Synthesis, Characterization and Docking Studies of Some Novel Dihydropyridine Derivatives

Abstract

The synthesis of a novel dihydropyridine derivatives bearing dimedone as an excellent precursor has been achieved by applying three component Hantzsch condensation. The newly synthesized compounds were characterized by IR, NMR, Mass spectra and also by Elemental analyses. All synthesized compounds undergo docking studies and biological screening for antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and fungal species. Among all the tested compounds, it was found that compound 3d, 3e, 3g and 3i revealed better activities against the Gram-positive rather than the Gram-negative bacteria whereas compounds 3c, 3d, 3e, 3g and 3i showed best docking score in docking studies.

Polyamidation of new diamine monomers containing bulky pendant groups based on imidazole ring and fabrication of polyamide/modified‐SiO2composite: Properties and applications

“…One of the effective factors to reduce antibacterial inhibition is the existence of electron donor groups in the structure of compounds. 44 Moreover, as the data in Table 4 show, among the relevant synthesized polymers, PAs derived from dipicolinic acid (PA-aIII and PA-bIII) have more antimicrobial activity compared to other PAs, may be related to the presence of electronwithdrawing pyridine, 45 also PAs containing (-OMe) groups indicated a less antimicrobial activity than PAs containing benzil segment. Generally, NPs when interacting with the surface of bacterial and fungal, and with entering to inside the cell causing its destruction.…”