Synthesis, characterization and DNA binding studies of ruthenium(II) complexes: [Ru(bpy)2(dtmi)]2+ and [Ru(bpy)2(dtni)]2+

Liu, Yun-Jun; Wei, Xin; Mei, Wenjie; He, Lixin

doi:10.1007/s11243-007-0246-y

Cited by 23 publications

(4 citation statements)

References 32 publications

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“…Among the synthesized metal complexes copper complex acts as a higher metallointercalator compared to other complexes. Thus, the results specify that the binding order depends upon the ionic radius, size and charge on the metal ion, which indicate that the metal ion plays a crucial role in DNA binding affinity of these complexes …”

Section: Resultsmentioning

confidence: 74%

Probing of effective pyrazolone based metallonucleases: Molecular docking and in vitro biological critiques

Arunadevi¹,

Paulpandiyan²,

Raman³

2018

Applied Organom Chemis

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Four novel tryptophan based metal (II) complexes of the type [ML (Try)2] were prepared by using pyrazolone derived Schiff base ligand. The proposed structure was confirmed by physicochemical methods which reveal octahedral coordination environment around the metal center. Intercalative binding mode of the complexes with CT DNA was confirmed by electronic absorption titration, viscosity measurements and fluorescence spectroscopy. Efficiency of DNA cleavage ability of the metal complexes was explored by the gel electrophoresis technique. The antimicrobial activities of the metal complexes showed potent biocidal activity. The percentage of free radical scavenging activity shows that the complexes are very reactive towards DPPH. Moreover, their cytotoxicity was tested against the two cancer cell lines (MCF‐7 and HepG2) and one normal cell line (NHDF) respectively. The MTT assay shows that the complexes have the anticancer efficacy. Moreover, the complexes exhibit a limited cytotoxicity effect on normal cell line NHDF. The morphological changes of apoptosis cell death were investigated by using Hoechst 33258 staining method. In addition, the Molecular docking studies was executed to consider the nature of binding and binding affinity of the synthesized compounds with DNA (PDB: 1BNA) and protein (PDB: 3hb5).

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Section: Resultsmentioning

confidence: 74%

Probing of effective pyrazolone based metallonucleases: Molecular docking and in vitro biological critiques

Arunadevi¹,

Paulpandiyan²,

Raman³

2018

Applied Organom Chemis

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“…Thus, due to constriction of phenyl at the intercalation site, binding ability of complex is reduced 27. On internal comparison, it is found that the electron‐withdrawing substituent on 4th position has high DNA binding affinity compared to that on 3rd position 28…”

Section: Resultsmentioning

confidence: 99%

On‐Chip Fragment‐Based Approach for Discovery of High‐Affinity Bivalent Inhibitors

Miyazaki¹,

Simizu²,

Ishida³

et al. 2009

ChemBioChem

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Covalent bonds not required: We describe a novel approach in which the concepts of fragment‐based ligand discovery are combined with chemical array techniques to yield bivalent inhibitors. A pair of fragments is mixed and covalently attached to a glass slide by photolinking immobilization. The method does not require the compounds to have specific functional groups, and tedious steps for protein purification are avoided. Thus, the on‐chip fragment‐based approach is relatively simple and efficient for obtaining high‐affinity ligands.magnified image

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“…The values of DG 0 T , DH 0 , and DS 0 for complexes 1, 2, and [Ru-(bpy) 2 (dtmi)] 2? [51] are shown in Table 3. The negative binding free energies suggest that the sum of the free energies of the free complex [Ru(bpy) 2 (ITAP)] 2?…”

Section: Thermal Denaturation Studymentioning

confidence: 99%

Synthesis and DNA interaction studies of ruthenium(II) complexes with isatino[1, 2-b]-1,4,8,9-tetraazatriphenylene as an intercalative ligand

Liu

Zeng

2009

Transition Met Chem

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The binding of the ruthenium(II) complexes [Ru(bpy) 2 (ITAP)](ClO 4 ) 2 (bpy = 2,2'-bipyridine) and [Ru(phen) 2 (ITAP)](ClO 4 ) 2 (phen = 1,10-phenanthroline, ,4,8,9-tetraazatriphenylene) to calf thymus DNA (CT-DNA) have been investigated with UVvisible and emission spectroscopy, viscosity measurements, thermal denaturation, and photoactivated cleavage. The experimental results indicate that the two complexes bind to CT-DNA through an intercalative mode. The two Ru(II) complexes in the presence of plasmid pBR322 DNA have been found to give rise to nicking of DNA upon irradiation.

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Synthesis, characterization and DNA binding studies of ruthenium(II) complexes: [Ru(bpy)2(dtmi)]2+ and [Ru(bpy)2(dtni)]2+

Cited by 23 publications

References 32 publications

Probing of effective pyrazolone based metallonucleases: Molecular docking and in vitro biological critiques

Probing of effective pyrazolone based metallonucleases: Molecular docking and in vitro biological critiques

On‐Chip Fragment‐Based Approach for Discovery of High‐Affinity Bivalent Inhibitors

Synthesis and DNA interaction studies of ruthenium(II) complexes with isatino[1, 2-b]-1,4,8,9-tetraazatriphenylene as an intercalative ligand

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