Synthesis, characterization and performance enhancement of dry polyaniline-coated neuroelectrodes for electroencephalography measurement

Aghazadeh, Hadiseh; Yazdi, Mohsen Khodadadi; Kolahi, Alireza; Yekani, Milad; Zarrintaj, Payam; Ramsey, Joshua D.; Ganjali, Mohammad Reza; Stadler, Florian J.; Saeb, Mohammad Reza; Mozafari, Masoud

doi:10.1016/j.cap.2021.04.003

Cited by 11 publications

(9 citation statements)

References 51 publications

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“…Tissue engineering, as a newly emerging field, has attracted significant attention for the regeneration of damaged tissues/organs. Different factors are centered on tissue engineering, including cells, biological factors, and scaffolds [1][2][3]. Scaffolds can be fabricated with different structures like hydrogels that provide a proper environment for cellular activities.…”

Section: Introductionmentioning

confidence: 99%

A Green Composite Based on Gelatin/Agarose/Zeolite as a Potential Scaffold for Tissue Engineering Applications

et al. 2021

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Designing a novel platform capable of providing a proper tissue regeneration environment is a key factor in tissue engineering. Herein, a green composite based on gelatin/agarose/zeolite with pomegranate peel extract was fabricated as an innovative platform for tissue engineering. Gelatin/agarose was loaded with pomegranate peel extract-loaded zeolite to evaluate its swelling behavior, porosity, release rate, and cell viability performance. The composite characteristics were evaluated using XRD and DSC. The hydrogel performance can be adjusted for the desired aim by zeolite content manipulation, such as controlled release. It was shown that the green nanocomposite exhibited proper cellular activity along with a controlled release rate. Moreover, the hydrogel composite’s swelling ratio was decreased by adding zeolite. This study suggested a fully natural composite as a potential biomaterial for tissue engineering, which opens new ways to design versatile hydrogels for the regeneration of damaged tissues. The hydrogel performance can be adjusted specifically by zeolite content manipulation for controlled release.

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Section: Introductionmentioning

confidence: 99%

A Green Composite Based on Gelatin/Agarose/Zeolite as a Potential Scaffold for Tissue Engineering Applications

et al. 2021

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“…43 Moreover, unlike metal electrodes, conductive polymers are also capable of preventing skin injuries. 34 CPs are being extensively studied as a method to mitigate limitations aforementioned in miniaturization due to their beneficial characteristics such as biocompatibility, environmental biostability, and chronic functionality. 30 The widely used CPs in neuroelectrode design are the polydimethylsiloxane (PDMS), polypyrrole (PPy), poly(3,4-ethylenedioxythiophene) (PEDOT), and polyaniline (PANI).…”

Section: Polymeric Biomaterials In Neuroprostheticsmentioning

confidence: 99%

“…PANI has been greatly investigated for its application in neuroprostheses development due to its good electrical conductivity behavior. In a recent study conducted by Aghazadeh et al, 34 PANI coated stainless steel dry electrode was manufactured using electropolymerization method. Using a skin model, the contact impedance of the PANI-coated electrodes was recorded, which apparently showed great reduction compared to that of bare electrodes.…”

Section: Polymeric Biomaterials In Neuroprostheticsmentioning

confidence: 99%

“…46 Currently, polymer based electrodes are in high demand because of their tissue like mechanical properties, relatively easy production process and low budget. 34 Hence, hybrid materials such as metal-polymer hybrid electrodes come into play solving the drawback considering the difference in modulus between metals and soft tissues. 2 On the other hand, miniaturization of electrodes is of great contemporary relevance due to its ability to improve single neuron recording.…”

Section: Polymeric Biomaterials In Neuroprostheticsmentioning

confidence: 99%

“…43 Moreover, unlike metal electrodes, conductive polymers are also capable of preventing skin injuries. 34 CPs are being extensively studied as a method to mitigate limitations aforementioned in miniaturization due to their beneficial characteristics such as biocompatibility, environmental 17 Cassar et al, 18 Dalrymple et al 19 Aurum Biocompatibility, good conductivity Kim et al 20 Iridium oxide Good biostability, high charge storage capacity Hasenkamp et al 21…”

Section: Conductive Polymersmentioning

confidence: 99%

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Exploring polymeric biomaterials in developing neural prostheses

Silvaragi

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et al. 2022

Journal of Bioactive and Compatible Polymers

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Neuroprosthetics, with a range of applications such as cognitive, auditory, pain relief, recording, motor, and visual prosthetics have emerged as a promising field in recent years. However, poor electrical conductivity, a high disparity between tissue and interfaces and the onset of reactive gliosis post-implantation remains major challenges in the development of neuroprostheses. The choice of biomaterials in designing the neural interfaces’ in neuroprosthetic applications is of high importance, as the overall sustained performance of neuroprosthetic devices is based on the features of materials used for the neural interfaces. Numerous biomaterials, such as metals and carbon-based materials, have been used in neuroprosthetics thus far. Nonetheless, neuroprosthetics made from polymeric biomaterials are in high demand due to their high biocompatibility, conductivity, and biostability. Furthermore, polymeric biomaterials can be used as a hybrid design to overcome the limitations of other co-biomaterials. This article makes an attempt to review the polymeric biomaterials involved in this cutting-edge technology utilized for different purposes such as substrates, coatings, and miniaturization of electrodes, that might help in enriching our understanding on neuroprosthetics.

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Human Organs‐on‐Chips: A Review of the State‐of‐the‐Art, Current Prospects, and Future Challenges

et al. 2021

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New emerging technologies, remarkably miniaturized 3D organ models and microfluidics, enable simulation of the real in vitro microenvironment ex vivo more closely. There are many fascinating features of innovative organ‐on‐a‐chip (OOC) technology, including the possibility of integrating semipermeable and/or stretchable membranes, creating continuous perfusion of fluids into microchannels and chambers (while maintaining laminar flow regime), embedding microdevices like microsensors, microstimulators, micro heaters, or different cell lines, along with other 3D cell culture technologies. OOC systems are designed to imitate the structure and function of human organs, ranging from breathing lungs to beating hearts. This technology is expected to be able to revolutionize cell biology studies, personalized precision medicine, drug development process, and cancer diagnosis/treatment. OOC systems can significantly reduce the cost associated with tedious drug development processes and the risk of adverse drug reactions in the body, which makes drug screening more effective. The review mainly focus on presenting an overview of the several previously developed OOC systems accompanied by subjects relevant to pharmacy‐, cancer‐, and placenta‐on‐a‐chip. The challenging issues and opportunities related to these systems are discussed, along with a future perspective for this technology.

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Synthesis, characterization and performance enhancement of dry polyaniline-coated neuroelectrodes for electroencephalography measurement

Cited by 11 publications

References 51 publications

A Green Composite Based on Gelatin/Agarose/Zeolite as a Potential Scaffold for Tissue Engineering Applications

A Green Composite Based on Gelatin/Agarose/Zeolite as a Potential Scaffold for Tissue Engineering Applications

Exploring polymeric biomaterials in developing neural prostheses

Human Organs‐on‐Chips: A Review of the State‐of‐the‐Art, Current Prospects, and Future Challenges

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