Synthesis, Characterization and Evaluation of Biological Activity of some Substituted(<i>E</i>)<i>-</i>2-Benzylidenehydrazinecarbothio Amides

Abstract

A series of substituted (E)-2-benzylidenehydrazinecarbothioamide compounds were synthesized by condensation of thiosemicarbazide with substituted benzaldehydes. The synthesized substituted (E)-2-benzylidenehydrazinecarbothioamide compounds were characterized by their physical constants, UV, IR and NMR spectra. The antimicrobial activities of these synthesized substituted (E)-2-benzylidenehydrazinecarbothioamide compounds have been screened by Bauer-Kirby method using human pathogenic bacteria and fungal species. The antimicrobial activities of all synthesized (E)-2-benzylidenehydrazinecarbothioamide compounds have shown significant activity.