Synthesis, characterization and in vitro antimicrobial screening studies of some pyridyl-coumarin compounds

Baluja, Shipra; Chanda, Sumitra; Padalia, Hemali; Talaviya, Rahul

doi:10.15446/rcciquifa.v46n1.67287

Cited by 1 publication

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References 17 publications

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“…The chemical shifts are expressed in δ values (ppm). The obtained data were preliminarily analysed for functional groups (Silva Sa et al 2017;Baluja et al 2017).…”

Section: Structure Characterizationsmentioning

confidence: 99%

Microbial diversity of a Himalayan forest and characterization of rare actinomycetes for antimicrobial compounds

et al. 2019

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The slow pace of discovery of new effective drugs against multi-drug resistant pathogens and largely unsuccessful combinatorial chemistry has resulted in shifting the focus back to natural products as sources of lead molecules for antimicrobial drugs, mainly due to their structural diversity. Investigation of under-explored habitats for potentially novel microorganisms provides for wider chemodiversity. In this study, four actinomycetes, namely UK-274, UK-281, UK-282 and UK-285, which showed broad-spectrum antibacterial and antifungal activities, were isolated from Timli forest range of the biodiversity-rich Himalayan region. 16S rRNA gene sequence analysis showed that the nearest neighbours of the isolates were Actinomadura nitrigenes, Streptomyces niveiscabiei, and Kitasatospora psammotica with similarity values ranging between 97 and 98% suggesting their potential as new isolates. Further morphological and phenotypic characterization strengthened this assumption. Isolate UK-282, of the rare actinomycetes Kitasatospora group, was found to produce antimicrobial activity. Metabolite fingerprinting of ethyl acetate fraction of isolate UK-282 by GC-MS and 1H NMR analysis showed the presence of three novel compounds. The study underlines that a combination approach of bioprospecting of under-studied habitats and focus on rare actinomycetes may result in the identification of novel chemodiversity.

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“…The chemical shifts are expressed in δ values (ppm). The obtained data were preliminarily analysed for functional groups (Silva Sa et al 2017;Baluja et al 2017).…”

Section: Structure Characterizationsmentioning

confidence: 99%