Synthesis, characterization, and DNA-binding of two new Cd(II) complexes with 8-[(2-pyridylmethyl)amino]-quinoline

Lü, Jing; Sun, Qian; Li, Junling; Gu, Wen; Tian, Jin‐Lei; Liu, Xin; Shi, Yan

doi:10.1080/00958972.2013.832228

Cited by 17 publications

(5 citation statements)

References 33 publications

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“…3). The intramolecular nonbonding CdÁ Á ÁCd distances are comparable with the values (in the range 3.675-4.016 Å ) found in previously reported chloride-bridged cadmium complexes (Park et al, 2010;Wen et al, 2011;Lu et al, 2013;Hopa et al, 2010;Chen et al, 2007). The bridging Cd-Cl bond lengths are also in good agreement within the range of values reported for the corresponding bond lengths of Cd II complexes.…”

Section: Figuresupporting

confidence: 90%

Crystal structure and photoluminescence properties of a new Cd^IIcoordination polymercatena-poly[bis[4-bromo-2-({[2-(pyrrolidin-1-yl)ethyl]imino}methyl)phenolato-κ³N,N′,O]di-μ₃-chlorido-di-μ₂-chlorido-bis(methanol-κO)tricadmium(II)]

et al. 2016

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Schiff base-metal complexes have been used widely as catalysts for many organic reactions, such as ring-opening polymerization and oxidation. In view of the importance of Cd(II) coordination polymers and in an effort to enlarge the library of such complexes, the title novel polymeric Cd(II) tridentate Schiff base complex, [Cd3(C13H16BrN2O)2Cl4(CH4O)2]n, has been synthesized and characterized by elemental analyses, UV and IR spectroscopies, and single-crystal X-ray diffraction. The complex crystallizes in the triclinic P-1 space group with two symmetry-independent Cd(II) atoms, one of which lies on an inversion centre, and analysis of the crystal structure shows that both Cd(II) atoms are six-coordinated; the environment around one Cd(II) atom can be described as distorted octahedral, while that around the second Cd(II) atom is octahedral. The Cd(II) atoms are linked by chloride ligands to form a one-dimensional coordination polymer. The nonbonding intermolecular Cd...Cd distances are 3.7009 (4) and 4.3563 (5) Å. Furthermore, the photoluminescence properties of the complex have been investigated and it displays a strong red emission in the solid state at room temperature.

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Section: Figuresupporting

confidence: 90%

Crystal structure and photoluminescence properties of a new Cd^IIcoordination polymercatena-poly[bis[4-bromo-2-({[2-(pyrrolidin-1-yl)ethyl]imino}methyl)phenolato-κ³N,N′,O]di-μ₃-chlorido-di-μ₂-chlorido-bis(methanol-κO)tricadmium(II)]

et al. 2016

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“…Recently, transition metal complexes containing inorganic metal ions and organic ligands have become the focus of interest due to not only their structural versatility but also their wide range of applications such as antitumor and antibacterial activities, insulin mimetic activities, luminescence properties, catalytic activities, magnetic properties, DNA binding properties and gas adsorption . It is well known that the structural versatility and activity properties of the metal–organic complexes are largely dependent on the choice of organic ligands and metal atoms used, as well as the reaction mechanism in which the complex is obtained.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of the first mixed ligand Mn (II) and Cd (II) complexes of 4‐methoxy‐pyridine‐2‐carboxylic acid, molecular docking studies and investigation of their anti‐tumor effects in vitro

Tamer

Mahmoody

Feyzioğlu

et al. 2019

Applied Organom Chemis

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The first mixed ligand Mn (II) and Cd (II) complexes containing 4‐methoxy‐pyridine‐2‐carboxylic acid (4‐mpic) and 4,4′‐dimethyl‐2,2′‐bipyridine (dmbpy) were synthesized in this study. The geometric structures of [Mn(4‐mpic)2(dmbpy)] (complex 1) and [Cd(4‐mpic)2(dmbpy)] (complex 2) were determined by single crystal X‐Ray diffraction method. FT‐IR and UV–Vis spectra were also recorded to investigate vibrational and electronic properties of complexes 1 and 2. Density functional theory (DFT) calculations were also carried out to provide a deep understanding in geometric, spectroscopic, electronic and nonlinear optical (NLO) properties of complexes 1 and 2. The first‐order hyperpolarizibility (β) parameter calculated as 332.9736 × 10−30 esu demonstrated that complex 1 is an extremely promising candidate to NLO materials. Natural bond orbital (NBO) analysis not only verified the distorted octahedral geometries of central metal ions, but also found out the high‐energy interactions responsible for biological activities for complexes 1 and 2. Anti‐cancer activities of complexes 1 and 2 were tested on human breast carcinoma cell line MCF‐7 (ER and PR positive, HER2 negative) and the triple negative breast carcinoma cell line MDA‐MB 231 (ER, PR and HER2 negative). Dose–response relationship derived from MTT assays indicates that complexes 1 and 2 are showing concentration‐dependent effects, which could suggest a potential use for these drug combinations in cancer cell lines.

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“…Hypochromism typically occurs as a result of the contraction of ctDNA in the helix axis, and this conformation change is often a result of a surface binding complex developing between the small molecules and the DNA, either through external contact or in the case of strong interaction between the small molecules and DNA [62,63]. Classical intercalating compounds are able to couple their π orbital with the π of the base pair of DNA during intercalation into DNA, thereby decreasing the π → π* transition energies [64] and inducing hypochromism combined with a batochromic shift [65]. In contrast, electrostatic interaction can also show hyperchromism, an effect that indicates the increasing likelihood of electrons in the π-π* transition of the extended resonance system.…”

Section: Dna Binding Propertiesmentioning

confidence: 99%

Acridine Based N-Acylhydrazone Derivatives as Potential Anticancer Agents: Synthesis, Characterization and ctDNA/HSA Spectroscopic Binding Properties

et al. 2022

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A series of novel acridine N-acylhydrazone derivatives have been synthesized as potential topoisomerase I/II inhibitors, and their binding (calf thymus DNA—ctDNA and human serum albumin—HSA) and biological activities as potential anticancer agents on proliferation of A549 and CCD-18Co have been evaluated. The acridine-DNA complex 3b (-F) displayed the highest Kb value (Kb = 3.18 × 103 M−1). The HSA-derivatives interactions were studied by fluorescence quenching spectra. This method was used for the calculation of characteristic binding parameters. In the presence of warfarin, the binding constant values were found to decrease (KSV = 2.26 M−1, Kb = 2.54 M−1), suggesting that derivative 3a could bind to HSA at Sudlow site I. The effect of tested derivatives on metabolic activity of A549 cells evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide or MTT assay decreased as follows 3b (-F) > 3a(-H) > 3c(-Cl) > 3d(-Br). The derivatives 3c and 3d in vitro act as potential dual inhibitors of hTopo I and II with a partial effect on the metabolic activity of cancer cells A594. The acridine-benzohydrazides 3a and 3c reduced the clonogenic ability of A549 cells by 72% or 74%, respectively. The general results of the study suggest that the novel compounds show potential for future development as anticancer agents.

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Synthesis, characterization, and DNA-binding of two new Cd(II) complexes with 8-[(2-pyridylmethyl)amino]-quinoline

Cited by 17 publications

References 33 publications

Crystal structure and photoluminescence properties of a new Cd^IIcoordination polymercatena-poly[bis[4-bromo-2-({[2-(pyrrolidin-1-yl)ethyl]imino}methyl)phenolato-κ³N,N′,O]di-μ₃-chlorido-di-μ₂-chlorido-bis(methanol-κO)tricadmium(II)]

Crystal structure and photoluminescence properties of a new Cd^IIcoordination polymercatena-poly[bis[4-bromo-2-({[2-(pyrrolidin-1-yl)ethyl]imino}methyl)phenolato-κ³N,N′,O]di-μ₃-chlorido-di-μ₂-chlorido-bis(methanol-κO)tricadmium(II)]

Synthesis of the first mixed ligand Mn (II) and Cd (II) complexes of 4‐methoxy‐pyridine‐2‐carboxylic acid, molecular docking studies and investigation of their anti‐tumor effects in vitro

Acridine Based N-Acylhydrazone Derivatives as Potential Anticancer Agents: Synthesis, Characterization and ctDNA/HSA Spectroscopic Binding Properties

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Synthesis, characterization, and DNA-binding of two new Cd(II) complexes with 8-[(2-pyridylmethyl)amino]-quinoline

Cited by 17 publications

References 33 publications

Crystal structure and photoluminescence properties of a new CdIIcoordination polymercatena-poly[bis[4-bromo-2-({[2-(pyrrolidin-1-yl)ethyl]imino}methyl)phenolato-κ3N,N′,O]di-μ3-chlorido-di-μ2-chlorido-bis(methanol-κO)tricadmium(II)]

Crystal structure and photoluminescence properties of a new CdIIcoordination polymercatena-poly[bis[4-bromo-2-({[2-(pyrrolidin-1-yl)ethyl]imino}methyl)phenolato-κ3N,N′,O]di-μ3-chlorido-di-μ2-chlorido-bis(methanol-κO)tricadmium(II)]

Synthesis of the first mixed ligand Mn (II) and Cd (II) complexes of 4‐methoxy‐pyridine‐2‐carboxylic acid, molecular docking studies and investigation of their anti‐tumor effects in vitro

Acridine Based N-Acylhydrazone Derivatives as Potential Anticancer Agents: Synthesis, Characterization and ctDNA/HSA Spectroscopic Binding Properties

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Crystal structure and photoluminescence properties of a new Cd^IIcoordination polymercatena-poly[bis[4-bromo-2-({[2-(pyrrolidin-1-yl)ethyl]imino}methyl)phenolato-κ³N,N′,O]di-μ₃-chlorido-di-μ₂-chlorido-bis(methanol-κO)tricadmium(II)]

Crystal structure and photoluminescence properties of a new Cd^IIcoordination polymercatena-poly[bis[4-bromo-2-({[2-(pyrrolidin-1-yl)ethyl]imino}methyl)phenolato-κ³N,N′,O]di-μ₃-chlorido-di-μ₂-chlorido-bis(methanol-κO)tricadmium(II)]