Synthesis, Characterization and Evaluation of Antimicrobial and Antituberculosis Activities of New <i>N</i>‐(Substituted‐thioureido)aminobicyclo Dicarboximide and 3,4‐Disubstituted 1,2,4‐Triazolino‐5‐thione

Pachuta‐Stec, Anna; Kosikowska, Urszula; Mazur, Liliana; Swatko-Ossor, Marta; Pitucha, Monika; Malm, Anna; Ginalskad, Grażyna

doi:10.1002/jccs.201300362

Cited by 5 publications

(1 citation statement)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pachuta‐Stec et al prepared novel N ‐(substituted‐thioureido)aminobicyclo dicarboximide and 3,4‐disubstituted 1,2,4‐triazolino‐5‐thione (Figure ) and examined their antituberculosis activity by broth dilution method. Among the synthesized derivatives, only compounds 82 and 83 exhibited moderate activity against the tested mycobacteria with MIC value 256–512 μg/mL.…”

Section: Pharmacological Applications Of 124‐triazolementioning

confidence: 99%

Exploring recent developments on 1,2,4‐triazole: Synthesis and biological applications

Sathyanarayana

Poojary

2020

J Chinese Chemical Soc

View full text Add to dashboard Cite

Triazoles are nitrogen-bearing heterocycles. In the last few decades, researchers have focused on fused heterocycles, as they have better pharmacological effect compared to triazoles alone. Among the two isomers of triazole, this article aims to explore the work carried out on 1,2,4-triazole and N-bridged heterocycles derived from 1,2,4-triazole in last 18 years, highlight different synthetic pathways, and present a brief summary of the different biological activities possessed by 1,2,4-triazole derivatives. The information collected in this article is expected to help researchers to discover novel therapeutic agents for better applications in the field of pharmaceutical science. K E Y W O R D Sbio-organic chemistry, medicinal chemistry, organic chemistry

show abstract

Section: Pharmacological Applications Of 124‐triazolementioning

confidence: 99%

Exploring recent developments on 1,2,4‐triazole: Synthesis and biological applications

Sathyanarayana

Poojary

2020

J Chinese Chemical Soc

View full text Add to dashboard Cite

show abstract

Synthesis of 5‐Cyano‐2‐Carbethoxythieno[2,3‐b]thiophenyl‐3,4‐Diisothiocyanates and Its Utility IN Heterocyclic Synthesis under Phase Transfer Catalytic Technique

Allah

2015

J Chinese Chemical Soc

View full text Add to dashboard Cite

Regarding to the importance of thieno[2,3‐b]thiophens and isothiocyanaetes reactiveties in the physical, chemical and pharmaceutical fields, this study has been undertaken to prepare the target compound 5‐cyano‐2‐carbethoxythieno[2,3‐b]thiophenyl‐3,4‐diisothiocyanates via a safe method. The formed isothiocyanates derivative was reacted with aromatic amines, acid hydrazied and some active methylene groups, followed by cyclization reaction for the formed intermediates to give new series of heterocyclic compounds

show abstract

Experimental and computational studies of tautomerism pyridine carbonyl thiosemicarbazide derivatives

et al. 2023

View full text Add to dashboard Cite

Tautomerism is one of the most important phenomena to consider when designing biologically active molecules. In this work, we use NMR spectroscopy, IR, and X-ray analysis as well as quantum-chemical calculations in the gas phase and in a solvent to study tautomerism of 1- (2-, 3- and 4-pyridinecarbonyl)-4-substituted thiosemicarbazide derivatives. The tautomer containing both carbonyl and thione groups turned out to be the most stable. The results of the calculations are consistent with the experimental data obtained from NMR and IR spectroscopy and with the crystalline forms from the X-ray studies. The obtained results broaden the knowledge in the field of structural studies of the thiosemicarbazide scaffold, which will translate into an understanding of the interactions of compounds with a potential molecular target.

show abstract

Synthesis, Characterization and Evaluation of Antimicrobial and Antituberculosis Activities of New N‐(Substituted‐thioureido)aminobicyclo Dicarboximide and 3,4‐Disubstituted 1,2,4‐Triazolino‐5‐thione

Cited by 5 publications

References 38 publications

Exploring recent developments on 1,2,4‐triazole: Synthesis and biological applications

Exploring recent developments on 1,2,4‐triazole: Synthesis and biological applications

Synthesis of 5‐Cyano‐2‐Carbethoxythieno[2,3‐b]thiophenyl‐3,4‐Diisothiocyanates and Its Utility IN Heterocyclic Synthesis under Phase Transfer Catalytic Technique

Experimental and computational studies of tautomerism pyridine carbonyl thiosemicarbazide derivatives

Contact Info

Product

Resources

About