Synthesis, characterization and DNA-binding properties of Ru(II) complexes coordinated by ofloxacin as potential antitumor agents

Wang, Chengxi; Wu, Qiong; Zeng, Yongchang; Huang, Dongwei; Yu, Chuqin; Wang, Xicheng; Mei, Wenjie

doi:10.1080/00958972.2015.1020797

Cited by 20 publications

(3 citation statements)

References 40 publications

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“…New Both techniques suggest an intercalative binding. Our results are in agreement to previous reports on ruthenium(II) bipyridine complexes, indicating that DNA binding behavior is an important aspect of their biological action [68,69]. However, it is also evident that ruthenium(II) complexes bearing different ligands show different cellular distribution [70,71].…”

Section: Discussionsupporting

confidence: 92%

Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation

Baroud

Mihajlović-Lalić

Gligorijević

et al. 2017

Journal of Coordination Chemistry

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Complexes 1-4, [Ru(L)(bpy) 2 ]PF 6 , where bpy = 2,2′-bipyridine; L = 3-methylpyridine-2carboxylic acid (L1), 6-methylpyridine-2-carboxylic acid (L2), 5-bromopyridine-2-carboxylic acid (L3) and 6-bromopyridine-2-carboxylic acid (L4), were synthesized and characterized. The electrochemical character of the complexes was investigated by cyclic voltammetry revealing two reversible reduction waves in the negative range of potentials, most likely due to a reduction of the bipyridine moiety. Cytotoxicity studies by MTT assay for 72 h of drug action revealed that 2-4 exhibited moderate activity in cervical human tumor cells (HeLa). Complex 2 exhibited low activity in colon cancer LS-174 cells (180 ± 10), while all complexes were devoid of activity in lung cancer A549 and non-tumor MRC-5 cells, up to 200 μM. Combinational studies of the most active complex 2, with pharmacological modulators of cell redox status, L-buthioninesulfoximine (L-BSO) or N-acetyl-L-cysteine (NAC), showed that when L-BSO potentiated, 2 induced a sub-G1 peak of the cell cycle in the HeLa cell line. UV-vis and cyclic voltammetry were performed in order to investigate the binding mode of 2 to DNA and suggested intercalation for the complex-DNA interaction.

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Section: Discussionsupporting

confidence: 92%

Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation

Baroud

Mihajlović-Lalić

Gligorijević

et al. 2017

Journal of Coordination Chemistry

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“…Recently, ruthenium(II) complexes have attracted increasing attention in the design of DNA binding and recognition agents as well as anticancer drugs targeting DNA . Some DNA intercalative Ru II complexes have been previously reported to induce DNA B–Z conformational transfer, as well as some Ru II DNA intercalating complexes, which can condense DNA .…”

Section: Introductionmentioning

confidence: 64%

“…[20] Recently,r uthenium(II) complexes have attracted increasing attention in the design of DNA binding and recognition agents [21][22][23][24][25][26][27][28][29][30][31][32] as well as anticancer drugs targeting DNA. [33][34][35][36][37][38] SomeD NA intercalative Ru II complexes have been previously reported to induce DNA B-Z conformational transfer, [39][40][41][42] as well as some Ru II DNA intercalating complexes,w hichc an con-denseD NA. [42][43][44][45][46][47] In this work,o ur results serve to demonstrate the structurale ffect of DNA intercalators on their interference with DNA high-order structures, and to determine the link betweent he B-Z DNA conformational transformation andD NA condensation.…”

Section: Introductionmentioning

confidence: 99%

Interfering with DNA High‐Order Structures using Chiral Ruthenium(II) Complexes

Zou

Rees

et al. 2017

Chemistry A European J

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In this work, it was found that DNA can undergo B-Z transformational changes and compaction in the presence of DNA intercalators such as ruthenium(II) polypyridyl complexes. The link between B-Z transition and condensation is weak but can be strengthened under certain circumstances with slight alterations to the structures of the ruthenium(II) complexes. Here, following on from previous research, this work reports a series of ruthenium(II) complexes with imidazophenanthroline ligands, which vary in size and planarity. The complexes exhibit distinct effects on DNA structures, ranging from little impact to the transformation of DNA secondary structures to the formation of higher-order DNA structures. Further studies on DNA morphological changes induced by chiral ruthenium(II) complexes are observed by atomic force microscopy and transmission electron microscopy.

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Three Arene‐Ru(II) compounds of 2‐halogen‐5‐aminopyridine: Synthesis, characterization, and cytotoxicity

Yan

Xie

Jin

et al. 2017

Applied Organom Chemis

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Three novel compounds, (η6‐p‐cymene)RuCl2(2‐fluoro‐5‐aminopyridine) (compound 1), (η6‐p‐cymene)RuCl2(5‐amino‐2‐chlorpyridine) (compound 2) and (η6‐p‐cymene)RuCl2(2‐bromo‐ 5‐aminopyridine) (compound 3), were synthesized and characterized. The compound 1 and 3 were determined by X‐ray diffraction, showing a distorted piano‐stool type of geometry with similar bond lengths and angles around the ruthenium. Compound 2 exhibited moderate in vitro activity against A549 and MCF‐7 human cancer cells, the other two lower activities. The UV–vis and fluorescent absorption titrations showed that three compounds binded with CT‐DNA in a minor groove. The intrinsic binding constants (Kb) were calculated to be 2.13(±0.03) × 105 M−1, 2.89(±0.03) × 105 M−1 and 2.45(±0.03) × 105 M−1 for compound 1, 2 and 3, respectively, by using UV–vis absorption titrations data. Among the three compound, the highest value of intrinsic binding constant of compound 2 was consistent with its highest cytoxicity against A549 and MCF‐7 human cancer cells in vitro.

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Synthesis, characterization and DNA-binding properties of Ru(II) complexes coordinated by ofloxacin as potential antitumor agents

Cited by 20 publications

References 40 publications

Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation

Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation

Interfering with DNA High‐Order Structures using Chiral Ruthenium(II) Complexes

Three Arene‐Ru(II) compounds of 2‐halogen‐5‐aminopyridine: Synthesis, characterization, and cytotoxicity

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