Synthesis, characterization and in vitro biological evaluation of [Ru(η6-arene)(N,N)Cl]PF6 compounds using the natural products arenes methylisoeugenol and anethole

Ruthenium–arene complexes with NSAIDs: synthesis, characterization and bioactivity

“…7 Also, ruthenium can mimic iron in binding with certain biological molecules, particularly transferrin, and Ru(II) and Ru(III) complexes can display similar ligand exchange kinetics to Pt(II). 8 Considering all these characteristics, ruthenium complexes are suitable for medical applications. Three of these, namely KP1339, KP1019 and NAMI, have entered clinical trials, with promising results.…”

“…11 Because the concentration of oxygen in tumor cells is low, the environment is more reductive than in normal tissue, favouring the active reduced form. 8,12 A real revolution in medicine occurred with the discovery of non-steroidal anti-inflammatory drugs (NSAIDs), which have been proven to be biologically active compounds. NSAIDs are one of the most commonly used classes of medication.…”

η6-(2-phenoxyethanol) ruthenium(II)-complexes of 2,2′-bipyridine and its derivatives: Solution speciation and kinetic behaviour

“…RM-complexes possess the bidentate ethylenediamine as non-leaving group and one chlorido ligand prompt for aquation [13]. The importance as potential anticancer agents of compounds of general formula [Ru II (η 6 -arene)(N,N)Cl] + lead to extensive studies comprising the variation of the arene group and the (N,N) bidentate ligand [14][15][16][17][18][19]20]. In these studies the η 6 was tested [14][15][16][17][18][19]20].…”

“…The importance as potential anticancer agents of compounds of general formula [Ru II (η 6 -arene)(N,N)Cl] + lead to extensive studies comprising the variation of the arene group and the (N,N) bidentate ligand [14][15][16][17][18][19]20]. In these studies the η 6 was tested [14][15][16][17][18][19]20]. The mechanism of action for the generality of compounds from this family has been related as expected, to the lability of the chlorido ligand due to its hydrolysis in aqueous environment [20][21][22].…”

Oxaliplatin Analogues with Carboxy Derivatives of Boldine with Enhanced Antioxidant Activity

“…To explore the potential pharmacological synergism between metal-based drugs and natural products, our research group has focused on the synthesis of these types of compounds employing natural derivatives as ligands [ 19 , 20 ]. Boldine (L1) is the main constituent of the endemic Chilean boldo tree ( Peumus boldus Molina, Monimiaceae) and possesses important health-promoting properties, such as antioxidant, anti-inflammatory, and cytoprotective effects [ 21 ].…”