Synthesis, characterization and in vitro drug release of magnetic N-benzyl-O-carboxymethylchitosan nanoparticles loaded with indomethacin

Debrassi, Aline; Bürger, Cristiani; Rodrigues, Clóvis Antônio; Nedelko, N.; Ślawska‐Waniewska, A.; Dłużewski, Piotr; Sobczak, Kamil; Grenèche, Jean‐Marc

doi:10.1016/j.actbio.2011.05.001

Cited by 40 publications

(14 citation statements)

References 31 publications

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“…Recognition of these effects led to propose the use of porous substrates to design magnetic carriers for drug delivery to specific sites within the body [16,17]. In this sense, Debrassi et al [18] have recently reported advancements about magnetic materials synthesis for the controlled release of indomethacin. They obtained materials with high drug loading efficiency and adequate magnetic properties.…”

Section: Introductionmentioning

confidence: 99%

Development of iron modified MCM-41 as promising nano-composites with specific magnetic behavior

Cuello

Elías

Torres

et al. 2015

Microporous and Mesoporous Materials

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Section: Introductionmentioning

confidence: 99%

Development of iron modified MCM-41 as promising nano-composites with specific magnetic behavior

Cuello

Elías

Torres

et al. 2015

Microporous and Mesoporous Materials

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“…Very importantly, the peak change around 567 cm −1 signals the Fe–O deformation in octahedral and tetrahedral sites and is the distinctive peak for Fe 3 O 4 magnetic NPs [11, 16]. Additionally, a weak band at 792 and 891 cm −1 could also be due to the Fe–O bonds of Fe 3 O 4 [17, 18]. To understand the adsorption mechanism, an FTIR of adsorbed sample was also examined and the change in wavenumber for most of the peak is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Functional group‐assisted green synthesised superparamagnetic nanoparticles for the rapid removal of hexavalent chromium from aqueous solution

Nithya

Sathish

Kumar³

et al. 2017

IET nanobiotechnol.

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Superparamagnetic nanoparticles (NPs) prepared using the capping agent derived from the Lantana camara fruit extract were used to study the adsorption of chromium ions. Characterisation techniques such as scanning electron microscope, energy-dispersive X-ray, Fourier transform infrared spectroscopy, X-ray diffraction, vibrating sample magnetometer and thermo gravimetric analysis (TGA) were used to study the NP features and adsorption mechanisms. The maximum monolayer adsorption capacity calculated from the Langmuir isotherm was found to be 41 mg/g. The chemical nature of the adsorption is confirmed with the results of Dubinin-Radushkevich model and thermodynamic studies. In addition, thermodynamically favourable and spontaneous adsorption is considered to be a good indication for the removal of metal ions. Out of the kinetic models investigated, the experiments exhibited the best fit to pseudo-second-order model, advocating for surface-based adsorption, involving both physical and chemical interactions. It is also significant to note that 85% of the adsorption occurs in the first 10 min, and hence the selected adsorbent is also claimed for rapid removal of metal ions. The newly synthesised adsorbent hence possesses remarkable properties in terms of simple synthesising technique, low cost, rapid uptake and improved efficiency without generating harmful byproducts.

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“…The study established the potential use of chitosan coated alginate-NOCM-chitosan hydrogel as polymeric carrier for colon specific delivery of sulfasalazine. The nonsteroidal anti-inflammatory drug indomethacin has been prepared in magnetic N-benzyl-OCM-chitosan nanoparticles (Debrassi et al, 2011).…”

Section: Carboxymethyl Chitosan Based Systems For the Delivery Of Antmentioning

confidence: 99%

Biomedical applications of carboxymethyl chitosans

Upadhyaya

Singh²,

Agarwal

et al. 2013

Carbohydrate Polymers

299

130

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Synthesis, characterization and in vitro drug release of magnetic N-benzyl-O-carboxymethylchitosan nanoparticles loaded with indomethacin

Cited by 40 publications

References 31 publications

Development of iron modified MCM-41 as promising nano-composites with specific magnetic behavior

Development of iron modified MCM-41 as promising nano-composites with specific magnetic behavior

Functional group‐assisted green synthesised superparamagnetic nanoparticles for the rapid removal of hexavalent chromium from aqueous solution

Biomedical applications of carboxymethyl chitosans

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