptides: A New Twist to DNA Binding With Coordination Compounds

“…As expected, no measurable binding was detected in control experiments with single-stranded DNA oligonucleotides. Circular dichroism (CD) experiments show an induced CD band at 320 nm by the LL-Ru 2 isomer (the Supporting Information, Figure S4 a), which has been also reported for other Ru II complexes, [27] but, more importantly, they show that the shape of the CD signals between 200 and 300 nm, corresponding to the DNA, are not significantly perturbed, thus indicating the retention of the B-DNA conformation. [28] Saturation transfer difference (STD) NMR experiments also support the binding to the DNA.…”

Cytotoxicity of half sandwich ruthenium(II) complexes with strong hydrogen bond acceptor ligands and their mechanism of action

“…Among the various metal complexes examined for cytotoxicity, organometallic ruthenium complexes have emerged as one of the most promising class of compounds as they allow a great deal of molecular tinkering and the half sandwich complexes of Ru(II) provide an extremely good scaffold for building new molecules. Research groups of Sadler, Dyson, Keppler and Reedijk have synthesized a remarkably large number of Ru(II)/Ru(III) organometallic complexes that are being tested for anticancer activity [1][2][3][4][5][6][7][8][9][10]. Ruthenium complexes are quite cytotoxic but do not affect normal cells significantly [11,12].…”

Highly active neutral ruthenium(II) arene complexes: Synthesis, characterization, and investigation of their anticancer properties

“…An advantage of ruthenium complexes is on the one hand their cytotoxic activity, but on the other hand the fact that they only hardly attack normal cells [16][17][18]. Since the first discovery of ruthenium complexes for cancer research, a large number of ruthenium-based compounds have been investigated and reported in literature by the research groups of Sadler, Dyson and Keppler [19][20][21][22][23][24][25][26][27][28]. Thus, octahedral ruthenium(III) complexes [imiH]trans-[Ru(N-imi)(S-dmso)Cl 4 ] (imi= imidazole; type I in Fig.…”