Synthesis, characterization, and evaluation of PEGylated first-row transition metal ferrite nanoparticles as T<sub>2</sub>contrast agents for high-field MRI

Banerjee, Abhinandan; Błasiak, Barbara; Pasquier, Eva; Tomanek, Bogusław; Trudel, Simon

doi:10.1039/c7ra05495e

Cited by 48 publications

(28 citation statements)

References 63 publications

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“…Liquid uncured PEGDA contained characteristic acrylate peaks at ∼1636 cm −1 and ∼1618 cm −1 (C=C stretching) [ 54 ], which was difficult to identify in A1-A4 formulations after photopolymerization, due to conversion of C=C to C–C bonds [ 16 , 55 ]. The PEGDA showed characteristic C=O symmetric stretching absorption band at 1731 cm −1 in all ATH formulations [ 56 ], while peaks characteristic for the PEG 400 were at ~1096 cm −1 (C–O–C ether stretching) and at ~2867 cm −1 corresponding to –C–H symmetric and asymmetric stretching vibrations [ 57 ]. Prominent peaks from ATH observed in tablets were at ~1242 and ~1009 cm −1 indicating ArO-R stretching and R-NH stretching [ 58 ].…”

Section: Resultsmentioning

confidence: 99%

Digital Light Processing (DLP) 3D Printing of Atomoxetine Hydrochloride Tablets Using Photoreactive Suspensions

et al. 2020

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Three-dimensional (3D) printing technologies are based on successive material printing layer-by-layer and are considered suitable for the production of dosage forms customized for a patient’s needs. In this study, tablets of atomoxetine hydrochloride (ATH) have been successfully fabricated by a digital light processing (DLP) 3D printing technology. Initial materials were photoreactive suspensions, composed of poly(ethylene glycol) diacrylate 700 (PEGDA 700), poly(ethylene glycol) 400 (PEG 400), photoinitiator and suspended ATH. The amount of ATH was varied from 10.00 to 25.00% (w/w), and a range of doses from 12.21 to 40.07 mg has been achieved, indicating the possibility of personalized therapy. The rheological characteristics of all photoreactive suspensions were appropriate for the printing process, while the amount of the suspended particles in the photoreactive suspensions had an impact on the 3D printing process, as well as on mechanical and biopharmaceutical characteristics of tablets. Only the formulation with the highest content of ATH had significantly different tensile strength compared to other formulations. All tablets showed sustained drug release during at least the 8h. ATH crystals were observed with polarized light microscopy of photoreactive suspensions and the cross-sections of the tablets, while no interactions between ATH and polymers were detected by FT-IR spectroscopy.

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Section: Resultsmentioning

confidence: 99%

Digital Light Processing (DLP) 3D Printing of Atomoxetine Hydrochloride Tablets Using Photoreactive Suspensions

et al. 2020

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“…PEG 400 showed characteristic peaks at 3445 cm −1 (O-H stretching), 2866 cm −1 (C-H stretching) and 1096 cm −1 (C-O-C ether stretching) [ 41 ]. Peaks at 2866 cm −1 and 1096 cm −1 are also present in the spectra of the printed tablets.…”

Section: Resultsmentioning

confidence: 99%

“…The spectrum of uncured PEGDA had characteristic peaks at 2866 cm −1 (CH3 stretching), 1721 cm −1 (C=O stretching) and 1636 cm −1 (acrylate C=C stretching) [ 27 , 42 ]. After the photopolymerization process, it was not possible to identify the acrylate-related peaks at 1636 cm −1 , due to the conversion of C=C to C-C bonds [ 41 ]. The major peaks identified in the pure ATH spectra were clearly observed in the spectra of all fabricated tablets, which indicates the absence of interactions between drug and polymers.…”

Section: Resultsmentioning

confidence: 99%

Tailoring Atomoxetine Release Rate from DLP 3D-Printed Tablets Using Artificial Neural Networks: Influence of Tablet Thickness and Drug Loading

et al. 2020

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Various three-dimensional printing (3DP) technologies have been investigated so far in relation to their potential to produce customizable medicines and medical devices. The aim of this study was to examine the possibility of tailoring drug release rates from immediate to prolonged release by varying the tablet thickness and the drug loading, as well as to develop artificial neural network (ANN) predictive models for atomoxetine (ATH) release rate from DLP 3D-printed tablets. Photoreactive mixtures were comprised of poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) 400 in a constant ratio of 3:1, water, photoinitiator and ATH as a model drug whose content was varied from 5% to 20% (w/w). Designed 3D models of cylindrical shape tablets were of constant diameter, but different thickness. A series of tablets with doses ranging from 2.06 mg to 37.48 mg, exhibiting immediate- and modified-release profiles were successfully fabricated, confirming the potential of this technology in manufacturing dosage forms on demand, with the possibility to adjust the dose and release behavior by varying drug loading and dimensions of tablets. DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction) and microscopic analysis showed that ATH remained in a crystalline form in tablets, while FTIR spectroscopy confirmed that no interactions occurred between ATH and polymers.

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“…The hydrophilicity of colloids allows proximity of more water molecules to nanoparticles that ultimately affect the relaxivity. The nature of coatings (hydrophobic or hydrophilic) on nanoparticles strongly effect hydration degree to enhance their MRI imaging ability [41]. It was perceived that with an increase in the concentration of iron from lower to higher values, signal intensity decreases [23].…”

Section: Mri Diagnostics Via Contrast Enhancementmentioning

confidence: 99%

Aminodextran Coated CoFe2O4 Nanoparticles for Combined Magnetic Resonance Imaging and Hyperthermia

et al. 2020

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Aminodextran (AMD) coated magnetic cobalt ferrite nanoparticles are synthesized via electrostatic adsorption of aminodextran onto magnetic nanoparticles and their potential theranostic application is evaluated. The uncoated and aminodextran-coated nanoparticles are characterized to determine their hydrodynamic size, morphology, chemical composition, zeta potential and magnetization. The aminodextran containing cobalt ferrite nanoparticles of nanometer size are positively charged in the pH range from 3 to 9 and exhibit saturation magnetization of 50 emu/g. The magnetic resonance imaging (MRI) indicates capability for diagnostics and a reduction in intensity with an increase in nanoparticle amount. The hyperthermia capability of the prepared particles shows their potential to generate suitable local heat for therapeutic purposes. There is a rise of 7 °C and 9 °C at 327 kHz and 981 kHz respectively and specific absorption rates (SAR) of aminodextran-coated nanoparticles are calculated to be 259 W/g and 518 W/g at the given frequencies larger than uncoated nanoparticles (0.02 W/g). The development of novel aminodextran coated magnetic cobalt ferrite nanoparticles has significant potential to enable and improve personalized therapy regimens, targeted cancer therapies and ultimately to overcome the prevalence of nonessential and overdosing of healthy tissues and organs.

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Synthesis, characterization, and evaluation of PEGylated first-row transition metal ferrite nanoparticles as T₂contrast agents for high-field MRI

Cited by 48 publications

References 63 publications

Digital Light Processing (DLP) 3D Printing of Atomoxetine Hydrochloride Tablets Using Photoreactive Suspensions

Digital Light Processing (DLP) 3D Printing of Atomoxetine Hydrochloride Tablets Using Photoreactive Suspensions

Tailoring Atomoxetine Release Rate from DLP 3D-Printed Tablets Using Artificial Neural Networks: Influence of Tablet Thickness and Drug Loading

Aminodextran Coated CoFe2O4 Nanoparticles for Combined Magnetic Resonance Imaging and Hyperthermia

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Synthesis, characterization, and evaluation of PEGylated first-row transition metal ferrite nanoparticles as T2contrast agents for high-field MRI

Cited by 48 publications

References 63 publications

Digital Light Processing (DLP) 3D Printing of Atomoxetine Hydrochloride Tablets Using Photoreactive Suspensions

Digital Light Processing (DLP) 3D Printing of Atomoxetine Hydrochloride Tablets Using Photoreactive Suspensions

Tailoring Atomoxetine Release Rate from DLP 3D-Printed Tablets Using Artificial Neural Networks: Influence of Tablet Thickness and Drug Loading

Aminodextran Coated CoFe2O4 Nanoparticles for Combined Magnetic Resonance Imaging and Hyperthermia

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Synthesis, characterization, and evaluation of PEGylated first-row transition metal ferrite nanoparticles as T₂contrast agents for high-field MRI