Synthesis, characterization and electrochemical studies of titanium oxide nanoparticle modified carbon paste electrode for the determination of paracetamol in presence of adrenaline

Manjunatha, K.; Swamy, B.E. Kumara; Madhuchandra, H.D.; Vishnumurthy, K.A.

doi:10.1016/j.cdc.2020.100604

Cited by 29 publications

(27 citation statements)

References 33 publications

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“…Clearly, there is no significant difference between the β-CDmodified and activated GCE in the electrochemical sensing of acetaminophen. These sensing parameters compare reasonably well, with a number of previous investigations, where multiwalled carbon nanotubes (MWCNTs) [49], graphene [9] and various nanoparticles (NPs) [50], and other electrode modifications, such as bismuth [51], were used. While the linear region is somewhat lower than some of the reported values (Table S1 (supplementary data)) that have linear ranges extending from 5 to 200 μM [49], the sensitivities are high at 32.7 and 34.4 μA cm -2 μM -1 .…”

Section: Sensing Performance Of the Modified Gce Electrodessupporting

confidence: 81%

Electrochemical determination of acetaminophen at a carbon electrode modified in the presence of β-cyclodextrin: role of the activated glassy carbon and the electropolymerised β-cyclodextrin

Healy

Rizzuto

Rose

et al. 2021

J Solid State Electrochem

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Acetaminophen is a well-known drug commonly used to provide pain relief, but it can also lead to acute liver failure at high concentrations. Therefore, there is considerable interest in monitoring its concentrations. Sensitive and selective acetaminophen electrochemical sensors were designed by cycling a glassy carbon electrode (GCE) to high potentials in the presence of β-CD in a phosphate electrolyte, or by simply activating the GCE electrode in the phosphate solution. Using cyclic voltammetry, adsorption-like voltammograms were recorded. The acetaminophen oxidation product, N-acetyl benzoquinone imine, was protected from hydrolysis, and this was attributed to the adsorption of acetaminophen at the modified GCE. The rate constants for the oxidation of acetaminophen were estimated as 4.3 × 10–3 cm2 s–1 and 3.4 × 10–3 cm2 s–1 for the β-CD-modified and -activated electrodes, respectively. Using differential pulse voltammetry, the limit of detection was calculated as 9.7 × 10–8 M with a linear concentration range extending from 0.1 to 80 μM. Furthermore, good selectivity was achieved in the presence of caffeine, ascorbic acid and aspirin, enabling the determination of acetaminophen in a commercial tablet. Similar electrochemical data were obtained for both the β-CD-modified and activated GCE surfaces, suggesting that the enhanced detection of acetaminophen is connected mainly to the activation and oxidation of the GCE. Using SEM, EDX and FTIR, no evidence was obtained to indicate that the β-CD was electropolymerised at the GCE.

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Section: Sensing Performance Of the Modified Gce Electrodessupporting

confidence: 81%

Electrochemical determination of acetaminophen at a carbon electrode modified in the presence of β-cyclodextrin: role of the activated glassy carbon and the electropolymerised β-cyclodextrin

Healy

Rizzuto

Rose

et al. 2021

J Solid State Electrochem

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“…where M is the slope of the calibration graph and S is the standard deviation of the six blank measurements. The calculated LOD for PA was 0.21 µM, which is lower than most of the previous reports, as shown in Table 3 [51][52][53][54][55][56][57][58][59][60][61][62][63]. The pH of the electrolyte has a major role on the electro-oxidation of organic molecules and can be easily evaluated by recording the CV of the analyte with varying electrolyte pH.…”

Section: The Varying Concentration Effectmentioning

confidence: 78%

Quantum Chemical Studies and Electrochemical Investigations of Polymerized Brilliant Blue-Modified Carbon Paste Electrode for In Vitro Sensing of Pharmaceutical Samples

et al. 2021

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To develop an electrochemical sensor for electroactive molecules, the choice and prediction of redox reactive sites of the modifier play a critical role in establishing the sensing mediating mechanism. Therefore, to understand the mediating mechanism of the modifier, we used advanced density functional theory (DFT)-based quantum chemical modeling. A carbon paste electrode (CPE) was modified with electropolymerization of brilliant blue, later employed for the detection of paracetamol (PA) and folic acid (FA). PA is an analgesic, anti-inflammatory and antipyretic prescription commonly used in medical fields, and overdose or prolonged use may harm the liver and kidney. The deficiency of FA associated with neural tube defects (NTDs) and therefore the quantification of FA are very essential to prevent the problems associated with congenital deformities of the spinal column, skull and brain of the fetus in pregnant women. Hence, an electrochemical sensor based on a polymerized brilliant blue-modified carbon paste working electrode (BRB/CPE) was fabricated for the quantification of PA and FA in physiological pH. The real analytical applicability of the proposed sensor was judged by employing it in analysis of a pharmaceutical sample, and good recovery results were obtained. The potential excipients do not have a significant contribution to the electro-oxidation of PA at BRB/CPE, which makes it a promising electrochemical sensing platform. The real analytical applicability of the proposed method is valid for pharmaceutical analysis in the presence of possible excipients. The prediction of redox reactive sites of the modifier by advanced quantum chemical modeling-based DFT may lay a new foundation for researchers to establish the modifier–analyte interaction mechanisms.

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“…Some researchers use cobalt complexes [20] or cobalt oxide [21] to detect RA with detection limits between 0.05 and 0.37 μmol/L. In addition, titanium oxide [22], cobalt-copper oxide [23], zirconium oxide [24], iron oxide [25] and lanthanum oxide [15] with limits of detection of PCM between 5.2 and 0.009 μmol/L have been used. These reports describe simpler electrodes with equally acceptable detection limits.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Electrochemical Determination of Paracetamol and Allura Red in Pharmaceutical Doses and Food Using a Mo(VI) Oxide‐Carbon Paste Microcomposite

et al. 2021

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This work presents a new application for MoO 3 combined with carbon paste to prepare a microcomposite electrode (Mo(VI) Ox /CPE) for the simultaneous determination of paracetamol (PCM) and Allure Red (AR) by square-wave voltammetry (SWV). The anodic peak currents for PCM and AR were 70.0 and 80.0 % high compared with an unmodified carbon paste electrode.The surface areas of Mo(VI) Ox /CPE and CPE were evaluated by cyclic voltammetry. The detection limit were 0.14 and 0.38 μmol/L for PCM and AR respectively. The relative standard deviations (RSDs) were 2.0 % (n = 7). Stability, shelf life and possible interferences were also evaluated with very acceptable results.

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Synthesis, characterization and electrochemical studies of titanium oxide nanoparticle modified carbon paste electrode for the determination of paracetamol in presence of adrenaline

Cited by 29 publications

References 33 publications

Electrochemical determination of acetaminophen at a carbon electrode modified in the presence of β-cyclodextrin: role of the activated glassy carbon and the electropolymerised β-cyclodextrin

Electrochemical determination of acetaminophen at a carbon electrode modified in the presence of β-cyclodextrin: role of the activated glassy carbon and the electropolymerised β-cyclodextrin

Quantum Chemical Studies and Electrochemical Investigations of Polymerized Brilliant Blue-Modified Carbon Paste Electrode for In Vitro Sensing of Pharmaceutical Samples

Simultaneous Electrochemical Determination of Paracetamol and Allura Red in Pharmaceutical Doses and Food Using a Mo(VI) Oxide‐Carbon Paste Microcomposite

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