Synthesis, characterization and DNA binding/cleavage, protein binding and cytotoxicity studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes of aminonaphthoquinone

Kosiha, A.; Parthiban, C.; Elango, Kuppanagounder P.

doi:10.1016/j.jphotobiol.2017.02.010

Cited by 34 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further, the bright patches observed in the ligand and complex were higher in MCF‐7 and A549 cancer cells. These results are further supportive of the cell toxicity and apoptotic cell death by compounds …”

Section: Resultssupporting

confidence: 68%

See 1 more Smart Citation

A pseudo trinuclear nickel–sodium complex containing tris(8‐methyl‐2‐oxo‐quinolidineamino ethylamine): Synthesis, spectral characterization, X‐ray crystallography and in vitro biological evaluations

Naveen

Pandiyan

Anu

et al. 2020

Applied Organom Chemis

View full text Add to dashboard Cite

A new mixed nickel–sodium complex has been synthesized from Ni(ClO4)2 and tris(8‐methyl 2‐oxo‐quinolidine amino ethylamine) with a 1:1 molar ratio in methanol and has been characterized by various analytical, spectroscopy and X‐ray diffraction studies which confirmed an octahedral geometry around the nickel ion. Further, structural optimization of the complex was performed using DFT calculations. The ligand and complex were evaluated for their binding affinity with CT‐DNA and an intercalative type of binding interaction was proposed from the absorption and fluorescence titration experiments. Albumin binding interaction of the ligand and complex was determined by absorption, fluorescence and synchronous spectral techniques at room temperature, suggesting the static quenching mechanism of BSA with the compounds. Antioxidant studies revealed the radical scavenging potential of Ni(II) complex. The anticancer activity of the ligand and complex was probed via in vitro cytotoxicity against human breast (MCF7) and lung (A549) cancer cell lines by MTT assay. Further, cytological changes observed in acridine orange/ethidium bromide and DAPI staining methods validated the cytotoxic potential of the complex.

show abstract

Section: Resultssupporting

confidence: 68%

“…These results are further supportive of the cell toxicity and apoptotic cell death by compounds. [83] 4 | CONCLUSION…”

Section: Dapi Staining Methodsmentioning

confidence: 99%

A pseudo trinuclear nickel–sodium complex containing tris(8‐methyl‐2‐oxo‐quinolidineamino ethylamine): Synthesis, spectral characterization, X‐ray crystallography and in vitro biological evaluations

Naveen

Pandiyan

Anu

et al. 2020

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

“…As compared to cisplatin, as well as some recently reported copper and zinc complexes, the IC50 value of complex 1 against HeLa cells suggests a stronger cytotoxic action of this complex than that of cisplatin and other complexes [58,59]. Both complexes showed potential cytotoxicity as compared to recently reported copper and zinc complxes of aminonaphthoquinone derivative [60]. Thus, complex 1 turned out to be a potential cytotoxic complex which war-rants a deeper investigation to enable it as a lead anticancer drug.…”

Section: Cytotoxic Studymentioning

confidence: 64%

Synthesis, structures, nuclease activity, cytotoxicity, DFT and molecular docking studies of two nitrato bridged homodinuclear (Cu-Cu, Zn-Zn) complexes containing 2,2′-bipyridine and a chalcone derivative

Gaur

Choubey

Usman

et al. 2017

Journal of Photochemistry and Photobiology B: Biology

View full text Add to dashboard Cite

Nitrato briged dinuclear complexes of type [Cu(L)(bpy)(NO)](NO)·4HO, 1 and [Zn(L)(bpy)(NO)](NO)·4HO, 2 (L=deprotonated form of free ligand LH, [1-(2-hydroxyphenyl)-3-(9-anthracenyl) propenone; bpy=2,2'bipyridine] are synthesized and characterized using a battery of physicochemical techniques and X-ray crystallography. A distorted square pyramidal geometry is assigned to them with NO coordination core around the metal ion. The co-ligand L binds the metal ions through its O,O' atoms in anti-syn mode. The metal centers in complexes 1 and 2 are separated via bridging nitrato group at a distance of 6.073Å and 5.635Å respectively. Their structures and absorption spectra are supported by the computational studies using density functional theory (DFT) and TD-DFT. Both complexes exhibit nuclease activity and cleave supercoiled (form I) DNA. The complex 1 preferentially binds major groove of DNA and follows an oxidative pathway whereas complex 2 binds with minor groove of DNA via hydrolytic pathway. Both complexes inhibit topoisomerase I relaxation activity with IC values of 7 and 35μM. Molecular docking studies support the groove binding and topoisomerase I binding of the complexes. The complex 1 showed a significant cytotoxicity against HeLa cell lines (a cervical cancer cell lines) in vitro with IC value calculated as 2.9±0.021μM as compared to 28.2±0. 044μΜ for complex 2. Complex 2 induces the cell apoptosis at a later-stage as compared to complex 1. The cell apoptosis and topoisomerase inhibition by complexes enable them to be potential candidates as future anticancer drugs.

show abstract

“…As shown in Figures S6 and 11, upon addition of increasing increments of CT‐DNA, there were a remarkable hypochromic (∆ε, 12, 19, 20, 27 and 15%) and bathochromic effect (∆λ, 3, 7, 14, 20 and 10) for H 2 L, Co(II) complex (1), Ni(II) complex (2), Cu(II) complex (3) and Zn(II) complex (4), respectively. These observations suggested non‐covalent intercalating interaction mode . The plot of [CT‐DNA]/(ε a –ε f ) versus [CT‐DNA] for each investigated compound was used to figure, the intrinsic binding constants (Figure insets).…”

Section: Resultsmentioning

confidence: 97%

Synthesis, structural features and biochemical activity assessment of N,N′‐bis‐(2‐mercaptophenylimine)‐2,5‐thiophenedicarboxaldehyde Schiff base and its Co(II), Ni(II), Cu(II) and Zn(II) complexes

Aziz

Seda

2017

Applied Organom Chemis

View full text Add to dashboard Cite

The tetradentate Schiff base ligand (SB), N,N′-bis-(2-mercaptophenylimine)-2,5thiophenedicarboxaldehyde was prepared via condensation of 2,5-thiophenedicarboxaldehyde with 2-aminothiophenol in a 1:2 molar ratio by conventional method. Additionally, its Co(II), Ni(II), Cu(II) and Zn(II) complexes have been synthesized and fully characterized by elemental analysis, FT-IR, 1 H NMR, 13 C NMR, UV-Vis, ESR, ESI-mass, conductivity and magnetic susceptibility measurements. Spectral studies suggested that, the Schiff base coordinate metal ions through the azomethine N-and deprotonated thiol S-atoms. Based on UV-Vis absorption and magnetic susceptibility data, tetrahedral geometry was assigned for both Co(II) and Zn(II) complexes, whereas on the other hand, square planar geometry for both Ni(II) and Cu(II) complexes. The Schiff base and its metal complexes were screened for their in vitro antimicrobial activity by minimum inhibitory concentration (MIC) method. Free radical scavenging activity of the novel compounds was determined by elimination of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. In addition, the interactions of the free ligand and its complexes with calf thymus DNA (CT-DNA) were explored using absorption, emission and viscosity measurements techniques.

show abstract

Synthesis, characterization and DNA binding/cleavage, protein binding and cytotoxicity studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes of aminonaphthoquinone

Cited by 34 publications

References 23 publications

A pseudo trinuclear nickel–sodium complex containing tris(8‐methyl‐2‐oxo‐quinolidineamino ethylamine): Synthesis, spectral characterization, X‐ray crystallography and in vitro biological evaluations

A pseudo trinuclear nickel–sodium complex containing tris(8‐methyl‐2‐oxo‐quinolidineamino ethylamine): Synthesis, spectral characterization, X‐ray crystallography and in vitro biological evaluations

Synthesis, structures, nuclease activity, cytotoxicity, DFT and molecular docking studies of two nitrato bridged homodinuclear (Cu-Cu, Zn-Zn) complexes containing 2,2′-bipyridine and a chalcone derivative

Synthesis, structural features and biochemical activity assessment of N,N′‐bis‐(2‐mercaptophenylimine)‐2,5‐thiophenedicarboxaldehyde Schiff base and its Co(II), Ni(II), Cu(II) and Zn(II) complexes

Contact Info

Product

Resources

About