Synthesis, Characterization, and Investigation of Antimicrobial Properties of Salt and Metal Complexes of 2,6-Pyridinedicarboxylic Acid and 2-Amino-4,6-dimethylpyridine

Abstract

A new salt (3) of 2,6-pyridinedicarboxylic acid (1) and 2-amino-4,6-dimethylpyridine (2) and the metal complexes of the salt {(H2)x[M(1)2].nH2O, M = Fe (III), x = 1, n = 3 (4); M = Co(II), x = 2, n = 4 (5); M = Ni(II), x = 2, n = 5 (6); M = Cu(II), x = 2, n = 4 (7)} were synthesized. The structures of the compounds were suggested by AAS, IR, UV, magnetic susceptibility and molar conductivity methods. As a result of spectroscopic analysis, it was observed that all metal complexes had an ionic and octahedral structure. All substances were susceptible to Candida albicans (ATCC 14053) (yeast), Pseudomonas. aeruginosa (ATCC 27853), Staphylococcus aureus (NRRL-B 767), Listeria monocytogenes (ATCC 7644), Bacillus subtilis, Enterococcus faecalis (ATCC 29212), and Escherichia coli (ATCC 25922) bacteria were examined. Antimicrobial activity results were compared with Fluconazole, Ketoconazole, Chloramphenicol, Levofloxacin, Vancomycin and Cefepime. In the activity results, the best values were observed 3 in B. subtilis bacteria, 6 and 7 in S. aureus bacteria, 5 7 in P. aeruginoa bacteria, all compounds in L. monocytogenes bacteria, all compounds (except 4) in E. coli bacteria, 2 in E. faecalis bacteria and 4 in C. albicans yeast.