Synthesis, Characterization, and Evaluation of Antimicrobial and Antifertility Efficacy of Heterobimetallic Complexes of Copper (II)

Abstract

Heterobimetallic complexes of the copper with remarkable antimicrobial and antifertility action have been synthesized by the conventional method by reacting CuCl 2 and o-phenylenediamine in the methanolic medium forming the mononuclear complex of the type [Cu(C 6 H 8 N 2 ) 2 ]Cl 2 which was further treated with group 4 or 14 organometallic dichlorides (Ph 2 M Cl 2 , Me 2 M Cl 2 , and Cp 2 M Cl 2 ) [M = Sn, Si, and M = Ti, Zr] leading to formation of heterobimetallic complexes. All the synthesized complexes were characterized in the light of various physicochemical techniques like elemental analyses, conductivity measurements, molecular weight determination, electronic and infrared spectra, electronic spin resonance, X-ray, and mass spectral studies. The in vitro antibacterial activity of synthesized complexes against Escherichia coli and Staphylococcus aureus was tested to evaluate their inhibiting activities. The antifungal activities of mono-and heterobimetallic complexes were studied by screening the compounds against Fusarium oxysporum and Alternaria alternata. These complexes were then investigated to reveal their effect on the reproductive organs of male rats. The treatment has shown substantial decline in the sperm motility and density signifying the imperious antifertility activity.

Preparation, spectroscopic analysis, and biological assessment of heteroleptic Zr(II) and Pd(II) complexes from Otc/Sal mixed ligands

“…Similarly, the strong absorption bands with stretching vibration of the carbonyl (C=O) groupwere seen at 1614 cm -1 and 1622 cm -1 regions in the spectrum [32,33]. The aromatic υ(C=C) absorption bands are at 1502 cm -1 and 1455 cm -1 respectively [34]. The complexes at (1456 and 1387) cm -1 are due to a characteristic band υ(C-N); this band denotes the carbon-nitrogen bond order intermediate between a single bond.…”

Synthesis, characterization, antimicrobial and in vitro cytotoxic evaluation of trinuclear heterobimetallic complexes of Ni (II) derived by the reaction of [Ni(C10H10N2)2]Cl2 with dialkyl/diaryl organometallic dichlorides

“…Along with the removal of HCl molecules, nitrogen undergoes deprotonation and forms bonds with other metal ions of Group 4 or 14. 42 The bands at 2,999 and 1,431 cm À1 , which correspond to the ν(C-H) and ν(C-C) vibrations, respectively, and the stretching vibrations at 1,018 and 812 cm À1 show that the cyclopentadienyl ring exists in some trinuclear heterobimetallic complexes. Furthermore, appearance of bands due to the (Ti-C 5 H 5 ) and (Zr-C 5 H 5 ) appeared at 444 and 442 cm À1 , respectively.…”

“…The treatment has significantly reduced sperm density and motility, which indicates severe antifertility action. 42 A series of biologically effective trinuclear heterobimetallic complexes derived by 2,6-diaminopyridine was investigated and characterized by various spectroscopic techniques. The in vitro antimicrobial evaluation was performed out against a number of microorganisms, and cytotoxicity evaluation was carried out against human cell lines.…”

Synthesis, Characterization, and Biological Evaluation of Unimetallic and Heterobimetallic Complexes of Bivalent Copper

“…The biomedical inorganic chemistry has been a captivating research area due to extensive applications of inorganic pharmaceuticals in innumerable clinical therapy and diagnosis [ 2 ]. Transition metal complexes have received much attention because of their biological activities, including antiviral [ 3 ], anticarcinogenic [ 4 ], antifertility [ 5 ], antibacterial [ 6 ], and antifungal activities [ 7 ].…”