Synthesis, characterization and DNA interactions of 5,15-(4-pyridyl)-10,20-(pentafluorophenyl)porphyrin coordinated to two [Ru(bipy)2Cl]+ groups

Narra, Muralikrishna; Elliott, Patrick; Swavey, Shawn

doi:10.1016/j.ica.2005.12.073

Cited by 47 publications

(25 citation statements)

References 28 publications

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“…The studies on the binding of Ru(II) complexes with DNA have become prominent recently, investigating the binding mode either reversible or non-covalent. Numerous reports have been published on the DNA binding of metal complexes with bipyridyl ligands (Kumar et al 2010;Narra et al 2006;Xiong & Ji 1999) and significant effect on the spectral and DNA binding behaviour of the complexes were observed through varying the ancillary ligands of metal complexes (Liu et al 2001;Xu et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and DNA Binding Studies of [Ruthenium(II)(bpy)2L]2+ where L are Derivatives of imidazo[4,5-f]-1,10-phenanthrolines

Ting¹,

Crouse²,

Ahmad³

2015

JSM

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Three novel ruthenium(II) complexes of the general formula [Ru(II)(bpy) 2 L]2+ were synthesized, where L = 1,10-phenanthroline derivatives of position 2 imidazole having 3,4-didecyloxy-phenyl (ddip), 3,4-ditetradecyloxy-phenyl (dtip) and 3,4-dihexadecyloxy-phenyl (dhip Tiga rutenium (II) kompleks baharu, [Ru(II)(bpy) 2 L] 2 + dengan L = 1,10 derivatif-fenantrolina daripada imidazola mempunyai 3,4-didesiloksifenil (L10), 3,4-ditetradesiloksi-fenil (L14) dan 3,4-diheksadisiloksi-fenil (L16) pada kedudukan 2 telah disintesis. Semua kompleks telah dicirikan oleh analisis unsur, spekstroskopi resonans magnet nukleus dan ESI-MS

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Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and DNA Binding Studies of [Ruthenium(II)(bpy)2L]2+ where L are Derivatives of imidazo[4,5-f]-1,10-phenanthrolines

Ting¹,

Crouse²,

Ahmad³

2015

JSM

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“…Fluorinated porphyrins have been studied due to their effective energy absorption and greater triplet quantum yields. [11] This report describes the synthesis and characterization, by 1 H NMR spectroscopy, elemental analysis, UV/Vis spectroscopy and cyclic voltammetry of a new complex, which incorporates ruthenium(II)-polypyridyl moieties with a pentafluorophenyl-substituted porphyrin (I).…”

Section: Introductionmentioning

confidence: 99%

Highly Efficient Visible‐Light‐Induced Photocleavage of DNA by a Ruthenium‐Substituted Fluorinated Porphyrin

et al. 2009

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A new porphyrin, meso-5-(pentafluorophenyl)-10,15,20-tris(4-pyridyl)porphyrin, has been synthesized. Coordination of two [Ru(bipy) 2 Cl] + moieties (where bipy = 2,2Ј-bipyridine) to the pyridyl nitrogen atoms in the 10,15-positions gives the target complex. Electronic transitions associated with the ruthenium-porphyrin include an intense Soret band and four less intense Q-bands in the visible region of the spectrum. An intense π-π* transition in the UV region associated with the bipyridyl groups and a metal-to-ligand charge-transfer (MLCT) band appearing as a shoulder to the Soret band are also observed. Electrochemical properties associated with the complex include a redox couple in the cathodic region with E 1/2 =

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“…In a recent study the detection of interaction of the metallated porphyrin with circular plasmid DNA was performed by using cyclic voltammetry and spectroelectrochemistry, and the levels of DNA damage induced by irradiation in linearized PUC18 cells were confirmed by gel electrophoresis [24].…”

Section: Introductionmentioning

confidence: 99%

The Comparison of Electrochemical Assay and Agarose Gel Electrophoresis for the Determination of DNA Damage Induced by Kainic Acid

et al. 2009

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A possible DNA damage after interaction of kainic acid (KA) with calf thymus double stranded DNA and genomic DNA was herein determined in in vitro and in vivo conditions using; electrochemical assay and agarose gel electrophoresis. The changes in guanine signal were detected as an indicator of DNA damage in genomic DNA samples isolated from 1 or 10 mg/kg KA-treated animals. The decreased levels of guanine signal were found as 29% and 33% by 1 and 10 mg/kg KA treatment when compared to controls, respectively. The results of gel electrophoresis confirmed DNA damage obtained in identical samples by electrochemical method.

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Synthesis, characterization and DNA interactions of 5,15-(4-pyridyl)-10,20-(pentafluorophenyl)porphyrin coordinated to two [Ru(bipy)2Cl]+ groups

Cited by 47 publications

References 28 publications

Synthesis, Characterization and DNA Binding Studies of [Ruthenium(II)(bpy)2L]2+ where L are Derivatives of imidazo[4,5-f]-1,10-phenanthrolines

Synthesis, Characterization and DNA Binding Studies of [Ruthenium(II)(bpy)2L]2+ where L are Derivatives of imidazo[4,5-f]-1,10-phenanthrolines

Highly Efficient Visible‐Light‐Induced Photocleavage of DNA by a Ruthenium‐Substituted Fluorinated Porphyrin

The Comparison of Electrochemical Assay and Agarose Gel Electrophoresis for the Determination of DNA Damage Induced by Kainic Acid

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