Synthesis, Characterization and Microbial Study Via Some New Salbutamol's Derivatives

Fenjan, Abdel-Amir M.; Dhahir, Saadiyah A.; Al-Sahib, Sanaa A.; Thanoon, Shatha

doi:10.22401/jnus.14.1.07

Cited by 1 publication

(1 citation statement)

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“…More than one reaction cycle was needed when the reactant had a low solubility in acetic anhydride as in the case of cholesterol, N -Boc-tyrosine methyl ester and salbutamol (entries 3, 8 and 9, Table 2). Comparing to data reported in the literature [42–43], the modest yields of peracetylated product obtained in case of cholesterol 3 and salbutamol 9 were balanced by the absence of catalyst and by the reaction speed due to microwaves. The applied P-program was compatible with the N -Boc protecting group already present on the tyrosine methyl ester 8 .…”

Section: Resultssupporting

confidence: 48%

Tunable microwave-assisted method for the solvent-free and catalyst-free peracetylation of natural products

Oliverio¹,

Costanzo²,

Nardi³

et al. 2016

Beilstein J. Org. Chem.

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Summary Background: The peracetylation is a simple chemical modification that can be used to enhance the bioavailability of hydrophilic products and to obtain safe and stable pro-drugs. Results: A totally green, solvent-free and catalyst-free microwave (MW)-assisted method for peracetylation of natural products such as oleuropein, alpha-hederin, quercetin and rutin is presented. By simply tuning the MW heating program, polyols with chemical diverse –OH groups or thermolabile functionalities can be peracetylated to improve the biological activity without degradation of the natural starting molecules. An evaluation of the process greenness was performed. Conclusion: The method is potentially universally applicable for green acetylation of hydrophilic biological molecules, potentially easily scalable for industrial applications, including pharmaceutical, cosmetic and food industry.

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Section: Resultssupporting

confidence: 48%